Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
94 results
Cited 45 times since 2010 (3.3 per year) source: EuropePMC
International journal of cardiology, Volume 154, Issue 2, 8 2 2010, Pages 168-172 Circumstances of death in adult congenital heart disease. Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, van den Merkhof LF, Baur LH, Ansink TJ, Cozijnsen L, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ
Background: Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD). Methods: Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD. Results: Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart failure... Abstract
Cited 20 times since 2010 (1.5 per year) source: EuropePMC
International journal of cardiology, Volume 152, Issue 2, 1 1 2010, Pages 212-217 Mortality in adult congenital heart disease: are national registries reliable for cause of death? Zomer AC, Uiterwaal CS, van der Velde ET, Tijssen JG, Mariman EC, Verheugt CL, Vaartjes I, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ
Background: Statistics on cause-specific mortality are important for prognostic research. The aim of this study was to assess the utility of the national mortality registry in research on causes of death in adult patients with congenital heart disease (CHD). Methods: The CONCOR registry of over 10,000 adults with CHD was used to verify the causes of death provided by the WHO guidelines based national mortality registry, by linkage. Results: Of 7277 patients linked to the national mortality regis... Abstract
Cited 79 times since 2010 (5.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 11, 20 3 2010, Pages 872-878 The emerging burden of hospital admissions of adults with congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ
Objective: To assess the extent and the characteristics of hospital admissions in registered adult patients with congenital heart disease. Design: Observational cohort study. Setting: The Netherlands. Patients: 5798 adult patients with congenital heart disease from the Dutch CONCOR national registry linked to the Dutch National Medical Registration (Prismant). Main outcome measures: All hospital admissions from the years 2001 up until 2006. Results: During 28 990 patient-years, 2908 patients (50... Abstract
Cited 19 times since 2010 (1.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 8, 1 1 2010, Pages 621-624 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. van Engelen K, Topf A, Keavney BD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ
Background: Three quarters of patients with 22q11.2 Deletion Syndrome (22q11.2DS) have congenital heart disease (CHD), typically conotruncal heart defects. Although it is currently common practice to test all children with typical CHD for 22q11.2DS, many adult patients have not been tested in the past and therefore 22q11.2DS might be under-recognised in adults. Objectives: To determine the prevalence of 22q11.2DS in adults with tetralogy of Fallot (TOF) and pulmonary atresia (PA)/ventricular sep... Abstract
Cited 257 times since 2010 (18.2 per year) source: EuropePMC
European heart journal, Volume 31, Issue 10, 5 1 2010, Pages 1220-1229 Mortality in adult congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, van Dijk AP, Vliegen HW, Grobbee DE, Mulder BJ
Aims: Mortality in adults with congenital heart disease is known to be increased, yet its extent and the major mortality risks are unclear. Methods and results: The Dutch CONCOR national registry for adult congenital heart disease was linked to the national mortality registry. Cox's regression was used to assess mortality predictors. Of 6933 patients, 197 (2.8%) died during a follow-up of 24 865 patient-years. Compared with the general national population, there was excess mortality, partic... Abstract
Cited 6 times since 2010 (0.4 per year) source: EuropePMC
Circulation, Volume 121, Issue 12, 1 1 2010, Pages e252; author reply e253 Letter by Winter et al regarding article, "Children and adults with congenital heart disease lost to follow-up: who and when?". Winter MM, Mulder BJ, van der Velde ET
Cited 36 times since 2010 (2.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 55, Issue 9, 1 1 2010, Pages 879-885 Prognostic importance of atrial fibrillation in implantable cardioverter-defibrillator patients. Borleffs CJ, van Rees JB, van Welsenes GH, van der Velde ET, van Erven L, Bax JJ, Schalij MJ
Objectives: This study aimed to assess the prevalence of different types of atrial fibrillation (AF) and their prognostic importance in implantable cardioverter-defibrillator (ICD) patients. Background: The prevalence of AF has taken epidemic proportions in the population with cardiovascular disease. The prognostic importance of different types of AF in ICD patients remains unclear. Methods: Data on 913 consecutive patients (79% men, mean age 62 + or - 13 years) receiving an ICD at the Leiden Un... Abstract
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 33, Issue 4, 1 1 2009, Pages 431-436 Implementation of lead safety recommendations. VAN Rees JB, Borleffs CJ, Bax JJ, Nagtegaal EM, VAN DER Velde ET, VAN Erven L, Schalij MJ
Background: The Medtronic Sprint Fidelis (SF) implantable cardioverter defibrillator (ICD; Medtronic Inc., Minneapolis, MN, USA) lead has a higher than expected failure rate. Because of patient safety, Medtronic announced two advisories consisting of (1) adjustments in device settings (October 2007) and (2) installation of a lead integrity algorithm (May 2008). The objective of this study was to evaluate the effect of Medtronic's announcements on patient safety. Methods: To comply with the... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 6, 23 4 2009, Pages 712-718 Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease. Borleffs CJ, van Welsenes GH, van Bommel RJ, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Rosendaal FR, Schalij MJ
Aims: To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease. Methods and results: Since 1996, data of all consecutive patients who received an ICD system in the Leiden University Medical Center were collected and assessed at implantation. For the current study, all 1036 patients [age 63 (SD 11) years, 81% male] with a primary indication for defibrillator implant... Abstract
Cited 50 times since 2009 (3.3 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 4, 17 3 2009, Pages 411-416 Risk of failure of transvenous implantable cardioverter-defibrillator leads. Borleffs CJ, van Erven L, van Bommel RJ, van der Velde ET, van der Wall EE, Bax JJ, Rosendaal FR, Schalij MJ
Background: Despite the positive effect on mortality in selected patients, implantable cardioverter-defibrillator therapy is also associated with potential malfunction of the implanted system. The present study provides the long-term lead failure rate in a large single-center cohort. Methods and results: Since 1992, a total of 2068 implantable cardioverter-defibrillator patients with 2161 defibrillation leads were prospectively collected. Data of the implant procedure and all follow-up visits we... Abstract
Cited 62 times since 2008 (3.9 per year) source: EuropePMC
Circulation, Volume 118, Issue 1, 16 3 2008, Pages 26-32 Gender and outcome in adult congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Vliegen HW, van Dijk AP, Bouma BJ, Grobbee DE, Mulder BJ
Background: Gender differences in prognosis have frequently been reported in cardiovascular disease but less so in congenital heart disease. We investigated whether gender is associated with outcome in adult patients with congenital heart disease. Methods and results: From the CONgenital CORvitia (CONCOR) national registry for adults with congenital heart disease, 7414 patients were identified. All outcomes before entry into the registry and during subsequent follow-up were recorded, and differe... Abstract
Cited 69 times since 2007 (4 per year) source: EuropePMC
American heart journal, Volume 153, Issue 1, 1 1 2007, Pages 14.e1-11 MISSION!: optimization of acute and chronic care for patients with acute myocardial infarction. Liem SS, van der Hoeven BL, Oemrawsingh PV, Bax JJ, van der Bom JG, Bosch J, Viergever EP, van Rees C, Padmos I, Sedney MI, van Exel HJ, Verwey HF, Atsma DE, van der Velde ET, Jukema JW, van der Wall EE, Schalij MJ
Background: Guideline implementation programs for patients with acute myocardial infarction (AMI) enhance adherence to evidence-based medicine (EBM) and improve clinical outcome. Although undertreatment of patients with AMI is well recognized in both acute and chronic phases of care, most implementation programs focus on acute and secondary prevention strategies during the index hospitalization phase only. Hypothesis: Implementation of an all-phase integrated AMI care program maximizes EBM in da... Abstract
Cited 138 times since 2006 (8 per year) source: EuropePMC
International journal of cardiology, Volume 120, Issue 2, 19 3 2006, Pages 198-204 Pulmonary arterial hypertension in congenital heart disease: an epidemiologic perspective from a Dutch registry. Duffels MG, Engelfriet PM, Berger RM, van Loon RL, Hoendermis E, Vriend JW, van der Velde ET, Bresser P, Mulder BJ
Background: Pulmonary arterial hypertension (PAH) associated with congenital heart disease is usually the result of a large systemic-to-pulmonary shunt, and often leads to right ventricular failure and early death. The purpose of this study was to determine the prevalence of PAH among adult patients included in a national registry of congenital heart disease and to assess the relation between patient characteristics and PAH. Methods: Patients with PAH associated with a septal defect were identif... Abstract
Cited 152 times since 2005 (7.9 per year) source: EuropePMC
European journal of epidemiology, Volume 20, Issue 6, 1 1 2005, Pages 549-557 CONCOR, an initiative towards a national registry and DNA-bank of patients with congenital heart disease in the Netherlands: rationale, design, and first results. van der Velde ET, Vriend JW, Mannens MM, Uiterwaal CS, Brand R, Mulder BJ
Introduction: Survival of patients with congenital heart disease has dramatically improved after surgical repair became available 40 years ago. Instead of a mortality of 85% during childhood following the natural course, over 85% of these infants are now expected to reach adulthood. However, data on long-term outcome is scarce due to the lack of large, national registries. Moreover, little is known about the genetic basis of congenital heart defects. In 2000, the Interuniversity Cardiology Insti... Abstract
Cited 12 times since 2004 (0.6 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 148, Issue 33, 1 1 2004, Pages 1646-1647 [National registry and DNA-bank of patients with congenital heart disease: the CONCOR-project]. Vriend JW, van der Velde ET, Mulder BJ
Although survival of patients with congenital heart disease has dramatically improved since surgical repair has become available, cure is seldom achieved. Exact data on long-term outcome are not available, however, because a national registry is lacking. Furthermore, little is known about the role of genetic defects in the development of congenital heart disease. The CONCOR-project (CONgenital CORvitia) has been set up to facilitate the investigation of the long-term outcome and molecular basis... Abstract
Cited 57 times since 2003 (2.8 per year) source: EuropePMC
Circulation, Volume 108, Issue 17, 29 5 2003, Pages 2099-2106 Voltage and activation mapping: how the recording technique affects the outcome of catheter ablation procedures in patients with congenital heart disease. de Groot NM, Schalij MJ, Zeppenfeld K, Blom NA, Van der Velde ET, Van der Wall EE
Background: Endocardial mapping is mandatory before radiofrequency catheter ablation (RFCA). Mapping can be performed with either unipolar or bipolar recordings. Impact of the recording technique used was studied in patients with and without structural heart disease using the 3D electroanatomic CARTO mapping system. Methods and results: Patients (n=44; 16 males; age 43+/-16 years) referred for RFCA of atrial flutter (AFL, n=18), focal atrial tachycardia (FAT, n=4), AV nodal reentrant tachycardia... Abstract
Cited 7 times since 2003 (0.3 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 24, Issue 1, 1 1 2003, Pages 98-104 Reproducible model of post-infarction left ventricular dysfunction: haemodynamic characterization by conductance catheter. Hasnat AK, van der Velde ET, Hon JK, Yacoub MH
Objective: The understanding of pathophysiology and cellular mechanisms of chronic heart failure requires the creation of appropriate and accurately characterized animal models, thus enabling meaningful evaluation of evolving medical and surgical therapies. Methods: The left anterior descending and its diagonal branch were ligated in 12 sheep to induce left ventricular dysfunction. Results: Study of left ventricular pressure-volume loops 3 months post-operatively showed a significant deteriorati... Abstract
Cited 1 times since 2002 (0 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 9, 1 1 2002, Pages 345-348 Adults with congenital heart disease: a growing population. Vriend JW, van der Velde ET, Mulder BJ
Cited 5 times since 2001 (0.2 per year) source: EuropePMC
Cardiovascular research, Volume 51, Issue 4, 1 1 2001, Pages 729-735 The volume-dependency of parallel conductance throughout the cardiac cycle and its consequence for volume estimation of the left ventricle in patients. Kornet L, Schreuder JJ, van der Velde ET, Jansen JR
Objective: To study the hypothesis that the electrical conductance of tissues and fluids (parallel conductance (G(p))) around the ventricle depends on left ventricular volume throughout the cardiac cycle. Methods: We extended a recently developed method to determine G(p) throughout the cardiac cycle. First, we compared the estimates of parallel conductances obtained with the new method (G(a)(p)) with those of the conventional one (G(1)(p)), both averaged over the cardiac cycles. Secondly, G(a)(p... Abstract
Cited 8 times since 2000 (0.3 per year) source: EuropePMC
Cardiovascular research, Volume 48, Issue 3, 1 1 2000, Pages 455-463 A new approach to determine parallel conductance for left ventricular volume measurements. Kornet L, Schreuder JJ, van der Velde ET, Baan J, Jansen JR
Objectives: To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely. Methods: A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (G(a)(p)) were compared to those obtained with the conventional method (G(l)(p)).... Abstract