Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Cited 24 times since 2009 (1.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 3, 28 4 2009, Pages 213-219 Single-beat estimation of the left ventricular end-diastolic pressure-volume relationship in patients with heart failure. Ten Brinke EA, Burkhoff D, Klautz RJ, Tschöpe C, Schalij MJ, Bax JJ, van der Wall EE, Dion RA, Steendijk P
Aims: To test a method to predict the end-diastolic pressure-volume relationship (EDPVR) from a single beat in patients with heart failure. Methods and results: Patients (New York Heart Association class III-IV) scheduled for mitral annuloplasty (n=9) or ventricular restoration (n=10) and patients with normal left ventricular function undergoing coronary artery bypass grafting (n=12) were instrumented with pressure-conductance catheters to measure pressure-volume loops before and after surgery.... Abstract
Cited 11 times since 2009 (0.8 per year) source: EuropePMC
Acta anaesthesiologica Scandinavica, Volume 54, Issue 4, 15 3 2009, Pages 470-478 Xenon and isoflurane improved biventricular function during right ventricular ischemia and reperfusion. Hein M, Roehl AB, Baumert JH, Bleilevens C, Fischer S, Steendijk P, Rossaint R
Background: Although anesthetics have some cardioprotective properties, these benefits are often counterbalanced by their negative inotropic effects. Xenon, on the other hand, does not influence myocardial contractility. Thus, xenon may be a superior treatment for the maintenance of global hemodynamics, especially during right ventricular ischemia, which is generally characterized by a high acute complication rate. Methods: The effects of 70 vol% xenon and 0.9 vol% isoflurane on biventricular fu... Abstract
Cited 19 times since 2009 (1.3 per year) source: EuropePMC
Circulation, Volume 120, Issue 17, 12 2 2009, Pages 1687-1694 Short-term hemodynamic effects of cardiac resynchronization therapy in patients with heart failure, a narrow QRS duration, and no dyssynchrony. Williams LK, Ellery S, Patel K, Leyva F, Bleasdale RA, Phan TT, Stegemann B, Paul V, Steendijk P, Frenneaux M
Background: Cardiac resynchronization therapy produces both short-term hemodynamic and long-term symptomatic/mortality benefits in symptomatic heart failure patients with a QRS duration >120 ms. This is conventionally believed to be due principally to relief of dyssynchrony, although we recently showed that relief of external constraint to left ventricular filling may also play a role. In this study, we evaluated the short-term hemodynamic effects in symptomatic patients with a QRS duration Abstract
The Journal of thoracic and cardiovascular surgery, Volume 140, Issue 1, 26 4 2009, Pages 240-241 Balloon sizing in surgical ventricular restoration: what volume are we targeting? ten Brinke EA, Klautz RJ, Steendijk P
Cited 68 times since 2009 (4.7 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 297, Issue 5, 25 4 2009, Pages H1606-16 Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension. Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani el H, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A
Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular (RV) hypertrophy (RVH), remodeling, and failure. We tested treatment with bone marrow-derived mesenchymal stem cells (MSCs) obtained from donor rats with monocrotaline (MCT)-induced PAH to recipient rats with MCT-induced PAH on pulmonary artery pressure, lung pathology, and RV function. This model was chosen to mimic autologous MSC therapy. On day 1, PAH was induced by MCT (60 mg/kg) in 20 female Wist... Abstract
Cited 24 times since 2009 (1.6 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 198, Issue 1, 6 1 2009, Pages 37-46 Single-beat estimation of the left ventricular end-systolic pressure-volume relationship in patients with heart failure. ten Brinke EA, Klautz RJ, Verwey HF, van der Wall EE, Dion RA, Steendijk P
Aim: The end-systolic pressure-volume relationship (ESPVR) constructed from multiple pressure-volume (PV) loops acquired during load intervention is an established method to asses left ventricular (LV) contractility. We tested the accuracy of simplified single-beat (SB) ESPVR estimation in patients with severe heart failure. Methods: Nineteen heart failure patients (NYHA III-IV) scheduled for surgical ventricular restoration and/or restrictive mitral annuloplasty and 12 patients with normal LV f... Abstract
Cited 141 times since 2009 (9.7 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 30, Issue 3, 1 1 2009, Pages 521-526 Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI. Grotenhuis HB, Westenberg JJ, Steendijk P, van der Geest RJ, Ottenkamp J, Bax JJ, Jukema JW, de Roos A
Purpose: To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI. Materials and methods: PWV(MRI) was compared with PWV(INV) in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV(MRI) was tested in 10 healthy volunteers who underwent repeated measuremen... Abstract
Cited 18 times since 2009 (1.2 per year) source: EuropePMC
International journal of cardiology, Volume 147, Issue 1, 28 4 2009, Pages 52-57 Can we use the end systolic volume index to monitor intrinsic right ventricular function after repair of tetralogy of Fallot? Uebing A, Fischer G, Schlangen J, Apitz C, Steendijk P, Kramer HH
Background: After tetralogy of Fallot (ToF) repair the right ventricle (RV) is commonly exposed to abnormal volume load resulting from pulmonary regurgitation (PR) leading to progressive RV dilatation. The objective of this study was to assess the relationship between RV volumes, especially the end systolic volume index (ESVi), and RV contractility in patients after ToF repair and significant PR and to determine whether RV dilatation reflects intrinsic RV dysfunction in these patients. Methods:... Abstract
Cited 17 times since 2009 (1.2 per year) source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Volume 24, Issue 3-4, 3 1 2009, Pages 201-210 Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels. Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A
Background: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. Methods: Rats were treated with MCT in low dose (30 mg/kg, MCT30, n=10) to induce compensated RV hypertrophy, in high dose (80 mg/kg, MCT80, n=11) to... Abstract
Critical care medicine, Volume 37, Issue 8, 1 1 2009, Pages 2482-2483 Optimizing the shape of defibrillation shocks. Steendijk P
Cited 172 times since 2009 (11.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 54, Issue 5, 1 1 2009, Pages 402-409 Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. Phan TT, Abozguia K, Nallur Shivu G, Mahadevan G, Ahmed I, Williams L, Dwivedi G, Patel K, Steendijk P, Ashrafian H, Henning A, Frenneaux M
Objectives: We sought to evaluate the role of exercise-related changes in left ventricular (LV) relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and to assess myocardial energetic status in these patients. Background: To date, no studies have investigated exercise-related changes in LV relaxation and VVC as well as in vivo myocardial energetic status in patients with HFpEF. Methods: We... Abstract
Cited 22 times since 2009 (1.5 per year) source: EuropePMC
Pediatric research, Volume 66, Issue 1, 1 1 2009, Pages 74-79 Histopathological changes of the heart after neonatal dexamethasone treatment: studies in 4-, 8-, and 50-week-old rats. Bal MP, de Vries WB, Steendijk P, Homoet-van der Kraak P, van der Leij FR, Baan J, van Oosterhout MF, van Bel F
Dexamethasone (Dex), for prevention of chronic lung disease in preterm infants, showed potential negative long-term effects. Studies regarding long-term cardiovascular effects are lacking. We investigated possible histopathological myocardial changes after neonatal Dex in the young and adult rat heart. Rats were treated with Dex on d 1, 2, and 3 (0.5, 0.3, and 0.1 mg/kg) of life. Control-pups received saline. At 4, 8, and 50 wk after birth rats were killed and anatomic data collected. Heart tiss... Abstract
Cited 11 times since 2009 (0.7 per year) source: EuropePMC
Annals of biomedical engineering, Volume 37, Issue 9, 25 4 2009, Pages 1710-1726 Modeling the instantaneous pressure-volume relation of the left ventricle: a comparison of six models. Lankhaar JW, Rövekamp FA, Steendijk P, Faes TJ, Westerhof BE, Kind T, Vonk-Noordegraaf A, Westerhof N
Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted to the PV-data measured in five sheep and the estimated parameters were used to simulate PV-loops. Simulated and measured PV-loops were compared with the Akaike information crit... Abstract
Cited 17 times since 2009 (1.1 per year) source: EuropePMC
Comparative medicine, Volume 59, Issue 3, 1 1 2009, Pages 280-286 Comparison of 3 methods to induce acute pulmonary hypertension in pigs. Roehl AB, Steendijk P, Baumert JH, Schnoor J, Rossaint R, Hein M
Large animal models for acute pulmonary hypertension (PHT) show distinct differences between species and underlying mechanisms. Two embolic procedures and continuous infusion of a stable thromboxane A(2) analogue (U46619) were explored for their ability to induce PHT and their effects on right ventricular function and pulmonary and systemic circulation in 9 pigs. Injection of small (100 to 200 microm) or large (355 to 425 microm) polystyrene beads and incremental dosage (0.2 to 0.8 microg kg(-1)... Abstract
Cited 21 times since 2009 (1.4 per year) source: EuropePMC
Acta anaesthesiologica Scandinavica, Volume 53, Issue 7, 6 1 2009, Pages 941-948 Anti-ischemic effects of inotropic agents in experimental right ventricular infarction. Hein M, Roehl AB, Baumert JH, Scherer K, Steendijk P, Rossaint R
Background: Right ventricular (RV) function is an important determinant of survival after myocardial infarction. The efficacy of reperfusion therapy might be increased by the cardioprotective action of inotropic agents, which are used for symptomatic therapy in situations with compromised hemodynamics. Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of milrinone, levosimendan and dobutamine on the extent and degree of myocardial injury. Method... Abstract
Cited 2 times since 2009 (0.1 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 196, Issue 4, 19 3 2009, Pages 375-383 Left ventricular mechanical dyssynchrony is load independent at rest and during endotoxaemia in a porcine model. A'roch R, Steendijk P, Oldner A, Weitzberg E, Konrad D, Johansson G, Haney M
Aim: In diseased or injured states, the left ventricle displays higher degrees of mechanical dyssynchrony. We aimed at assessing mechanical dyssynchrony ranges in health related to variation in load as well as during acute endotoxin-induced ventricular injury. Methods: In 16 juvenile anaesthetized pigs, a five-segment conductance catheter was placed in the left ventricle as well as a balloon-tipped catheter in the inferior vena cava. Mechanical dyssynchrony during systole, including dyssynchrony... Abstract
Critical care medicine, Volume 37, Issue 3, 1 1 2009, Pages 1130-1131 The fate and role of mesenchymal stem cells engrafted in the heart after a myocardial infarction during a second ischemic event. Steendijk P
Cited 7 times since 2009 (0.5 per year) source: EuropePMC
European journal of anaesthesiology, Volume 26, Issue 3, 1 1 2009, Pages 253-259 Impact of calcium-channel blockers on right heart function in a controlled model of chronic pulmonary hypertension. Zierer A, Voeller RK, Melby SJ, Steendijk P, Moon MR
Background and objective: Patients with chronic pulmonary hypertension (CPH) who demonstrate pulmonary vasodilation following calcium-channel blocker (CCB) administration are defined as 'responders'. In contrast, 'nonresponders' are patients who do not show such pulmonary vasodilation with CCB therapy. The purpose of this investigation was to study the effects of CCB therapy on right heart mechanics in experimental CCB responders versus CCB nonresponders. Methods: In 12 dogs,... Abstract
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Neonatology, Volume 96, Issue 2, 19 3 2009, Pages 86-92 Inverse relationship between birth weight and blood pressure in growth-retarded but not in appropriate for gestational age infants during the first week of life. Smal JC, Uiterwaal CS, Bruinse HW, Steendijk P, van Bel F
Background: Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. Objective: To study the relationship between birth weight and blood pressure during the first week of life. Methods: Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MBP) were measured every 8 h... Abstract
Cited 15 times since 2009 (1 per year) source: EuropePMC
European heart journal, Volume 30, Issue 7, 7 1 2009, Pages 797-804 Pressure-volume loop analysis during implantation of biventricular pacemaker/cardiac resynchronization therapy device to optimize right and left ventricular pacing sites. Delnoy PP, Ottervanger JP, Luttikhuis HO, Vos DH, Elvan A, Ramdat Misier AR, Beukema WP, Steendijk P, van Hemel NM
Aims: To evaluate the clinical utility of pressure-volume loop analyses during pacemaker/implantable cardioverter defibrillator (ICD) implantations to assess the optimal right ventricular (RV) and/or left ventricular (LV) lead position. Methods and results: 29 patients with heart failure and chronic RV apical pacing were studied. Stroke work (SW), LV ejection fraction (LVEF), cardiac output (CO), and LV dP/dt(max) were assessed using a conductance catheter in the LV during RV apical, RV outflow... Abstract