Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
53 results
The American journal of medicine, Volume 100, Issue 4, 1 1 1996, Pages 478-479 Arthritis and hypergammaglobulinemic purpura in hypersensitivity pneumonitis. Oosterkamp HM, van der Pijl H, Derksen J, Willems LN, de Meijer PH
Cited 25 times since 1996 (0.9 per year) source: EuropePMC
Behaviour research and therapy, Volume 34, Issue 4, 1 1 1996, Pages 333-340 Is there a specific relationship between asthma and panic disorder? Van Peski-Oosterbaan AS, Spinhoven P, Van der Does AJ, Willems LN, Sterk PJ
The objective of the present study was three-fold: (1) to assess the prevalence of PD in asthmatic patients in comparison with non-asthmatic patients; (2) to investigate possible differences in pulmonary function and anxiety symptomatology between asthmatic patients with PD and those without; and (3) to evaluate possible differences in symptom perception during histamine-induced bronchoconstriction between asthmatic patients with PD versus asthmatic controls without PD matched for age, sex and b... Abstract
Cited 35 times since 1992 (1.1 per year) source: EuropePMC
Radiology, Volume 182, Issue 2, 1 1 1992, Pages 375-379 Early diagnosis of cor pulmonale with MR imaging of the right ventricle. Pattynama PM, Willems LN, Smit AH, van der Wall EE, de Roos A
Right ventricular (RV) wall volumes, chamber volumes, and RV ejection fractions were assessed by means of magnetic resonance (MR) imaging in 17 patients with moderate chronic obstructive lung disease and in 11 healthy subjects. Short-axis spin-echo or gradient-echo images encompassing the entire right ventricle were obtained. The mean RV wall mass in patients was significantly higher than that in healthy subjects (61 g +/- 13 [standard deviation] vs 47 g +/- 7, P = .005), while the ejection frac... Abstract
Cited 9 times since 1991 (0.3 per year) source: EuropePMC
The European respiratory journal, Volume 4, Issue 3, 1 1 1991, Pages 316-323 Lack of type II cells and emphysema in human lungs. Otto-Verberne CJ, Ten Have-Opbroek AA, Willems LN, Franken C, Kramps JA, Dijkman JH
Ten surgically removed human lungs or lobes were studied, to assess the relationship between the abundance of type II alveolar epithelial cells and the degree of emphysema. Type II cell abundance (total number as well as percentage of the total parenchymal cell population) was determined in sections of randomly selected tissue samples of these lungs or lobes by using a type II cell specific antibody specific anti-lavage serum (SALS-Hu), which recognizes surfactant-associated proteins. In these t... Abstract
Cited 15 times since 1991 (0.4 per year) source: EuropePMC
Annals of the New York Academy of Sciences, Volume 624, 1 1 1991, Pages 97-108 Role of antileukoprotease in the human lung. Kramps JA, Rudolphus A, Stolk J, Willems LN, Dijkman JH
Cited 16 times since 1990 (0.5 per year) source: EuropePMC
Thorax, Volume 45, Issue 2, 1 1 1990, Pages 89-94 Relation between small airways disease and parenchymal destruction in surgical lung specimens. Willems LN, Kramps JA, Stijnen T, Sterk PJ, Weening JJ, Dijkman JH
The relation between small airways disease and parenchymal destruction was investigated in lungs and lobes removed at surgery from 27 patients aged 15-70 years. Eight of the 27 patients were life-long non-smokers. The degree of small airways disease was assessed by semi-quantitative grading (SAD score) and by measuring diameter and wall thickness of membranous bronchioles. Parenchymal destruction was measured in three ways. Firstly, the number of alveolar attachments on membranous bronchioles pe... Abstract
Cited 18 times since 1989 (0.5 per year) source: EuropePMC
The American review of respiratory disease, Volume 139, Issue 5, 1 1 1989, Pages 1244-1250 Antileukoprotease-containing bronchiolar cells. Relationship with morphologic disease of small airways and parenchyma. Willems LN, Kramps JA, Stijnen T, Sterk PJ, Weening JJ, Dijkman JH
Twenty-seven surgically removed lungs and lobes were studied to assess the relation between the abundance of bronchiolar epithelial cells containing antileukoprotease (ALP) (ALP-pos/mm) and the degree of small airways disease (SADscore) and emphysema (destructive index = DI, and number of normal alveolar attachments on membranous bronchioles = normal AA/min). Between subjects, ALPpos/mm correlated with SADscore in membranous bronchioles (rs = 0.75; p less than 0.001) and with normal AA/mm (rs =... Abstract
Cited 3 times since 1988 (0.1 per year) source: EuropePMC
Thorax, Volume 43, Issue 10, 1 1 1988, Pages 784-786 Antileucoprotease in the developing fetal lung. Willems LN, Kramps JA, Jeffery PK, Dijkman JH
The distribution of antileucoprotease in the lungs of 25 fetuses of 9-40 weeks' gestation was studied with monoclonal antibodies and an indirect immunoperoxidase technique. Antileucoprotease was detected from 16 weeks in submucosal glands and collecting ducts in the trachea and main and lobar bronchi: it was also found in the surface epithelium of the trachea at 20 weeks, in main and lobar bronchi at 20 weeks, and in smaller bronchi at 20-25 weeks. Non-ciliated cells containing antileucopro... Abstract
Cited 21 times since 1988 (0.6 per year) source: EuropePMC
The American review of respiratory disease, Volume 138, Issue 2, 1 1 1988, Pages 321-326 Comparison of maximal bronchoconstriction in vivo and airway smooth muscle responses in vitro in nonasthmatic humans. de Jongste JC, Sterk PJ, Willems LN, Mons H, Timmers MC, Kerrebijn KF
We tested the hypothesis that maximal bronchoconstriction in humans in vivo is limited by the maximal contractility of airway smooth muscle by comparison of complete in vivo and in vitro dose-response curves to methacholine in 10 nonasthmatic subjects who were scheduled for thoracotomy because of malignancies. The provocative dose of methacholine that produced a 10 and 20% decrease of baseline FEV1 (PD10,20 FEV1) and the maximal fall in FEV1 (MFEV1) at the response plateau to inhaled methacholin... Abstract
Cited 7 times since 1988 (0.2 per year) source: EuropePMC
Biological chemistry Hoppe-Seyler, Volume 369 Suppl, 1 1 1988, Pages 83-87 Antileukoprotease, its role in the human lung. Kramps JA, Willems LN, Franken C, Dijkman JH
The number of antileukoprotease-containing epithelial cells in the bronchioles of 27 surgically removed lungs shows a close positive correlation with inflammation of the small airways (bronchioles) and an inverse correlation with the number of undamaged alveolar walls surrounding the bronchioles. So, more antileukoprotease-producing cells are present when bronchioles and adjacent alveoli are more diseased. These results suggest that antileukoprotease-producing cells constitute part of the inflam... Abstract
Cited 5 times since 1986 (0.1 per year) source: EuropePMC
European journal of respiratory diseases, Volume 69, Issue 4, 1 1 1986, Pages 242-247 Evaluation of antileukoprotease in surgical lung specimens. Willems LN, Kramps JA, de Water R, Stijnen T, Fleuren GJ, Franken C, Dijkman JH
To evaluate the presence of antileukoprotease in the lung and its possible contribution to parenchymal protection, surgically removed lungs or lobes of 41 patients were studied. Tissue slices were stained immunohistochemically for antileukoprotease. Site and number of antileukoprotease-containing cells were recorded. To measure emphysema, the mean linear intercept of each slice was determined. Antileukoprotease was observed in bronchial epithelium and glands and in at least two types of noncilia... Abstract
Cited 66 times since 1986 (1.7 per year) source: EuropePMC
The American review of respiratory disease, Volume 133, Issue 5, 1 1 1986, Pages 882-890 Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. De Water R, Willems LN, Van Muijen GN, Franken C, Fransen JA, Dijkman JH, Kramps JA
The present report describes the ultrastructural localization of bronchial antileukoprotease (ALP) in human central and peripheral airways by using polyclonal as well as monoclonal ALP-specific antibodies in a two-step gold-labeling procedure. In the serous cells of bronchial glands, ALP could be demonstrated in secretory granules. These granules, among which 4 phenotypes could be distinguished morphologically in ultrathin sections, showed the following labeling patterns: phenotype I, which had... Abstract
Cited 20 times since 1986 (0.5 per year) source: EuropePMC
Histochemistry, Volume 86, Issue 2, 1 1 1986, Pages 165-168 Detection of antileukoprotease in connective tissue of the lung. Willems LN, Otto-Verberne CJ, Kramps JA, ten Have-Opbroek AA, Dijkman JH
An indirect immunofluorescence technique was applied to frozen sections of central and peripheral human lung tissue to search for extracellular localizations of antileukoprotease (ALP). Two monoclonal anti-ALP antibodies recognizing different epitopes and polyclonal anti-ALP antibodies were used. ALP was found to be localized along elastic fibers in alveolar septa, and also along elastic fibers in the walls of bronchi, bronchioles and blood vessels. Serous cells of bronchial submucosal glands sh... Abstract