Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7490 results
Cited 12 times since 2011 (1 per year) source: EuropePMC
Nucleic acids research, Volume 40, Issue 8, 20 3 2011, Pages 3443-3455 Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA
The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s... Abstract
Cited 17 times since 2011 (1.4 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 23, Issue 7, 19 3 2011, Pages 1723-1729 Biomarker analysis in a phase III study of pemetrexed-carboplatin versus etoposide-carboplatin in chemonaive patients with extensive-stage small-cell lung cancer. Smit EF, Socinski MA, Mullaney BP, Myrand SP, Scagliotti GV, Lorigan P, Reck M, Ciuleanu T, von Pawel J, Karaseva NA, Szczesna A, Ohannesian D, Powell E, Hozak RR, Hong S, Guba SC, Thatcher N
Background: Clinical results of a randomized phase III trial comparing pemetrexed-carboplatin (PC) with etoposide-carboplatin (EC) in chemonaive patients with extensive-stage disease small-cell lung cancer (ED-SCLC) resulted in trial closure for futility; biomarker analyses using immunohistochemistry (IHC) and single-nucleotide polymorphisms (SNPs) are described herein. Patients and methods: Thymidylate synthase (TS), excision repair cross complementing-1 (ERCC1), glycinamide ribonucleotide form... Abstract
Cited 7 times since 2011 (0.6 per year) source: EuropePMC
The Journal of rheumatology, Volume 39, Issue 1, 15 3 2011, Pages 100-105 Pulmonary arterial hypertension in systemic sclerosis is associated with profound impairment of microvascular endothelium-dependent vasodilatation. Hofstee HM, Voskuyl AE, Vonk Noordegraaf A, Smulders YM, Postmus PE, Dijkmans BA, Serné EH
Objective: Impaired microvascular function may contribute to organ complications in patients with systemic sclerosis (SSc). We investigated whether SSc patients with and without pulmonary arterial hypertension (PAH) show a graded impairment of microvascular function compared to healthy controls. Methods: Twenty-two patients with SSc and 22 controls were studied. All patients underwent right heart catheterization; 6 had no PAH (SSc-nonPAH) and 16 had PAH (SSc-PAH). Acetylcholine (ACh)-mediated en... Abstract
Cited 110 times since 2011 (8.9 per year) source: EuropePMC
Circulation. Heart failure, Volume 5, Issue 1, 9 2 2011, Pages 97-105 Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. de Man FS, Handoko ML, van Ballegoij JJ, Schalij I, Bogaards SJ, Postmus PE, van der Velden J, Westerhof N, Paulus WJ, Vonk-Noordegraaf A
Background: In pulmonary arterial hypertension (PH), sympathetic adrenergic activity is highly elevated. Sympathetic overactivity is a compensatory mechanism at first, but might be detrimental for cardiac function in the long run. We therefore investigated whether chronic low-dose treatment with bisoprolol (a cardioselective β-blocker) has beneficial effects on cardiac function in experimental PH. Methods and results: PH was induced in rats by a single injection of monocrotaline (60 mg/kg). Pres... Abstract
Cited 45 times since 2011 (3.6 per year) source: EuropePMC
Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP
Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract
Cited 20 times since 2011 (1.6 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 46, Issue 5, 8 2 2011, Pages 607-613 α1-antitrypsin production by proinflammatory and antiinflammatory macrophages and dendritic cells. van 't Wout EF, van Schadewijk A, Savage ND, Stolk J, Hiemstra PS
α(1)-Antitrypsin (AAT) acts as an important neutrophil elastase inhibitor in the lung. Although the hepatocyte is considered to be the primary source of AAT, local production by monocytes, macrophages, and epithelial cells may contribute to the formation of an antielastase screen. Because monocytes can differentiate into a heterogeneous population of macrophages with subpopulations ranging from proinflammatory properties (MΦ-1) to antiinflammatory properties (ΜΦ-2) and into dendritic cells (DCs)... Abstract
Cited 21 times since 2011 (1.7 per year) source: EuropePMC
Atherosclerosis, Volume 220, Issue 2, 7 1 2011, Pages 456-462 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ
Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376... Abstract
Cited 17 times since 2011 (1.4 per year) source: EuropePMC
PloS one, Volume 6, Issue 12, 6 1 2011, Pages e28638 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ
Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in... Abstract
Cited 15 times since 2011 (1.2 per year) source: EuropePMC
Respiratory medicine, Volume 106, Issue 5, 5 1 2011, Pages 677-686 Influence of inspiration level on bronchial lumen measurements with computed tomography. Bakker ME, Stolk J, Reiber JH, Stoel BC
Background: Bronchial dimensions measured in CT images generally do not take inspiration level into consideration. However, some studies showed that the bronchial membrane is distensible with airway inflation. Therefore, re-examination of the elasticity of bronchi is needed. Purpose: To assess the influence of respiration on bronchial lumen area (defined as distensibility) in different segmental bronchi and to explore the correlations between distensibility and both lung function and emphysema s... Abstract
Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 559-564 Prognostic significance of baseline ST-T-wave abnormalities in diagnostic stress echocardiography. Pedone C, Elhendy A, van Domburg RT, Nelwan SP, Biagini E, Di Pasquale G, Bax JJ, Poldermans D
Objective: The aim of this study was to determine whether resting ST-T wave abnormalities (ST-Ta) provide incremental prognostic information in patients with no history of coronary artery disease undergoing dobutamine stress echocardiography (DSE). Methods: We evaluated 1308 consecutive patients without previous myocardial infarction (MI) or revascularization who underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities. End points during follow-up were all-cause death an... Abstract
Cited 11 times since 2011 (0.9 per year) source: EuropePMC
Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 533-536 Distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, Yiu KH, Atary JZ, Delgado V, Holman ER, van der Wall EE, Schuijf JD, Bax JJ, Schalij MJ
Objectives: Data regarding the distribution of vulnerable lesions in the coronary arteries are scarce. The aim was to evaluate the frequency and distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction. In addition, the location of culprit lesions was related to infarct size. Methods: Consecutive patients (N=1533, mean age 61±12 years) were evaluated. All patients were treated with primary percutaneous coronary intervention and underwent two-dimensional e... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
World journal of surgery, Volume 35, Issue 12, 1 1 2011, Pages 2829-30; author reply 2831 Re: Risk factors for stroke during surgery for carotid body tumors. van der Bogt KE, van Baalen JM, Hamming JF
Cited 6 times since 2011 (0.5 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 12, 1 1 2011, Pages 509-513 Advanced therapy for pulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ
Cited 9 times since 2011 (0.7 per year) source: EuropePMC
The New England journal of medicine, Volume 365, Issue 25, 1 1 2011, Pages 2434-5; author reply 2435-6 Genetics of glucocorticoids in asthma. van den Berge M, Hiemstra PS, Postma DS
Cited 85 times since 2011 (6.8 per year) source: EuropePMC
British journal of cancer, Volume 105, Issue 12, 1 1 2011, Pages 1912-1919 Renal cancer and pneumothorax risk in Birt-Hogg-Dubé syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families. Houweling AC, Gijezen LM, Jonker MA, van Doorn MB, Oldenburg RA, van Spaendonck-Zwarts KY, Leter EM, van Os TA, van Grieken NC, Jaspars EH, de Jong MM, Bongers EM, Johannesma PC, Postmus PE, van Moorselaar RJ, van Waesberghe JH, Starink TM, van Steensel MA, Gille JJ, Menko FH
Background: Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was to assess the risk of renal cancer, the histological subtypes of renal tumours and the pneumothorax risk in BHD. Methods: In this study we present the clinical data of 115 FLCN mut... Abstract
Cited 60 times since 2011 (4.8 per year) source: EuropePMC
Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ
Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract
Cited 21 times since 2011 (1.7 per year) source: EuropePMC
Journal of cellular and molecular medicine, Volume 15, Issue 12, 1 1 2011, Pages 2675-2683 Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC
The myocardium of the developing heart tube is covered by epicardium. These epicardial cells undergo a process of epithelial-to-mesenchymal transformation (EMT) and develop into epicardium-derived cells (EPDCs). The ingrowing EPDCs differentiate into several celltypes of which the cardiac fibroblasts form the main group. Disturbance of EMT of the epicardium leads to serious hypoplasia of the myocardium, abnormal coronary artery differentiation and Purkinje fibre paucity. Interestingly, the elect... Abstract
Cited 77 times since 2011 (6.2 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2011, Pages 51-59 Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, van der Geest RJ, Bonetti C, van der Velde ET, de Roos A, Smit JW, Leung DY, Bax JJ, Lamb HJ
Background: Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T(1) mapping is a previously validated imaging technique that can quantify the burden of global and regional interstitial fibrosis. However, the association between MRI T(1) mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown. Methods and results: Fifty diabetic patients with normal LV ejection fraction (EF) and no underlying... Abstract
Cited 7 times since 2011 (0.6 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 421-429 Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study. van der Veen BJ, Al Younis I, Ajmone-Marsan N, Westenberg JJ, Bax JJ, Stokkel MP, de Roos A
Purpose: Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony. Methods: For the normal population 80 patients (40 men... Abstract
Cited 6 times since 2011 (0.5 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 416-420 Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M
Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascula... Abstract