Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
95 results
Cited 43 times since 2011 (3.3 per year) source: EuropePMC
Basic research in cardiology, Volume 106, Issue 5, 24 4 2011, Pages 829-847 In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1. Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC, Goumans MJ
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac repair. To understand what drives epicardial EMT, we used an in vitro model for human adult epicardial cells. These cells have an epithelium-like... Abstract
Cited 13 times since 2011 (1 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 142, Issue 3, 12 2 2011, Pages e93-100 Cardiac support device, restrictive mitral valve annuloplasty, and optimized medical treatment: a multimodality approach to nonischemic cardiomyopathy. Braun J, Ciarka A, Versteegh MI, Delgado V, Boersma E, Verwey HF, Schalij MJ, Bax JJ, Dion RA, van de Veire NR, Klautz RJ
Objective: Nonischemic dilated cardiomyopathy with functional mitral regurgitation carries a poor prognosis. Mitral valve surgery with implantation of a cardiac support device can treat mitral regurgitation and promote left ventricular reverse remodeling. This observational study evaluates clinical and echocardiographic outcomes of an individualized medico-surgical approach, focusing on mitral regurgitation recurrence and left ventricular reverse remodeling. Methods: Sixty-nine consecutive patie... Abstract
Cited 19 times since 2011 (1.4 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 91, Issue 2, 1 1 2011, Pages 491-498 Surgical ventricular restoration for patients with ischemic heart failure: determinants of two-year survival. Witkowski TG, ten Brinke EA, Delgado V, Ng AC, Bertini M, Marsan NA, Ewe SH, Auger D, Yiu KH, Braun J, Klein P, Steendijk P, Versteegh MI, Klautz RJ, Bax JJ
Background: Surgical ventricular restoration (SVR) improves left ventricular (LV) systolic function by partially restoring the normal geometry of the left ventricle. However, the beneficial effects of this surgical procedure on long-term clinical outcome remain controversial. The present study aimed to evaluate the independent determinants of 2-year morbidity and mortality rates after SVR. Methods: Seventy-nine patients with ischemic heart disease and LV ejection fraction of 0.35 or less were in... Abstract
Cited 16 times since 2010 (1.2 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 90, Issue 6, 1 1 2010, Pages 1913-1920 Clinical and functional effects of restrictive mitral annuloplasty at midterm follow-up in heart failure patients. ten Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Delgado V, Holman ER, Schalij MJ, van der Wall EE, Braun J, Versteegh MI, Dion RA, Steendijk P
Background: Restrictive mitral annuloplasty (RMA) is increasingly applied to treat functional mitral regurgitation in heart failure patients. Previous studies indicated beneficial clinical effects with low recurrence rates. However, the underlying pathophysiology is complex and outcome in terms of left ventricular function is not well known. We investigated chronic effects of RMA on ventricular function in relation to clinical outcome. Methods: Heart failure patients (n = 11) with severe mitral... Abstract
Cited 221 times since 2010 (16.4 per year) source: EuropePMC
JAMA, Volume 304, Issue 20, 1 1 2010, Pages 2245-2252 Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. Annema JT, van Meerbeeck JP, Rintoul RC, Dooms C, Deschepper E, Dekkers OM, De Leyn P, Braun J, Carroll NR, Praet M, de Ryck F, Vansteenkiste J, Vermassen F, Versteegh MI, Veseliç M, Nicholson AG, Rabe KF, Tournoy KG
Context: Mediastinal nodal staging is recommended for patients with resectable non-small cell lung cancer (NSCLC). Surgical staging has limitations, which results in the performance of unnecessary thoracotomies. Current guidelines acknowledge minimally invasive endosonography followed by surgical staging (if no nodal metastases are found by endosonography) as an alternative to immediate surgical staging. Objective: To compare the 2 recommended lung cancer staging strategies. Design, setting, and... Abstract
Cited 88 times since 2010 (6.5 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 141, Issue 6, 15 3 2010, Pages 1431-1439 Tricuspid annuloplasty prevents right ventricular dilatation and progression of tricuspid regurgitation in patients with tricuspid annular dilatation undergoing mitral valve repair. Van de Veire NR, Braun J, Delgado V, Versteegh MI, Dion RA, Klautz RJ, Bax JJ
Objectives: We hypothesize that concomitant tricuspid annuloplasty in patients with tricuspid annular dilatation who undergo mitral valve repair could prevent progression of tricuspid regurgitation and right ventricular remodeling. Methods: In 2002, 80 patients underwent mitral valve repair. Concomitant tricuspid annuloplasty was performed in 13 patients with grade 3 or 4 tricuspid regurgitation. In 2004, 102 patients underwent mitral valve repair. Concomitant tricuspid annuloplasty was performe... Abstract
Cited 89 times since 2010 (6.5 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 3, 1 1 2010, Pages 395-401 Predictors of mitral regurgitation recurrence in patients with heart failure undergoing mitral valve annuloplasty. Ciarka A, Braun J, Delgado V, Versteegh M, Boersma E, Klautz R, Dion R, Bax JJ, Van de Veire N
Restrictive mitral annuloplasty is a surgical treatment option for patients with heart failure (HF) and functional mitral regurgitation (MR). However, recurrent MR has been reported at mid-term follow-up. The aim of the present study was to identify the echocardiographic predictors of recurrent MR in patients with HF undergoing mitral annuloplasty. During a mean follow-up of 2.6 +/- 1.6 years, 109 patients with HF (49% ischemic and 51% idiopathic dilated cardiomyopathy) who had undergone mitral... Abstract
The Annals of thoracic surgery, Volume 89, Issue 5, 1 1 2010, Pages 1554 Invited commentary. Braun J
The Annals of thoracic surgery, Volume 89, Issue 4, 1 1 2010, Pages 1161-1162 Invited commentary. Braun J
The Annals of thoracic surgery, Volume 88, Issue 5, 1 1 2009, Pages 1504-1505 Invited commentary. Braun J
Cited 9 times since 2009 (0.6 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 69, Issue 1, 15 3 2009, Pages 60-65 EUS-FNA in the preoperative staging of non-small cell lung cancer. Talebian M, von Bartheld MB, Braun J, Versteegh MI, Dekkers OM, Rabe KF, Annema JT
Background: According to current guidelines, transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) can be performed as an alternative for surgical staging to confirm mediastinal metastases in patients with non-small cell lung cancer (NSCLC). To date however, data regarding the routine use of EUS-FNA in the preoperative staging of unselected patients with NSCLC are limited. Aims and objectives: (1) To evaluate the diagnostic value of EUS-FNA in consecutive, patients with NSCLC regard... Abstract
The Annals of thoracic surgery, Volume 87, Issue 1, 1 1 2009, Pages 155-156 Invited commentary. Braun J
Interactive cardiovascular and thoracic surgery, Volume 7, Issue 5, 1 1 2008, Pages 886 eComment: also in cardiac arrest it is important to think first. Versteegh MI, Braun J
Cited 10 times since 2008 (0.6 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 135, Issue 6, 1 1 2008, Pages 1247-52; discussion 1252-3 Magnetic resonance imaging assessment of reverse left ventricular remodeling late after restrictive mitral annuloplasty in early stages of dilated cardiomyopathy. Westenberg JJ, Braun J, Van de Veire NR, Klautz RJ, Versteegh MI, Roes SD, van der Geest RJ, de Roos A, van der Wall EE, Reiber JH, Bax JJ, Dion RA
Objective: Magnetic resonance imaging was used to evaluate left ventricular reverse remodeling at long-term follow-up (3-4 years) after restrictive mitral annuloplasty in patients with early stages of nonischemic, dilated cardiomyopathy, and severe mitral regurgitation. Methods: Twenty-two selected patients (eligible to undergo magnetic resonance imaging) with mild to moderate heart failure (mean New York Heart Association class 2.2 +/- 0.4), dilated cardiomyopathy (left ventricular ejection fra... Abstract
Cited 146 times since 2008 (9 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 85, Issue 2, 1 1 2008, Pages 430-6; discussion 436-7 Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure. Braun J, van de Veire NR, Klautz RJ, Versteegh MI, Holman ER, Westenberg JJ, Boersma E, van der Wall EE, Bax JJ, Dion RA
Background: Restrictive mitral annuloplasty with revascularization is considered the best approach to ischemic mitral regurgitation with heart failure, but late results are controversial. We report late outcome in relation to preoperative left ventricular end-diastolic diameter (LVEDD) cutoff values, previously identified to predict intermediate-term left ventricular reverse remodeling. Methods: One hundred consecutive ischemic mitral regurgitation patients underwent restrictive mitral annulopla... Abstract
Cited 47 times since 2007 (2.8 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 32, Issue 3, 19 3 2007, Pages 449-456 Diaphragm plication in adult patients with diaphragm paralysis leads to long-term improvement of pulmonary function and level of dyspnea. Versteegh MI, Braun J, Voigt PG, Bosman DB, Stolk J, Rabe KF, Dion RA
Objective: There is still controversy about the feasibility and long-term outcome of surgical treatment of acquired diaphragm paralysis. We analyzed the long-term effects on pulmonary function and level of dyspnea after unilateral or bilateral diaphragm plication. Methods: Between December 1996 and January 2006, 22 consecutive patients underwent diaphragm plication. Before surgery, spirometry in both seated and supine positions and a Baseline Dyspnea Index were assessed. The uncut diaphragm was... Abstract
The Annals of thoracic surgery, Volume 82, Issue 6, 1 1 2006, Pages 2110 Invited commentary. Braun J
Cited 10 times since 2006 (0.6 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 23, Issue 2, 29 5 2006, Pages 159-165 Plasma natriuretic peptide levels reflect changes in heart failure symptoms, left ventricular size and function after surgical mitral valve repair. Feringa HH, Poldermans D, Klein P, Braun J, Klautz RJ, van Domburg RT, van der Laarse A, van der Wall EE, Dion RA, Bax JJ
Background and aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has diagnostic and prognostic value in patients with heart failure. The present prospective study was designed to assess whether changes in NT-proBNP levels after surgical mitral valve repair reflect changes in heart failure symptoms and changes in left atrial size, left ventricular size and left ventricular function. Methods: The study population consisted of 22 patients (mean age: 62.8 +/- 14.2 years, 68% male) undergoin... Abstract
Cited 8 times since 2006 (0.4 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 29, Issue 3, 19 3 2006, Pages 367-373 Outcome after mitral valve repair for acute and healed infective endocarditis. Feringa HH, Bax JJ, Klein P, Klautz RJ, Braun J, van der Wall EE, Poldermans D, Dion RA
Objective: To evaluate the long-term clinical and echocardiographic outcomes after mitral valve surgery for acute and healed infective endocarditis. Methods: Of 37 consecutive patients presenting with native mitral valve endocarditis, mitral valve repair (MVRep) was feasible in 34 (92%) patients. In 17 (50%) patients, surgery was indicated during antibiotic therapy (acute endocarditis), whereas 17 (50%) underwent surgery after antibiotic therapy was completed (healed endocarditis). Patients were... Abstract
The Annals of thoracic surgery, Volume 80, Issue 6, 1 1 2005, Pages 2255-2256 Invited commentary. Braun J