Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
237 results
Cited 11 times since 2013 (1.1 per year) source: EuropePMC
Arrhythmia & electrophysiology review, Volume 2, Issue 2, 29 5 2013, Pages 128-134 Imaging-guided Ventricular Tachycardia Ablation. Piers SR, Zeppenfeld K
Over the past decades important advances have been made in the field of ventricular tachycardia (VT) ablation, and as a result, VT ablation is now more widely being performed. The identification of ablation target sites still relies on electroanatomical substrate mapping, which is time-consuming, hampered by the intramural location of some scars and limited by epicardial fat. The potential of various imaging modalities to overcome these limitations have stimulated clinical electrophysiologists t... Abstract
Cited 70 times since 2013 (6.6 per year) source: EuropePMC
Circulation, Volume 128, Issue 21, 13 2 2013, Pages 2289-2295 Initial human feasibility of infusion needle catheter ablation for refractory ventricular tachycardia. Sapp JL, Beeckler C, Pike R, Parkash R, Gray CJ, Zeppenfeld K, Kuriachan V, Stevenson WG
Background: Ablation of ventricular tachycardia (VT) is sometimes unsuccessful when ablation lesions are of insufficient depth to reach arrhythmogenic substrate. We report the initial experience with the use of a catheter with an extendable/retractable irrigated needle at the tip capable of intramyocardial mapping and ablation. Methods and results: Sequential consenting patients with recurrent VT underwent ablation with the use of a needle-tipped catheter. At target sites, the needle was advance... Abstract
Cited 70 times since 2013 (6.6 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 5, 13 2 2013, Pages 875-883 Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy. Piers SR, Tao Q, van Huls van Taxis CF, Schalij MJ, van der Geest RJ, Zeppenfeld K
Background: There are limited data on typical arrhythmogenic substrates and associated ventricular tachycardias (VT) in patients with nonischemic cardiomyopathy. The substrate location may have implications for the ablation strategy. Methods and results: Nineteen consecutive patients with nonischemic cardiomyopathy (age 58±14 years, 79% men, left ventricular ejection fraction 41±11%) who underwent contrast-enhanced MRI and VT ablation were included. On the basis of 3-dimensional contrast-enhance... Abstract
Cited 41 times since 2013 (3.8 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 62, Issue 13, 10 2 2013, Pages 1195-1202 Neurohormonal, structural, and functional recovery pattern after premature ventricular complex ablation is independent of structural heart disease status in patients with depressed left ventricular ejection fraction: a prospective multicenter study. Penela D, Van Huls Van Taxis C, Van Huls Vans Taxis C, Aguinaga L, Fernández-Armenta J, Mont L, Castel MA, Heras M, Tolosana JM, Sitges M, Ordóñez A, Brugada J, Zeppenfeld K, Berruezo A
Objectives: This study aimed to assess the benefit after ablation of premature ventricular complexes (PVC) in patients with frequent PVC and left ventricular (LV) dysfunction, regardless of previous structural heart disease (SHD) diagnosis, PVC morphology, or estimated site of origin. Background: Ablation of PVC in patients with LV dysfunction is usually restricted to patients with suspected PVC-induced cardiomyopathy. Methods: Consecutive patients with frequent PVC and LV dysfunction accepted f... Abstract
Cited 51 times since 2013 (4.7 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 3, 25 4 2013, Pages 513-521 Outcome of ventricular tachycardia ablation in patients with nonischemic cardiomyopathy: the impact of noninducibility. Piers SR, Leong DP, van Huls van Taxis CF, Tayyebi M, Trines SA, Pijnappels DA, Delgado V, Schalij MJ, Zeppenfeld K
Background: Ablation failure and recurrence rates after ventricular tachycardia (VT) ablation in nonischemic cardiomyopathy are high and the optimal procedural end point is not well defined. This study assessed the outcome after ablation, the impact of noninducibility, and other potential predictors of VT recurrence. Methods and results: Forty-five patients with nonischemic cardiomyopathy (60±16 years; left ventricular ejection fraction, 44±14%) accepted for VT ablation were included. Epicardial... Abstract
Cited 8 times since 2013 (0.7 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 5, 22 4 2013, Pages 690-696 Duty-cycled bipolar/unipolar radiofrequency ablation for symptomatic atrial fibrillation induces significant pulmonary vein narrowing at long-term follow-up. Compier MG, Leong DP, Marsan NA, Delgado V, Zeppenfeld K, Schalij MJ, Trines SA
Aims: A novel duty-cycled bipolar/unipolar ablation catheter pulmonary vein ablation catheter (PVAC) has been developed to achieve pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). Ablation with PVAC was recently found to induce PV narrowing at 3 months follow-up. The long-term effects of this catheter on PV dimensions are however unknown and were evaluated with this study. Methods and results: Patients (n = 62, 71% male, age 60 ± 7 years) with drug-refractory AF scheduled... Abstract
Cited 32 times since 2013 (2.8 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 6, Issue 1, 1 1 2013, Pages 42-52 Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K
Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries... Abstract
Cited 3 times since 2013 (0.3 per year) source: EuropePMC
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Volume 16, Issue Pt 3, 1 1 2013, Pages 147-154 Improved myocardial scar characterization by super-resolution reconstruction in late gadolinium enhanced MRI. Dzyubachyk O, Tao Q, Poot DH, Lamb H, Zeppenfeld K, Lelieveldt BP, van der Geest RJ
Image resolution is an important factor for accurate myocardial scar assessment from late gadolinium enhanced (LGE) MR. It has been shown that the conventionally used short-axis (SA) LGE acquisition with anisotropic resolution may overestimate the scar size due to partial volume effect, undermining the prognostic and diagnostic accuracy of LGE MRI in critical clinical applications. In this work, we present a method for combining three complementary anisotropic orthogonal LGE sequences of the hea... Abstract
Cited 18 times since 2013 (1.6 per year) source: EuropePMC
Indian pacing and electrophysiology journal, Volume 13, Issue 1, 1 1 2013, Pages 14-33 Radiofrequency catheter ablation of idiopathic right ventricular outflow tract arrhythmias. Calvo N, Jongbloed M, Zeppenfeld K
Idiopathic ventricular arrhythmias (VA) consist of various subtypes of VA that occur in the absence of clinically apparent structural heart disease. Affected patients account for approximately 10% of all patients referred for evaluation of ventricular tachycardia (VT). Arrhythmias arising from the outflow tract (OT) are the most common subtype of idiopathic VA and more than 70-80% of idiopathic VTs or premature ventricular contractions (PVCs) originate from the right ventricular (RV) OT. Idiopat... Abstract
Cited 35 times since 2012 (3.1 per year) source: EuropePMC
European heart journal, Volume 34, Issue 8, 15 3 2012, Pages 586-596 Epicardial substrate mapping for ventricular tachycardia ablation in patients with non-ischaemic cardiomyopathy: a new algorithm to differentiate between scar and viable myocardium developed by simultaneous integration of computed tomography and contrast-enhanced magnetic resonance imaging. Piers SR, van Huls van Taxis CF, Tao Q, van der Geest RJ, Askar SF, Siebelink HM, Schalij MJ, Zeppenfeld K
Aims: During epicardial electroanatomical mapping (EAM), it is difficult to differentiate between fibrosis and fat, as both exhibit attenuated bipolar voltage (BV). The purpose of this study was to assess whether unipolar voltage (UV), BV, and electrogram characteristics (EC) can distinguish fibrosis from viable myocardium and fat during epicardial EAM for ventricular tachycardia (VT) ablation in non-ischaemic cardiomyopathy (NICM). Methods and results: Ten NICM patients (7 males, 56 ± 13 years)... Abstract
Cited 49 times since 2012 (4.3 per year) source: EuropePMC
Heart rhythm, Volume 10, Issue 2, 13 2 2012, Pages 158-164 Electrophysiological characteristics of ventricular tachyarrhythmias in cardiac sarcoidosis versus arrhythmogenic right ventricular cardiomyopathy. Dechering DG, Kochhäuser S, Wasmer K, Zellerhoff S, Pott C, Köbe J, Spieker T, Piers SR, Bittner A, Mönnig G, Breithardt G, Wichter T, Zeppenfeld K, Eckardt L
Background: Recent evidence suggests that cardiac sarcoidosis (CS) and arrhythmogenic right ventricular cardiomyopathy (ARVC) can manifest very similarly. Objective: To investigate whether there are significant demographic and electrophysiological differences between patients with CS and ARVC. Methods: We prospectively compared patients with proven CS or ARVC who underwent radiofrequency catheter ablation of ventricular tachycardias by using 3-dimensional electroanatomical mapping. Furthermore,... Abstract
Cited 12 times since 2012 (1 per year) source: EuropePMC
Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 171-181 Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms. Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA
Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 14, Issue 3, 19 3 2012, Pages 247-252 Impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Boogers MJ, Compier M, Trines SA, Scholte AJ, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V
Aims: Coronary atherosclerosis has been associated with the development of atrial fibrillation (AF). However, little is known about the impact of coronary atherosclerosis on the outcome treatment of AF. The aim of this study was to investigate the impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation (RFCA) for AF using multi-detector row computed tomography (MDCT). Methods: In 125 consecutive patients undergoing RFCA for AF, a pre-procedural MDCT examination (co... Abstract
Cited 2 times since 2012 (0.2 per year) source: EuropePMC
International journal of computer assisted radiology and surgery, Volume 7, Issue 5, 3 1 2012, Pages 753-767 Cardiac MRI visualization for ventricular tachycardia ablation. Godeschalk-Slagboom CJ, van der Geest RJ, Zeppenfeld K, Botha CP
Objective: The integrated visualization of cardiac MRI during a ventricular tachycardia (VT) mapping and ablation procedure would provide improved catheter guidance and tissue assessment. We developed a system for and explored the added value of simultaneous visualization of intracardiac voltage measurements and MRI-derived myocardial scar information during VT ablation procedures. Method: We propose the use of a synchronized 3D and 2D view. In 3D, the catheter will be guided optimally by assess... Abstract
Cited 15 times since 2012 (1.2 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 2, 1 1 2012, Pages e38-40 Bipolar ablation of ventricular tachycardia in a patient after atrial switch operation for dextro-transposition of the great arteries. Piers SR, Dyrda K, Tao Q, Zeppenfeld K
Cited 3 times since 2012 (0.2 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 6, 29 5 2012, Pages 778-780 Ventricular tachycardia ablation in implantable cardioverter-defibrillator recipients: a need to catch up with current recommendations. Zeppenfeld K
Cited 18 times since 2012 (1.5 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 7, Issue 9, 1 1 2012, Pages 1021-1029 Five-year clinical follow-up from the MISSION! Intervention Study: sirolimus-eluting stent versus bare metal stent implantation in patients with ST-segment elevation myocardial infarction, a randomised controlled trial. Boden H, van der Hoeven BL, Liem SS, Atary JZ, Cannegieter SC, Atsma DE, Bootsma M, Jukema JW, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ
Aims: To evaluate the clinical outcomes of sirolimus-eluting stent (SES) versus bare metal stent (BMS) implantation in patients with ST-segment elevation myocardial infarction (STEMI) at long-term follow-up. Methods and results: After five years, 310 STEMI patients randomly assigned to implantation of either SES or BMS, were compared. Survival rates were comparable between groups (SES 94.3% vs. BMS 92.8%, p=0.57), as were the rates of reinfarction (10.6% vs. 13.7%, p=0.40), freedom of death/re-M... Abstract
Cited 33 times since 2011 (2.7 per year) source: EuropePMC
Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA
Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract
The international journal of cardiovascular imaging, Volume 27, Issue 7, 1 1 2011, Pages 989-993 CMR-determined scar volume: predictive for ventricular tachycardias? van der Wall EE, Zeppenfeld K, Bax JJ, Siebelink HM, Schalij MJ
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 23, Issue 1, 13 2 2011, Pages 74-80 Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods. Tao Q, Milles J, VAN Huls VAN Taxis C, Lamb HJ, Reiber JH, Zeppenfeld K, VAN DER Geest RJ
Introduction: Integration of preprocedural delayed enhanced magnetic resonance imaging (DE-MRI) with electroanatomical voltage mapping (EAVM) may provide additional high-resolution substrate information for catheter ablation of scar-related ventricular tachycardias (VT). Accurate and fast image integration of DE-MRI with EAVM is desirable for MR-guided ablation. Methods and results: Twenty-six VT patients with large transmural scar underwent catheter ablation and preprocedural DE-MRI. With diffe... Abstract