Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 2 times since 2015 (0.2 per year) source: EuropePMC
Journal of electrocardiology, Volume 49, Issue 1, 26 4 2015, Pages 60-68 Electrocardiographic detection of pulmonary hypertension in patients with systemic sclerosis using the ventricular gradient. Couperus LE, Vliegen HW, Henkens IR, Maan AC, Treskes RW, de Vries JK, Schouffoer AA, Swenne CA, Schalij MJ, Scherptong RW
Background: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. Methods: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications. The association... Abstract
Cited 9 times since 2015 (1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 101, Issue 21, 14 2 2015, Pages 1717-1723 Individualised prediction of pulmonary homograft durability in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ
Background: In patients with repaired tetralogy of Fallot (rTOF), multiple reoperations or percutaneous interventions after pulmonary valve replacement (PVR) may be necessary due to limited homograft durability. However, data to guide individualised prediction of homograft durability remain scarce. The aim of this study was to provide risk models for RV to pulmonary artery homograft durability. Methods: This retrospective multicentre study included consecutive patients with rTOF who had undergon... Abstract
Cited 15 times since 2015 (1.7 per year) source: EuropePMC
European heart journal, Volume 36, Issue 31, 16 3 2015, Pages 2079-2086 Secundum atrial septal defect is associated with reduced survival in adult men. Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ
Aims: The identification of sex differences in the prognosis of adults with a secundum atrial septal defect (ASD2) could help tailor their clinical management, as it has in other cardiovascular diseases. We investigated whether disparity between the sexes exists in long-term outcome of adult ASD2 patients. Methods and results: Patients with ASD2 classified as the primary defect were selected from the Dutch national registry of adult congenital heart disease. Survival stratified by sex was compar... Abstract
Cited 22 times since 2015 (2.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 101, Issue 10, 31 5 2015, Pages 794-799 Severe tricuspid regurgitation is predictive for adverse events in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ
Objective: Patients with surgically repaired tetralogy of Fallot (rTOF) may develop functional tricuspid regurgitation (TR) due to annulus dilation. Guidelines suggest pulmonary valve replacement (PVR) in patients with rTOF with progressive TR, but data on clinical outcomes are lacking. Our objective was to determine whether TR was predictive for adverse events after PVR. Methods: In this retrospective, multicenter cohort study, patients with rTOF who had undergone PVR after preoperative echocar... Abstract
Cited 7 times since 2015 (0.8 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 48, Issue 5, 1 1 2015, Pages 724-30; discussion 730-1 Surgical treatment of aberrant aortic origin of coronary arteries. Kooij M, Vliegen HW, de Graaf MA, Hazekamp MG
Objectives: Aberrant origin of the coronary arteries is rare but can be life threatening. It is an important cause of sudden death in athletes and other young adults, and may be treated surgically. Consensus exists that interarterial left coronary artery (LCA) should be surgically repaired. For interarterial right coronary artery (RCA), the discussion remains open. The purpose of this study was to analyse our surgical experience. Methods: From 2001 until 2014, 31 patients were operated for inter... Abstract
Cited 11 times since 2014 (1.2 per year) source: EuropePMC
European journal of cardiovascular nursing, Volume 15, Issue 1, 20 3 2014, Pages 72-81 Clinical and psychological characteristics predict future healthcare use in adults with congenital heart disease. Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Background: To deliver adequate care to patients with congenital heart disease (CHD), it is important to know which patients use what type of care. This knowledge is valuable, as modification of these factors may be used as means to regulate healthcare use. Our objective was to examine the predictive value of psychological characteristics for future healthcare use, independent of clinical characteristics. Methods: In total 845 adult CHD-patients participated in a longitudinal questionnaire study... Abstract
Cited 14 times since 2014 (1.4 per year) source: EuropePMC
International journal of cardiology, Volume 176, Issue 3, 17 3 2014, Pages 776-781 Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ
Background: Adult post-coarctectomy patients (CoA) demonstrate increased cardiovascular morbidity and mortality. The carotid intima-media thickness (CIMT), a marker for atherosclerosis, is increased in CoA. The aim was to evaluate the predictive value of CIMT for cardiovascular events. Methods and results: Consecutive CoA patients were prospectively studied during 10.1±0.7 years follow-up. At baseline and follow-up echocardiography, MRI imaging and CIMT imaging were performed, while cardiovascul... Abstract
Cited 69 times since 2014 (7.1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 100, Issue 17, 17 3 2014, Pages 1373-1381 Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG, ZAHARA-II investigators
Objectives: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPR... Abstract
Cited 8 times since 2014 (0.8 per year) source: EuropePMC
International journal of cardiology, Volume 176, Issue 1, 28 4 2014, Pages 40-47 Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation? Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ
Background: Carotid intima-media thickness (CIMT) is a marker for atherosclerosis. Adult post-coarctectomy patients (CoA) demonstrate an increased cardiovascular risk and increased CIMT compared to controls. This study evaluates the effect of high dose statins on the change in CIMT and cardiovascular risk. Methods: We designed a multicenter, prospective, randomized, open label trial with blinded endpoint (PROBE design) to evaluate the effect of three year treatment with atorvastatin 80 mg on CIM... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 101, Issue 4, 22 4 2014, Pages 311-319 Diagnosis and treatment of pulmonary hypertension. Haeck ML, Vliegen HW
Cited 12 times since 2014 (1.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 100, Issue 17, 16 3 2014, Pages 1360-1365 Persistent neo-aortic growth during adulthood in patients after an arterial switch operation. van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ
Objective: After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods: All 116 ASO patients operated in a tertiary referral centre and born before 1995 were... Abstract
Cited 11 times since 2014 (1.1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 30, Issue 4, 4 1 2014, Pages 713-720 Impact of right ventricular dyssynchrony on left ventricular performance in patients with pulmonary hypertension. Haeck ML, Höke U, Marsan NA, Holman ER, Wolterbeek R, Bax JJ, Schalij MJ, Vliegen HW, Delgado V
Pulmonary hypertension has been associated with right ventricular (RV) dyssynchrony which may induce left ventricular (LV) dysfunction and dyssynchrony through ventricular interdependence. The present study evaluated the influence of RV dyssynchrony on LV performance in patients with pulmonary hypertension. One hundred and seven patients with pulmonary hypertension (age 63 ± 14 years, systolic pulmonary arterial pressure 60 ± 19 mmHg) and LV ejection fraction (EF) >35% were evaluated. Ventric... Abstract
Cited 14 times since 2013 (1.3 per year) source: EuropePMC
Journal of electrocardiology, Volume 47, Issue 2, 1 1 2013, Pages 175-182 Electrocardiographic detection of right ventricular pressure overload in patients with suspected pulmonary hypertension. Kamphuis VP, Haeck ML, Wagner GS, Maan AC, Maynard C, Delgado V, Vliegen HW, Swenne CA
Background and purpose: Early, preferably noninvasive, detection of pulmonary hypertension improves prognosis. Our study evaluated the diagnostic accuracy of the electrocardiographically derived Butler-Leggett (BL) score and ventricular gradient (VG) to estimate mean pulmonary artery pressure (PAP). Methods: In 63 patients with suspected pulmonary hypertension, BL score and VG were calculated. The VG was projected on a direction optimized for detection of right ventricular pressure overload (VG-... Abstract
Cited 18 times since 2013 (1.7 per year) source: EuropePMC
International journal of cardiology, Volume 169, Issue 6, 11 2 2013, Pages 439-444 5-year serial follow-up of clinical condition and ventricular function in patients after repair of tetralogy of Fallot. Luijnenburg SE, Helbing WA, Moelker A, Kroft LJ, Groenink M, Roos-Hesselink JW, de Rijke YB, Hazekamp MG, Bogers AJ, Vliegen HW, Mulder BJ
Objective: To study the changes over time in biventricular size and function, and clinical parameters in patients after repair of tetralogy of Fallot (TOF) without subsequent pulmonary valve replacement (PVR). Methods: We prospectively included 78 non-PVR patients (age 20(6-60)years at baseline), who were studied twice with a 5-year interval. Patients underwent magnetic resonance imaging for assessment of biventricular size and function. Exercise testing and electrocardiography were performed to... Abstract
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 15, Issue 2, 18 3 2013, Pages 189-194 Ventricular response to dobutamine stress relates to the change in peak oxygen uptake during the 5-year follow-up in young patients with repaired tetralogy of Fallot. Luijnenburg SE, Mekic S, van den Berg J, van der Geest RJ, Moelker A, Roos-Hesselink JW, Bogers AJ, de Rijke YB, Strengers JL, Mulder BJ, Vliegen HW, Helbing WA
Aims: To evaluate the additional value of dobutamine stress testing in patients with repaired tetralogy of Fallot (TOF) by relating stress imaging parameters at baseline to relevant parameters of clinical condition and right ventricular (RV) size during a serial follow-up. Methods and results: We prospectively included 27 patients (14 ± 4 years at baseline), who were studied twice with a 5-year interval. Patients underwent cardiovascular magnetic resonance imaging to assess RV systolic and diast... Abstract
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 96, Issue 4, 16 3 2013, Pages 1390-1397 Variation in coronary anatomy in adult patients late after arterial switch operation: a computed tomography coronary angiography study. Veltman CE, Beeres SLMA, Kalkman DN, Kelder TP, Kiès P, Vliegen HW, Hazekamp MG, Delgado V, Kroft LJM, van der Wall EE, Gittenberger-de Groot AC, Scholte AJHA, Schalij MJ, Jongbloed MRM
Background: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. Methods: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal c... Abstract
Cited 5 times since 2013 (0.5 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 12, 12 2 2013, Pages 1757-1762 Atrial-based pacing has no benefit over ventricular pacing in preventing atrial arrhythmias in adults with congenital heart disease. Opic P, Yap SC, Van Kranenburg M, Van Dijk AP, Budts W, Vliegen HW, Van Erven L, Can A, Sahin G, De Groot NM, Witsenburg M, Roos-Hesselink JW
Aims: To determine whether atrial-based pacing prevents atrial arrhythmias in adults with congenital heart disease (CHD) compared with ventricular pacing. Methods and results: All adult CHD patients from four participating centres with a permanent pacemaker were identified. Patients with permanent atrial arrhythmias at pacemaker implantation and patients who received a pacemaker for treatment of drug-refractory atrial arrhythmias were excluded. The final study population consisted of 211 patient... Abstract
Cited 24 times since 2013 (2.2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 62, Issue 10, 10 2 2013, Pages 926-936 Right ventricular end-diastolic volume combined with peak systolic blood pressure during exercise identifies patients at risk for complications in adults with a systemic right ventricle. van der Bom T, Winter MM, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ
Objectives: The aim of this study was to identify which patients with a systemic right ventricle are at risk for clinical events. Background: In patients with congenitally or atrially corrected transposition of the great arteries, worsening of the systemic right ventricle is accompanied by clinical events such as clinical heart failure or the occurrence of arrhythmia. Methods: At baseline, all subjects underwent electrocardiography, echocardiography, cardiopulmonary exercise testing, and cardiov... Abstract
Cited 8 times since 2013 (0.7 per year) source: EuropePMC
International journal of cardiology, Volume 168, Issue 4, 3 1 2013, Pages 3212-3216 Complications of pacemaker therapy in adults with congenital heart disease: a multicenter study. Opić P, van Kranenburg M, Yap SC, van Dijk AP, Budts W, Vliegen HW, van Erven L, Can A, Sahin G, Theuns DA, Witsenburg M, Roos-Hesselink JW
Background: This study aims to investigate indications and complications of permanent cardiac pacing in adults with congenital heart disease (CHD). Methods and results: Two-hundred and seventy-four CHD patients were identified who underwent permanent pacemaker implantation between 1972 and 2009. The indication for pacing was acquired sinus node or AV node conduction disease (63%), sinus node or AV node conduction disease after cardiac surgery (28%), and drug/arrhythmia-related indications (9%).... Abstract
Cited 36 times since 2013 (3.2 per year) source: EuropePMC
European journal of cardiovascular nursing, Volume 13, Issue 1, 22 4 2013, Pages 86-94 Illness perceptions of adults with congenital heart disease and their predictive value for quality of life two years later. Schoormans D, Mulder BJ, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA
Background: To improve patients' quality of life (QoL) we need to identify modifiable determinants, such as illness perceptions. Patients' illness perceptions are known to regulate emotional responses and health-behaviour. Illness perceptions comprise several components: consequences, control, coherence, changeability and emotional representations. Aims: To examine (a) the relation between patient characteristics and illness perceptions, and (b) the independent predictive value of illn... Abstract