Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 16 times since 2013 (1.4 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 3, 1 1 2013, Pages 113-117 Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ
Ebstein's anomaly is a rare congenital heart malformation characterised by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. Associated abnormalities of left ventricular morphology and function including left ventricular noncompaction (LVNC) have been observed. An association between Ebstein's anomaly with LVNC and mutations in the sarcomeric protein gene MYH7, encoding β-myosin heavy chain, has been shown by recent studies. This might... Abstract
Cited 63 times since 2013 (5.6 per year) source: EuropePMC
European journal of heart failure, Volume 15, Issue 6, 29 5 2013, Pages 690-698 Impact of bosentan on exercise capacity in adults after the Fontan procedure: a randomized controlled trial. Schuuring MJ, Vis JC, van Dijk AP, van Melle JP, Vliegen HW, Pieper PG, Sieswerda GT, de Bruin-Bon RH, Mulder BJ, Bouma BJ
Aims: An endothelin-1 receptor blocker, shown to be effective in patients with pulmonary arterial hypertension, might decrease pulmonary vascular resistance to increase cardiac filling and consequently improve exercise capacity in Fontan patients. Methods and results: This was a prospective, multicentre randomized open label trial in Fontan patients. One group received bosentan for 6 months. The other group did not receive study medication for the first 3 months, followed by bosentan for 6 month... Abstract
Cited 11 times since 2013 (1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 1, 1 1 2013, Pages 6-13 Myocardial bridging: what have we learned in the past and will new diagnostic modalities provide new insights? Bruschke AV, Veltman CE, de Graaf MA, Vliegen HW
The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for detecting myocardial bridging than CAG. Combining CTCA with invasive techniques such as CAG should make it possible to improve our understanding of the patho... Abstract
Cited 89 times since 2012 (7.9 per year) source: EuropePMC
Circulation, Volume 127, Issue 3, 17 3 2012, Pages 322-330 Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ
Background: The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. Methods and results: We conducted a multicenter, double-blind, parallel, randomized controlled trial of angiotensin II receptor blocker valsartan 160 mg twice daily compared with placebo in patients with a systemic right ventricle caused by congenitally or surgically corrected transposition of the great arteries. The primary end point was change in right ventricular eject... Abstract
Cited 19 times since 2012 (1.6 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 94, Issue 6, 13 2 2012, Pages 2077-2082 Mild residual pulmonary stenosis in tetralogy of fallot reduces risk of pulmonary valve replacement. van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, Holman ER, Blom NA, Roest AA
Background: Current surgical strategies that aim at preventing pulmonary regurgitation in patients with corrected tetralogy of Fallot (cToF) may result in a certain grade of residual pulmonary stenosis (PS). The clinical implications of a postoperative residual PS in cToF patients remain unclear. Pulmonary valve replacement (PVR) is frequently needed during follow-up of cToF patients. The aim of the current study was to determine the role of residual PS in the need for PVR during follow-up in cT... Abstract
Cited 1 times since 2012 (0.1 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 6, 12 2 2012, Pages 2836-2840 Impaired cardiac reserve in asymptomatic patients with moderate pulmonary restenosis late after relief of severe pulmonary stenosis: evidence for diastolic dysfunction. Romeih S, Blom NA, Van der Plas MN, Spijkerboer AM, Roest AA, Vliegen HW, Mulder BJ, Groenink M
Background: Patients with moderate pulmonary valve restenosis late after relief of severe pulmonary stenosis (PS) may show decreased exercise tolerance. To elucidate the mechanism of decreased exercise tolerance, we evaluated cardiac response to physical and pharmacological stress in these patients and compared results with those of patients with native moderate PS. Methods: Twenty asymptomatic patients with moderate PS were divided into 2 groups: Group I (late after relief of severe PS, n=9), a... Abstract
Cited 4 times since 2012 (0.3 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 6, 9 2 2012, Pages 2841-2845 Rates and determinants of progressive aortic valve dysfunction in aortic coarctation. Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ
Purpose: Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunction in CoA. Methods: 96 CoA patients prospectively underwent echocardiography twice between 2001 and 2010. AS was defined as an aortic valve gradient ≥ 20 mmHg, AR as none/minor, or... Abstract
Cited 126 times since 2012 (10.8 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 5, Issue 5, 8 2 2012, Pages 628-636 Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V
Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat... Abstract
Cited 21 times since 2012 (1.8 per year) source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society, Volume 101, Issue 7, 1 1 2012, Pages 509-519 Psychosocial impact of implantable cardioverter defibrillators (ICD) in young adults with Tetralogy of Fallot. Opić P, Utens EM, Moons P, Theuns DA, van Dijk AP, Hoendermis ES, Vliegen HW, de Groot NM, Witsenburg M, Schalij M, Roos-Hesselink JW
Objective: To investigate the psychosocial impact of having an implantable cardioverter defibrillator (ICD) in adults with Tetralogy of Fallot (ToF). Methods: Included were 26 ToF-patients with an ICD (age 44 ± 12 years), and two control groups consisting of 28 ToF-patients without an ICD (age 40 ± 10 years) and a group of 35 ICD-patients of older age without ToF (age 72.0 ± 8 years). This last control group was chosen to represent the "older general ICD population" with acquired heart... Abstract
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 25, Issue 6, 17 3 2012, Pages 674-681 Right ventricular longitudinal peak systolic strain measurements from the subcostal view in patients with suspected pulmonary hypertension: a feasibility study. Haeck ML, Scherptong RW, Antoni ML, Marsan NA, Vliegen HW, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: The assessment of right ventricular (RV) function with two-dimensional echocardiography can be challenging in patients with pulmonary hypertension, especially in those with chronic pulmonary disease. The aim of the present study was to evaluate the feasibility of measuring RV longitudinal peak systolic strain (LPSS) in the echocardiographic subcostal view in patients with suspected pulmonary hypertension. Methods: A total of 179 patients evaluated for pulmonary hypertension were incl... Abstract
Cited 9 times since 2012 (0.7 per year) source: EuropePMC
The American journal of cardiology, Volume 109, Issue 12, 22 4 2012, Pages 1792-1796 Relation of prolonged tissue Doppler imaging-derived atrial conduction time to atrial arrhythmia in adult patients with congenital heart disease. van der Hulst AE, Roest AA, Holman ER, Vliegen HW, Hazekamp MG, Bax JJ, Blom NA, Delgado V
Atrial arrhythmia (AA) is common in adult patients with congenital heart disease (CHD). To enable the prevention of AA or its complications, timely identification of adult patients with CHD at risk of AA is crucial. Long total atrial activation times have been related to AA. Tissue Doppler imaging (TDI) permits noninvasive evaluation of the total atrial conduction time (PA-TDI duration). The present study evaluated the association between the PA-TDI duration and the development of AA in adult pa... Abstract
Cited 16 times since 2012 (1.3 per year) source: EuropePMC
European journal of cardiovascular nursing, Volume 11, Issue 3, 13 2 2012, Pages 349-355 Patients with a congenital heart defect and type D personality feel functionally more impaired, report a poorer health status and quality of life, but use less healthcare. Schoormans D, Mulder BJ, van Melle JP, Pieper EG, van Dijk AP, Sieswerda GJ, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA
Background: Type D personality, characterized by high levels of negative affectivity and social inhibition, is related to mortality, morbidity, poor health status, quality of life (QoL) and less healthcare utilization in various cardiovascular patient groups. To date, studies in patients with congenital heart disease (CHD) are lacking. Aims: (1) To examine the prevalence of type D personality in CHD patients; (2) to compare type D to non-type D patients with regard to disease severity, functiona... Abstract
Cited 29 times since 2012 (2.4 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 3, 3 1 2012, Pages 833-839 Abnormal right atrial and right ventricular diastolic function relate to impaired clinical condition in patients operated for tetralogy of Fallot. Luijnenburg SE, Peters RE, van der Geest RJ, Moelker A, Roos-Hesselink JW, de Rijke YB, Mulder BJ, Vliegen HW, Helbing WA
Background: Atrial enlargement may reflect ventricular diastolic dysfunction. Although patients with tetralogy of Fallot (TOF) have been studied extensively, little is known about atrial size and function. We assessed bi-atrial size and function in patients after TOF repair, and related them to biventricular systolic and diastolic function, and clinical parameters. Methods: 51 Patients (21 ± 8 years) and 30 healthy controls (31 ± 7 years) were included and underwent magnetic resonance imaging to... Abstract
Cited 5 times since 2012 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 3, 25 4 2012, Pages 827-832 Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation. Luijendijk P, Franken RJ, Vriend JW, Zwinderman AH, Vliegen HW, Winter MM, Groenink M, Bouma BJ, Mulder BJ
Aims: Aortic coarctation (CoA) occurs as a "simple" isolated disorder, and in a more "complex" form, combined with associated congenital cardiac abnormalities. Long term outcome of all CoA patients may be complicated by dilatation of the thoracic aorta. The aim of this study was to quantify progressive aortic dilatation, and identify determinants for progressive aortic dilatation. Methods and results: Cardiovascular Magnetic Resonance Imaging (CMR) and echocardiographic data... Abstract
Cited 8 times since 2012 (0.7 per year) source: EuropePMC
Journal of electrocardiology, Volume 45, Issue 3, 20 3 2012, Pages 312-318 Diagnosis and mortality prediction in pulmonary hypertension: the value of the electrocardiogram-derived ventricular gradient. Scherptong RW, Henkens IR, Kapel GF, Swenne CA, van Kralingen KW, Huisman MV, Schuerwegh AJ, Bax JJ, van der Wall EE, Schalij MJ, Vliegen HW
Purpose: The aim of this study was to investigate the use of the electrocardiogram-derived ventricular gradient, projected on the x-axis (VGx), for detection of pulmonary hypertension (PH) and for prediction of all-cause mortality in PH patients. Methods: In patients referred for PH screening (n = 216), the VGx was calculated semiautomatically from the electrocardiogram and was defined as abnormal when less than 24 mV · ms. The VGx of PH patients was compared with the VGx of patients without PH.... Abstract
Cited 4 times since 2011 (0.3 per year) source: EuropePMC
Contemporary clinical trials, Volume 33, Issue 2, 13 2 2011, Pages 410-416 Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Veen G, Zwinderman AH, Mulder BJ
Background: HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established. Methods: We designed a multicentre, prospective, randomised,... Abstract
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 12, 14 2 2011, Pages 1392-1399.e1 Biventricular performance in patients with marfan syndrome without significant valvular disease: comparison to normal subjects and longitudinal follow-up. Scherptong RW, Vliegen HW, van der Wall EE, Hilhorst-Hofstee Y, Bax JJ, Scholte AJ, Delgado V
Background: The presence and progressive nature of primary myocardial involvement in Marfan syndrome are debated. The aim of this study was to evaluate the clinical relevance of left ventricular (LV) and right ventricular (RV) strain in adult patients with Marfan syndrome without significant valvular disease. Methods: Adult patients with Marfan syndrome (n = 50; mean age, 35.2 ± 12.9 years) were followed prospectively. Echocardiography was performed annually and consisted of comprehensive assess... Abstract
Cited 27 times since 2011 (2.1 per year) source: EuropePMC
The American journal of cardiology, Volume 108, Issue 3, 6 1 2011, Pages 435-439 Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood. Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ
Chronic hypertension is a major concern in adults who have undergone resection of coarctation of the aorta (CoA) in childhood. In otherwise healthy subjects, exercise-induced hypertension is prognostic for chronic hypertension; however, the prognostic value in patients with CoA remains unknown. The aim of the present study was to evaluate the predictive value of exercise-induced hypertension for chronic hypertension in these patients. In the present prospective follow-up study, 74 patients with... Abstract
Cited 16 times since 2011 (1.2 per year) source: EuropePMC
Congenital heart disease, Volume 6, Issue 3, 5 1 2011, Pages 219-227 The perspective of patients with congenital heart disease: does health care meet their needs? Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Objective: A first step in the delivery of tailored care is answering the following question: does health care meet the needs of patients? Therefore patients' perspective on health care use and their needs was examined. The design used was cross-sectional questionnaire study. Patients: A total of 1109 adult congenital heart defect (CHD) patients attending one of eight Dutch hospitals were randomly selected from a national database (10% of all registered patients). Main outcome measures: Pat... Abstract
Cited 7 times since 2011 (0.5 per year) source: EuropePMC
Contemporary clinical trials, Volume 32, Issue 4, 17 3 2011, Pages 586-591 Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity? Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ
Background: The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation that a high PVR is a strong predictor of mortality. Long-term follow-up has shown that PVR may rise many years after the Fontan procedure has been performed, possibly due to micro-em... Abstract