Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 33 times since 2021 (10.4 per year) source: Scopus
EClinicalMedicine, Volume 32, 28 4 2021, Pages 100731 Short-term outpatient follow-up of COVID-19 patients: A multidisciplinary approach. de Graaf MA, Antoni ML, Ter Kuile MM, Arbous MS, Duinisveld AJF, Feltkamp MCW, Groeneveld GH, Hinnen SCH, Janssen VR, Lijfering WM, Omara S, Postmus PE, Ramai SRS, Rius-Ottenheim N, Schalij MJ, Schiemanck SK, Smid L, Stöger JL, Visser LG, de Vries JJC, Wijngaarden MA, Geelhoed JJM, Roukens AHE
Background: Short-term follow-up of COVID-19 patients reveals pulmonary dysfunction, myocardial damage and severe psychological distress. Little is known of the burden of these sequelae, and there are no clear recommendations for follow-up of COVID-19 patients.In this multi-disciplinary evaluation, cardiopulmonary function and psychological impairment after hospitalization for COVID-19 are mapped. Methods: We evaluated patients at our outpatient clinic 6 weeks after discharge. Cardiopulmonary fu... Abstract
Cited 8 times since 2021 (2.5 per year) source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 32, Issue 4, 18 3 2021, Pages 720-726 Safety and effectiveness of omalizumab for the treatment of chronic urticaria in pediatric patients. Dekkers C, Alizadeh Aghdam M, de Graaf M, Knulst AC, Meijer Y, van den Reek JMPA, Stadermann MB, Röckmann H
Background: Evidence on safety and effectiveness of omalizumab for treatment of chronic urticaria in pediatric patients is scarce and limited to case reports. In particular, drug survival of omalizumab has not yet been investigated, which is a key element in the evaluation of its clinical performance. The aim of this study was to investigate safety, effectiveness, and drug survival rates of omalizumab in a daily practice cohort of pediatric patients with chronic urticaria (CU). Methods: This is... Abstract
Cited 3 times since 2021 (0.9 per year) source: EuropePMC
Journal of virology, Volume 95, Issue 3, 13 2 2021, Pages e01492-20 Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species. Villabruna N, Schapendonk CME, Aron GI, Koopmans MPG, de Graaf M
Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investigated the potential of animals to serve as a reservoir of human noroviruses by testing norovirus attachment to formalin-fixed intestinal tissues of a range of potential reservoir ani... Abstract
Cited 18 times since 2021 (5.6 per year) source: EuropePMC
Emerging infectious diseases, Volume 27, Issue 1, 1 1 2021, Pages 289-293 Detection of Norovirus Variant GII.4 Hong Kong in Asia and Europe, 2017-2019. Chan MC, Roy S, Bonifacio J, Zhang LY, Chhabra P, Chan JCM, Celma C, Igoy MA, Lau SL, Mohammad KN, Vinjé J, Vennema H, Breuer J, Koopmans M, de Graaf M, for NOROPATROL2
We report a new norovirus GII.4 variant, GII.4 Hong Kong, with low-level circulation in 4 Eurasia countries since mid-2017. Amino acid substitutions in key residues on the virus capsid associated with the emergence of pandemic noroviruses suggest that GII.4 Hong Kong has the potential to become the next pandemic variant. Abstract
Cited 10 times since 2020 (3 per year) source: EuropePMC
European journal of pediatrics, Volume 180, Issue 2, 2 1 2020, Pages 617-625 Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study. El Manouni El Hassani S, Niemarkt HJ, Derikx JPM, Berkhout DJC, Ballón AE, de Graaf M, de Boode WP, Cossey V, Hulzebos CV, van Kaam AH, Kramer BW, van Lingen RA, Vijlbrief DC, van Weissenbruch MM, Benninga MA, de Boer NKH, de Meij TGJ
Necrotizing enterocolitis (NEC) is one of the most common and lethal gastrointestinal diseases in preterm infants. Early recognition of infants in need for surgical intervention might enable early intervention. In this multicenter case-control study, performed in nine neonatal intensive care units, preterm born infants (< 30 weeks of gestation) diagnosed with NEC (stage ≥ IIA) between October 2014 and August 2017 were divided into two groups: (1) medical (conservative treatment) and (2) surgi... Abstract
Cited 19 times since 2020 (5.6 per year) source: EuropePMC
Cell reports. Medicine, Volume 1, Issue 9, 10 2 2020, Pages 100146 Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons. Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea MG, Vermeulen M, van der Vlag J, Duivenvoorden R
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Can... Abstract
Cited 11 times since 2020 (3.2 per year) source: EuropePMC
The journal of allergy and clinical immunology. In practice, Volume 9, Issue 3, 7 1 2020, Pages 1389-1392.e2 Long-term follow-up and treatment outcomes of conjunctivitis during dupilumab treatment in patients with moderate-to-severe atopic dermatitis. Achten R, Bakker D, Ariens L, Lans A, Thijs J, van der Schaft J, de Boer J, Balak D, de Graaf M, van Luijk C, de Bruin-Weller M
Cited 81 times since 2020 (23.3 per year) source: EuropePMC
Frontiers in immunology, Volume 11, 6 1 2020, Pages 575047 Increased Plasma Heparanase Activity in COVID-19 Patients. Buijsers B, Yanginlar C, de Nooijer A, Grondman I, Maciej-Hulme ML, Jonkman I, Janssen NAF, Rother N, de Graaf M, Pickkers P, Kox M, Joosten LAB, Nijenhuis T, Netea MG, Hilbrands L, van de Veerdonk FL, Duivenvoorden R, de Mast Q, van der Vlag J
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Low molecular weight heparins (LMWH) serve as an inhibitor of heparanase. We hypothesize that heparanase contributes to the pathogenesis of COVID-19, and that heparanase may be inhibited by LMWH. To test this hypothesis, heparanase activity and heparan sulfate le... Abstract
Nature, Volume 585, Issue 7825, 1 1 2020, Pages E11 Author Correction: Global status and conservation potential of reef sharks. MacNeil MA, Chapman DD, Heupel M, Simpfendorfer CA, Heithaus M, Meekan M, Harvey E, Goetze J, Kiszka J, Bond ME, Currey-Randall LM, Speed CW, Sherman CS, Rees MJ, Udyawer V, Flowers KI, Clementi G, Valentin-Albanese J, Gorham T, Adam MS, Ali K, Pina-Amargós F, Angulo-Valdés JA, Asher J, Barcia LG, Beaufort O, Benjamin C, Bernard ATF, Berumen ML, Bierwagen S, Bonnema E, Bown RMK, Bradley D, Brooks E, Brown JJ, Buddo D, Burke P, Cáceres C, Cardeñosa D, Carrier JC, Caselle JE, Charloo V, Claverie T, Clua E, Cochran JEM, Cook N, Cramp J, D'Alberto B, de Graaf M, Dornhege M, Estep A, Fanovich L, Farabaugh NF, Fernando D, Flam AL, Floros C, Fourqurean V, Garla R, Gastrich K, George L, Graham R, Guttridge T, Hardenstine RS, Heck S, Henderson AC, Hertler H, Hueter R, Johnson M, Jupiter S, Kasana D, Kessel ST, Kiilu B, Kirata T, Kuguru B, Kyne F, Langlois T, Lédée EJI, Lindfield S, Luna-Acosta A, Maggs J, Manjaji-Matsumoto BM, Marshall A, Matich P, McCombs E, McLean D, Meggs L, Moore S, Mukherji S, Murray R, Kaimuddin
An Amendment to this paper has been published and can be accessed via a link at the top of the paper. Abstract
Cited 40 times since 2020 (10.8 per year) source: EuropePMC
Nature, Volume 583, Issue 7818, 22 4 2020, Pages 801-806 Global status and conservation potential of reef sharks. MacNeil MA, Chapman DD, Heupel M, Simpfendorfer CA, Heithaus M, Meekan M, Harvey E, Goetze J, Kiszka J, Bond ME, Currey-Randall LM, Speed CW, Sherman CS, Rees MJ, Udyawer V, Flowers KI, Clementi G, Valentin-Albanese J, Gorham T, Adam MS, Ali K, Pina-Amargós F, Angulo-Valdés JA, Asher J, Barcia LG, Beaufort O, Benjamin C, Bernard ATF, Berumen ML, Bierwagen S, Bonnema E, Bown RMK, Bradley D, Brooks E, Brown JJ, Buddo D, Burke P, Cáceres C, Cardeñosa D, Carrier JC, Caselle JE, Charloo V, Claverie T, Clua E, Cochran JEM, Cook N, Cramp J, D'Alberto B, de Graaf M, Dornhege M, Estep A, Fanovich L, Farabaugh NF, Fernando D, Flam AL, Floros C, Fourqurean V, Garla R, Gastrich K, George L, Graham R, Guttridge T, Hardenstine RS, Heck S, Henderson AC, Hertler H, Hueter R, Johnson M, Jupiter S, Kasana D, Kessel ST, Kiilu B, Kirata T, Kuguru B, Kyne F, Langlois T, Lédée EJI, Lindfield S, Luna-Acosta A, Maggs J, Manjaji-Matsumoto BM, Marshall A, Matich P, McCombs E, McLean D, Meggs L, Moore S, Mukherji S, Murray R, Kaimuddin
Decades of overexploitation have devastated shark populations, leaving considerable doubt as to their ecological status1,2. Yet much of what is known about sharks has been inferred from catch records in industrial fisheries, whereas far less information is available about sharks that live in coastal habitats3. Here we address this knowledge gap using data from more than 15,000 standardized baited remote underwater video stations that were deployed on 371 reefs in 58 nations to estimate the conse... Abstract
Cited 8 times since 2020 (2.1 per year) source: EuropePMC
One health outlook, Volume 2, 22 4 2020, Pages 14 Novel opportunities for NGS-based one health surveillance of foodborne viruses. Desdouits M, de Graaf M, Strubbia S, Oude Munnink BB, Kroneman A, Le Guyader FS, Koopmans MPG
Foodborne viral infections rank among the top 5 causes of disease, with noroviruses and hepatitis A causing the greatest burden globally. Contamination of foods by infected food handlers or through environmental pollution are the main sources of foodborne illness, with a lesser role for consumption of products from infected animals. Viral partial genomic sequencing has been used for more than two decades to track foodborne outbreaks and whole genome or metagenomics next-generation-sequencing (NG... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Journal of the American Academy of Dermatology, Volume 84, Issue 4, 12 2 2020, Pages 1111-1113 Collodion babies: A 15-year retrospective multicenter study in The Netherlands-Evaluation of severity scores to predict the underlying disease. Cuperus E, Bolling MC, de Graaf M, van den Akker PC, van Gijn ME, Simon MEH, Sigurdsson V, Pasmans SGMA
Cited 4 times since 2020 (1 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 9, 12 2 2020, Pages 1073-1085 RV Tissue Heterogeneity on CT: A Novel Tool to Identify the VT Substrate in ARVC. Venlet J, Tao Q, de Graaf MA, Glashan CA, de Riva Silva M, van der Geest RJ, Scholte AJ, Piers SRD, Zeppenfeld K
Objectives: This study sought to evaluate whether right ventricular (RV) tissue heterogeneity on computed tomography (CT): 1) is associated with conduction delay in arrhythmogenic right ventricular cardiomyopathy (ARVC); and 2) distinguishes patients with ARVC from those with exercise-induced arrhythmogenic remodeling (EIAR) and control individuals. Background: ARVC is characterized by fibrofatty replacement, related to conduction delay and ventricular tachycardias. Distinguishing ARVC from acqu... Abstract
Cited 10 times since 2020 (2.6 per year) source: EuropePMC
Allergy, Volume 75, Issue 9, 5 1 2020, Pages 2376-2379 Two-year drug survival of dupilumab in a large cohort of difficult-to-treat adult atopic dermatitis patients compared to cyclosporine A and methotrexate: Results from the BioDay registry. Spekhorst LS, Ariëns LFM, van der Schaft J, Bakker DS, Kamsteeg M, Oosting AJ, de Ridder I, Sloeserwij A, Romeijn GLE, de Graaf M, Haeck I, Thijs JL, Schuttelaar MLA, de Bruin-Weller MS
Cited 7 times since 2020 (1.8 per year) source: EuropePMC
JMIR research protocols, Volume 9, Issue 5, 1 1 2020, Pages e17419 Improving Hand Hygiene Compliance in Nursing Homes: Protocol for a Cluster Randomized Controlled Trial (HANDSOME Study). Teesing GR, Erasmus V, Petrignani M, Koopmans MPG, de Graaf M, Vos MC, Klaassen CHW, Verduijn-Leenman A, Schols JMGA, Richardus JH, Voeten HACM
Background: Hand hygiene compliance is considered the most (cost-)effective measure for preventing health care-associated infections. While hand hygiene interventions have frequently been implemented and assessed in hospitals, there is limited knowledge about hand hygiene compliance in other health care settings and which interventions and implementation methods are effective. Objective: This study aims to evaluate the effect of a multimodal intervention to increase hand hygiene compliance of nu... Abstract
Cited 988 times since 2020 (252.6 per year) source: EuropePMC
Science (New York, N.Y.), Volume 369, Issue 6499, 1 1 2020, Pages 50-54 SARS-CoV-2 productively infects human gut enterocytes. Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RBG, Paul van Schayck J, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJH, Schipper D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL, Clevers H
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocyt... Abstract
Cited 4 times since 2020 (1 per year) source: EuropePMC
Zoonoses and public health, Volume 67, Issue 4, 9 2 2020, Pages 453-459 Norovirus outbreak in a natural playground: A One Health approach. Sips GJ, Dirven MJG, Donkervoort JT, van Kolfschoten FM, Schapendonk CME, Phan MVT, Bloem A, van Leeuwen AF, Trompenaars ME, Koopmans MPG, van der Eijk AA, de Graaf M, Fanoy EB
Norovirus constitutes the most frequently identified infectious cause of disease outbreaks associated with untreated recreational water. When investigating outbreaks related to surface water, a One Health approach is insightful. Historically, there has been a focus on potential contamination of recreational water by bird droppings and a recent publication demonstrating human noroviruses in bird faeces suggested this should be investigated in future water-related norovirus outbreaks. Here, we des... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Ocular immunology and inflammation, Volume 28, Issue 7, 16 3 2020, Pages 1049-1055 Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients. Smit D, De Graaf M, Meyer D, de Groot-Mijnes JDF
Purpose: To evaluate immunoblot (IB) and polymerase chain reaction (PCR) to diagnose ocular- and neurosyphilis. Methods: Prospective cross-sectional study. Aqueous humor (AH) and cerebrospinal fluid (CSF) samples were tested for treponemal DNA or antibodies to treponemal antigens. Results: Thirteen of 106 cases had positive syphilis serology of which 69.2% were HIV+ (median CD4+ = 181 cells/µL). Four cases met CDC criteria for neurosyphilis (3 confirmed, 1 probable) and 2 additional cases requir... Abstract
Cited 26 times since 2019 (5.9 per year) source: EuropePMC
Cardiovascular diabetology, Volume 18, Issue 1, 31 5 2019, Pages 144 Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina. Caselli C, Del Turco S, Ragusa R, Lorenzoni V, De Graaf M, Basta G, Scholte A, De Caterina R, Neglia D
Objective: Aim of this study was to evaluate the relationship of plasma PCSK9 with metabolic and inflammatory profile and coronary atherosclerotic burden in patients with suspected CAD enrolled in the EVINCI study. Methods: PCSK9 was measured in 539 patients (60.3 ± 8.6 years, 256 males) with symptoms of CAD characterized by risk factors, bio-humoral profiles, and treatment. N = 412 patients underwent coronary computed tomography angiography (CTA) to assess the presence and characteristics of co... Abstract
Cited 14 times since 2019 (3.1 per year) source: EuropePMC
Frontiers in microbiology, Volume 10, 17 3 2019, Pages 2394 Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters. Strubbia S, Schaeffer J, Oude Munnink BB, Besnard A, Phan MVT, Nieuwenhuijse DF, de Graaf M, Schapendonk CME, Wacrenier C, Cotten M, Koopmans MPG, Le Guyader FS
Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present in such complex matrices, method optimization is still needed. This work presents methodological developments focused on norovirus, a small ssRNA non-enveloped virus known as the major cause of human gastroenteritis worldwide and frequently present... Abstract