Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
53 results
Cited 1 times since 2023 (1.6 per year) source: EuropePMC
BMC pulmonary medicine, Volume 23, Issue 1, 28 4 2023, Pages 314 The diagnostic accuracy of spirometry as screening tool for adult patients with a benign subglottic stenosis. Schuering JHC, Halperin IJY, Ninaber MK, Willems LNA, van Benthem PPG, Sjögren EV, Langeveld APM
Background: There is a considerable diagnostic delay in the diagnosis 'benign acquired subglottic stenosis in adults' (SGS, diagnosed by the reference standard, i.e. laryngo- or bronchoscopy). Patients are frequently misdiagnosed since symptoms of this rare disease may mimic symptoms of 'asthma.' The 'Expiratory Disproportion Index' (EDI) obtained by spirometry, may be a simple instrument to detect an SGS-patient. The aim of this study was to evaluate the diagnostic... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
The bone & joint journal, Volume 99-B, Issue 4, 1 1 2017, Pages 516-521 Epidermal growth factor receptor mutations should be considered as a prognostic factor for survival of patients with pathological fractures or painful bone metastases from non-small cell lung cancer. Willeumier JJ, van der Hoeven NM, Bollen L, Willems LN, Fiocco M, van der Linden YM, Dijkstra PD
Aims: This study aims to assess first, whether mutations in the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma (kRAS) genes are associated with overall survival (OS) in patients who present with symptomatic bone metastases from non-small cell lung cancer (NSCLC) and secondly, whether mutation status should be incorporated into prognostic models that are used when deciding on the appropriate palliative treatment for symptomatic bone metastases. Patients and methods: We studied 13... Abstract
Cited 19 times since 2016 (2.4 per year) source: EuropePMC
The European respiratory journal, Volume 48, Issue 2, 26 4 2016, Pages 393-402 Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells. den Otter I, Willems LN, van Schadewijk A, van Wijngaarden S, Janssen K, de Jeu RC, Sont JK, Sterk PJ, Hiemstra PS
Which inflammatory markers in the bronchial mucosa of asthma patients are associated with decline of lung function during 14 years of prospective follow-up?To address this question, 19 mild-to-moderate, atopic asthmatic patients underwent spirometry and bronchoscopy at baseline and after 14 years of follow-up (t=14). Baseline bronchial biopsies were analysed for reticular layer thickness, eosinophil cationic protein (EG2), mast cell tryptase (AA1), CD3, CD4 and CD8. Follow-up biopsies were stain... Abstract
Cited 12 times since 2015 (1.4 per year) source: EuropePMC
Allergy, Volume 70, Issue 10, 6 1 2015, Pages 1336-1339 T helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific Aspergillus antigens. Jolink H, de Boer R, Willems LN, van Dissel JT, Falkenburg JH, Heemskerk MH
Allergic bronchopulmonary aspergillosis (ABPA) is characterized by an allergic immunological response to Aspergillus fumigatus. In this study, we investigated whether certain Aspergillus antigens are more allergenic than others, as was postulated previously. We stimulated peripheral blood mononuclear cells from patients with ABPA with the classically described A. fumigatus allergens Aspf1, Aspf2, Aspf3, and Aspf4, as well as two other Aspergillus antigens, Crf1 and Catalase1. Activated CD4+ T ce... Abstract
Cited 3 times since 2015 (0.3 per year) source: EuropePMC
Lancet (London, England), Volume 385, Issue 9973, 1 1 2015, Pages 1150 Acute eosinophilic pneumonia after recent start of smoking. Brackel CL, Ropers FG, Vermaas-Fricot SF, Koens L, Willems LN, Rikkers-Mutsaerts ER
Cited 27 times since 2012 (2.3 per year) source: EuropePMC
Respiratory medicine, Volume 106, Issue 8, 11 2 2012, Pages 1170-1176 "Feelings are facts": illness perceptions in patients with lung cancer. Hoogerwerf MA, Ninaber MK, Willems LN, Kaptein AA
Given the high degree of psychosocial problems in patients with lung cancer, quality medical care would benefit from exploring and addressing and providing potential solutions for these problems. Patients with recently diagnosed non-small-cell lung cancer filled out a questionnaire that assessed illness perceptions and made a drawing of how they perceived their diseased lungs look. They also participated in an interview about the impact of lung cancer in their lives. Scores on the Brief Illness... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
Annals of the rheumatic diseases, Volume 71, Issue 4, 21 3 2011, Pages 627-628 Diagnostic value of performing chest x-rays in patients presenting with recent-onset arthritis. de Vries-Bouwstra JK, Huizinga TW, Willems LN, van der Helm-van Mil AH
Cited 11 times since 2011 (0.9 per year) source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 6, Issue 9, 1 1 2011, Pages 1510-1515 Transesophageal ultrasound-guided fine-needle aspiration for the mediastinal restaging of non-small cell lung cancer. von Bartheld MB, Versteegh MI, Braun J, Willems LN, Rabe KF, Annema JT
Introduction: Selected patients with stage III (N2/N3) non-small cell lung cancer (NSCLC) who are downstaged to N0 by chemoradiation therapy might benefit from subsequent surgical resection of the tumor. How mediastinal lymph nodes can be best reevaluated is subject of debate. Transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) is a minimally invasive technique to sample mediastinal nodes. We assessed sensitivity and false-negative rate of EUS-FNA for the mediastinal restaging of... Abstract
Cited 37 times since 2010 (2.7 per year) source: EuropePMC
The Journal of infection, Volume 62, Issue 1, 21 3 2010, Pages 93-100 β-D-glucan and S-adenosylmethionine serum levels for the diagnosis of Pneumocystis pneumonia in HIV-negative patients: a prospective study. de Boer MG, Gelinck LB, van Zelst BD, van de Sande WW, Willems LN, van Dissel JT, de Jonge R, Kroon FP
Objective: To prospectively assess the diagnostic utility of S-adenosylmethionine (AdoMet) and (1→3)-β-D-glucan (β-D-glucan) serum markers for Pneumocystis pneumonia (PCP) in HIV-negative patients. Methods: HIV-negative, immunocompromised patients suspected of PCP based on clinical presentation and chest imaging were included. PCP was confirmed or rejected by results of direct microscopy and/or real-time PCR on broncho-alveolar lavage (BAL) fluid. Measurement of serum β-D-glucan and AdoMet was p... Abstract
Cited 14 times since 2010 (1 per year) source: EuropePMC
Anatomical sciences education, Volume 3, Issue 5, 1 1 2010, Pages 249-253 The role of medical museums in contemporary medical education. Marreez YM, Willems LN, Wells MR
From the early 19th century until the most recent two decades, open-space and satellite museums featuring anatomy and pathology collections (collectively referred to as "medical museums") had leading roles in medical education. However, many factors have caused these roles to diminish dramatically in recent years. Chief among these are the great advances in information technology and web-based learning that are currently at play in every level of medical training. Some medical schools... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
Gastrointestinal endoscopy, Volume 71, Issue 1, 15 3 2009, Pages 210-212 Mediastinal-esophageal fistulae after EUS-FNA of tuberculosis of the mediastinum. von Bartheld MB, van Kralingen KW, Veenendaal RA, Willems LN, Rabe KF, Annema JT
Cited 50 times since 2008 (3.2 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 26, Issue 26, 1 1 2008, Pages 4276-4281 Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome. Titulaer MJ, Wirtz PW, Willems LN, van Kralingen KW, Smitt PA, Verschuuren JJ
Purpose: A small-cell lung carcinoma (SCLC) is found in 50% of patients with Lambert-Eaton myasthenic syndrome (LEMS). We evaluated screening to optimize screening strategy for SCLC. It is important to detect these tumors early in newly diagnosed patients with LEMS to offer optimal patient treatment. Patients and methods: A large nationwide cohort study of consecutive patients in the Netherlands, seen between 1990 and 2007, were screened for the presence of a tumor using chest x-ray, computed to... Abstract
Cited 20 times since 2008 (1.3 per year) source: EuropePMC
The European respiratory journal, Volume 32, Issue 5, 9 2 2008, Pages 1321-1327 Pleural drainage and pleurodesis: implementation of guidelines in four hospitals. Burgers JA, Kunst PW, Koolen MG, Willems LN, Burgers JS, van den Heuvel M
The aim of the present study was to evaluate the implementation of the 2003 Dutch guideline on the diagnosis and treatment of malignant pleural effusions, and the potential effect of the implementation on the clinical outcome of pleurodesis. All patients with malignant pleural effusion who had a pleural drain placed with the intention of performing pleurodesis were registered prospectively in four centres. Details of the procedure and fluid recurrence and survival data were noted. Patients with... Abstract
Cited 9 times since 2007 (0.5 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 43, Issue 16, 10 2 2007, Pages 2345-2350 Phase III study of cyclophosphamide, doxorubicin, and etoposide compared with carboplatin and paclitaxel in patients with extensive disease small-cell lung cancer. de Jong WK, Groen HJ, Koolen MG, Biesma B, Willems LN, Kwa HB, van Bochove A, van Tinteren H, Smit EF
The progression-free survival (PFS) of cyclophosphamide/doxorubicin/etoposide (CDE) and carboplatin/paclitaxel (CP) was compared in chemonaive patients with extensive disease small-cell lung cancer (ED-SCLC). A total of 203 patients were randomised to three-weekly CDE (n=102) or CP (n=101) for five cycles. Tumour response rates in CDE and CP were 60% and 61%. PFS of CP was 5.2 months, PFS of CDE 4.9 months (p=0.60). The major difference in toxicity between CDE and CP was grade 4 leukocytopaenia... Abstract
Cited 30 times since 2007 (1.7 per year) source: EuropePMC
Chest, Volume 131, Issue 1, 1 1 2007, Pages 53-59 Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD. Lapperre TS, Willems LN, Timens W, Rabe KF, Hiemstra PS, Postma DS, Sterk PJ
Background: The single-breath N(2) test (sbN(2)-test) is closely related to small airways pathology in resected lung specimens of smokers. We investigated whether uneven ventilation and airway closure are associated with specific markers of airway inflammation as obtained by bronchial biopsies, BAL, and induced sputum in patients with manifest COPD. Methods: Fifty-one patients with stable COPD not receiving corticosteroids were examined in a cross-sectional study (43 men; mean [SD] age, 63 +/- 8... Abstract
Cited 25 times since 2006 (1.4 per year) source: EuropePMC
Expert opinion on pharmacotherapy, Volume 7, Issue 10, 1 1 2006, Pages 1323-1336 Available treatment options for the management of Lambert-Eaton myasthenic syndrome. Verschuuren JJ, Wirtz PW, Titulaer MJ, Willems LN, van Gerven J
Lambert-Eaton myasthenic syndrome is a rare, but reasonably well-understood, antibody-mediated autoimmune disease that is caused by serum auto-antibodies and results in muscle weakness and autonomic dysfunction. One half of the patients have an idiopathic form, the other half a tumour-associated form of the disease. Three randomised trials and a large number of smaller clinical studies have resulted in a number of drugs becoming available for the treatment of Lambert-Eaton myasthenic syndrome. S... Abstract
Cited 80 times since 2005 (4.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 172, Issue 7, 4 1 2005, Pages 837-841 Bronchial CD8 cell infiltrate and lung function decline in asthma. van Rensen EL, Sont JK, Evertse CE, Willems LN, Mauad T, Hiemstra PS, Sterk PJ, AMPUL Study Group
Rationale: Patients with asthma have an accelerated decline in lung function, which can lead to irreversible airway obstruction. It is generally assumed that this is related to specific aspects of airway inflammation and/or remodeling. Objective: We investigated the prognostic significance of bronchial eosinophil and CD8+ cell counts and subepithelial reticular layer thickness for the subsequent decline in lung function in patients with asthma after 7.5 years of follow-up. Methods: In a prospect... Abstract
Cited 80 times since 2005 (4.3 per year) source: EuropePMC
JAMA, Volume 294, Issue 8, 1 1 2005, Pages 931-936 Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. Annema JT, Versteegh MI, Veseliç M, Welker L, Mauad T, Sont JK, Willems LN, Rabe KF
Context: Up to 40% of thoracotomies performed for non-small cell lung cancer are unnecessary, predominantly due to inaccurate preoperative detection of lymph node metastases and mediastinal tumor invasion (T4). Mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) target different mediastinal lymph node stations. In addition, EUS can identify tumor invasion in neighboring organs if tumors are located adjacent to the esop... Abstract
Cited 48 times since 2003 (2.4 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 42, Issue 3, 1 1 2003, Pages 311-318 Mediastinal restaging: EUS-FNA offers a new perspective. Annema JT, Veseliç M, Versteegh MI, Willems LN, Rabe KF
Study objective: We hypothesized that transoesophageal endoscopic ultrasound guided fine needle aspiration (EUS-FNA) has the potential to be a valuable and accurate new diagnostic technique for mediastinal restaging in non-small cell lung cancer (NSCLC) after induction chemotherapy. The current restaging modalities either have a low diagnostic accuracy (computed tomography (CT) scan of the thorax) or they are invasive, can be technically difficult and are therefore not commonly performed (remedi... Abstract
Annals of the rheumatic diseases, Volume 62, Issue 10, 1 1 2003, Pages 922 Case Number 27: Jaw claudication in Takayasu's disease. Jeurissen SE, Liauw L, Willems LN, Huizinga TW