Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Cited 346 times since 2010 (25.7 per year) source: EuropePMC
Circulation. Heart failure, Volume 4, Issue 1, 12 2 2010, Pages 44-52 Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Westermann D, Lindner D, Kasner M, Zietsch C, Savvatis K, Escher F, von Schlippenbach J, Skurk C, Steendijk P, Riad A, Poller W, Schultheiss HP, Tschöpe C
Background: The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. Methods and results: We investigated left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter methods and echocardiography. Endomyocardial biopsy samples were also obtained, and ECM proteins as well as c... Abstract
Cited 38 times since 2010 (2.8 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 32, Issue 5, 1 1 2010, Pages 1086-1094 Improved aortic pulse wave velocity assessment from multislice two-directional in-plane velocity-encoded magnetic resonance imaging. Westenberg JJ, de Roos A, Grotenhuis HB, Steendijk P, Hendriksen D, van den Boogaard PJ, van der Geest RJ, Bax JJ, Jukema JW, Reiber JH
Purpose: To evaluate the accuracy and reproducibility of aortic pulse wave velocity (PWV) assessment by in-plane velocity-encoded magnetic resonance imaging (MRI). Materials and methods: In 14 patients selected for cardiac catheterization on suspicion of coronary artery disease and 15 healthy volunteers, PWV was assessed with multislice two-directional in-plane velocity-encoded MRI (PWV(i.p.)) and compared with conventionally assessed PWV from multisite one-directional through-plane velocity-enc... Abstract
Cited 17 times since 2010 (1.2 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 299, Issue 6, 17 3 2010, Pages H2037-45 The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction. Bongartz LG, Braam B, Verhaar MC, Cramer MJ, Goldschmeding R, Gaillard CA, Steendijk P, Doevendans PA, Joles JA
We recently developed a rat model of cardiorenal failure that is characterized by severe left ventricular systolic dysfunction (LVSD) and low nitric oxide (NO) production that persisted after temporary low-dose NO synthase inhibition. We hypothesized that LVSD was due to continued low NO availability and might be reversed by supplementing NO. Rats underwent a subtotal nephrectomy and were treated with low-dose NO synthase inhibition with N(ω)-nitro-l-arginine up to week 8. After 3 wk of washout,... Abstract
Cited 38 times since 2010 (2.8 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 5, 14 2 2010, Pages 623-631 Pulmonary vascular resistance, collateral flow, and ventricular function in patients with a Fontan circulation at rest and during dobutamine stress. Schmitt B, Steendijk P, Ovroutski S, Lunze K, Rahmanzadeh P, Maarouf N, Ewert P, Berger F, Kuehne T
Background: The role, interplay, and relative importance of the multifactorial hemodynamic and myocardial mechanisms causing dysfunction of the Fontan circulation remain incompletely understood. Methods and results: Using an MRI catheterization technique, we performed a differential analysis of pulmonary vascular resistance and aortopulmonary collateral blood flow in conjunction with global ventricular pump function, myocontractility (end-systolic pressure-volume relation), and diastolic complia... Abstract
Cited 36 times since 2010 (2.6 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 299, Issue 2, 21 3 2010, Pages H364-71 Integrated analysis of atrioventricular interactions in tetralogy of Fallot. Riesenkampff E, Mengelkamp L, Mueller M, Kropf S, Abdul-Khaliq H, Sarikouch S, Beerbaum P, Hetzer R, Steendijk P, Berger F, Kuehne T
The atria play an important role in cardiac performance. We evaluated their function and the atrioventricular interaction in operated patients with tetralogy of Fallot (TOF). Twenty patients who had undergone surgical repair of TOF and seven controls were investigated. Patients had residual pulmonary but no major tricuspid valve insufficiency. Atrial and ventricular strain rates were obtained by echocardiographic speckle tracking. Cine MRI-derived volumetric analysis provided atrial and ventricu... Abstract
Cited 60 times since 2010 (4.3 per year) source: EuropePMC
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 11, Issue 9, 19 3 2010, Pages 743-751 Global strain rate imaging for the estimation of diastolic function in HFNEF compared with pressure-volume loop analysis. Kasner M, Gaub R, Sinning D, Westermann D, Steendijk P, Hoffmann W, Schultheiss HP, Tschöpe C
Aims: Strain rate imaging provides direct information on intrinsic myocardial function and may improve the diagnostic of diastolic dysfunction in heart failure with normal ejection fraction (HFNEF). We therefore correlated global strain with pressure-volume (PV) loop analysis and compared it with flow and tissue Doppler measurements. Methods and results: Longitudinal two-dimensional strain rate and flow and tissue Doppler (TDI) indices were measured simultaneously and correlated with diastolic i... Abstract
The international journal of cardiovascular imaging, Volume 27, Issue 7, 17 3 2010, Pages 943-945 Evaluation of pulmonary arterial hypertension: invasive or noninvasive? van der Laarse A, Steendijk P, van der Wall EE
Cited 15 times since 2010 (1.1 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 140, Issue 6, 9 2 2010, Pages 1338-1344 Long-term effects of surgical ventricular restoration with additional restrictive mitral annuloplasty and/or coronary artery bypass grafting on left ventricular function: six-month follow-up by pressure-volume loops. ten Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Schalij MJ, van der Wall EE, Versteegh MI, Dion RA, Steendijk P
Objectives: Previous studies demonstrated beneficial short-term effects of surgical ventricular restoration on mechanical dyssynchrony and left ventricular function and improved midterm and long-term clinical parameters. However, long-term effects on systolic and diastolic left ventricular function are still largely unknown. Methods: We studied 9 patients with ischemic dilated cardiomyopathy who underwent surgical ventricular restoration with additional restrictive mitral annuloplasty and/or cor... Abstract
Cited 6 times since 2010 (0.4 per year) source: EuropePMC
Circulation, Volume 121, Issue 13, 1 1 2010, Pages e261-2 Images in cardiovascular medicine. Direct endoscopic visual assessment of a transcatheter aortic valve implantation and performance in the Physioheart, an isolated working heart platform. de Weger A, van Tuijl S, Stijnen M, Steendijk P, de Hart J
Cited 14 times since 2010 (1 per year) source: EuropePMC
Journal of biomedicine & biotechnology, Volume 2010, 22 4 2010, Pages 702836 Novel approaches to treat experimental pulmonary arterial hypertension: a review. Umar S, Steendijk P, Ypey DL, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A
Background: Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by an increase in pulmonary artery pressure leading to right ventricular (RV) hypertrophy, RV failure, and ultimately death. Current treatments can improve symptoms and reduce severity of the hemodynamic disorder but gradual deterioration in their condition often necessitates a lung transplant. Methods and results: In experimental models of PAH, particularly the model of monocrotaline-induced pulmonary... Abstract
The international journal of cardiovascular imaging, Volume 26, Issue 2, 1 1 2010, Pages 161-164 Cardiovascular dynamics in ischemic cardiomyopathy during exercise. van der Wall EE, Bax JJ, Swenne CA, Steendijk P, Schalij MJ
Cited 9 times since 2010 (0.6 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 140, Issue 4, 1 1 2010, Pages 807-815 Noninvasive estimation of left ventricular filling pressures in patients with heart failure after surgical ventricular restoration and restrictive mitral annuloplasty. ten Brinke EA, Bertini M, Klautz RJ, Antoni ML, Holman ER, van de Veire NR, Bax JJ, Steendijk P
Objective: Doppler echocardiography, including tissue Doppler imaging, is widely applied to assess diastolic left ventricular function using early transmitral flow velocity combined with mitral annular velocity as a noninvasive estimate of left ventricular filling pressures. However, the accuracy of early transmitral flow velocity/mitral annular velocity in patients with heart failure, particularly after extensive cardiac surgery, is debated. Global diastolic strain rate during isovolumic relaxa... Abstract
Critical care medicine, Volume 38, Issue 2, 1 1 2010, Pages 725-727 Toward therapeutic use of hydrogen sulfide in critical care? Steendijk P
Cited 38 times since 2010 (2.7 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 199, Issue 1, 22 4 2010, Pages 43-52 Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction. Post H, Schmitto JD, Steendijk P, Christoph J, Holland R, Wachter R, Schöndube FW, Pieske B
Aim: The induction of mild hypothermia (MH; 33 degrees C) has become the guideline therapy to attenuate hypoxic brain injury after out-of-hospital cardiopulmonary resuscitation. While MH exerts a positive inotropic effect in vitro, MH reduces cardiac output in vivo and is thus discussed critically when severe cardiac dysfunction is present in patients. We thus assessed the effect of MH on the function of the normal heart in an in vivo model closely mimicking the clinical setting. Methods: Ten an... Abstract
Cited 12 times since 2010 (0.8 per year) source: EuropePMC
International journal of cardiology, Volume 149, Issue 1, 6 1 2010, Pages 23-29 Simultaneous estimation of NT-proBNP on top to mitral flow Doppler echocardiography as an accurate strategy to diagnose diastolic dysfunction in HFNEF. Kasner M, Gaub R, Westermann D, Kaplan H, Akpulat S, Steendijk P, Schultheiss HP, Tschöpe C
Background: Conventional echocardiography has limited accuracy in detecting diastolic dysfunction and NT-proBNP is known to be a reliable biomarker to rule out heart failure. Therefore NT-proBNP on top to conventional mitral flow Doppler might improve the diagnostic of diastolic dysfunction in patients with heart failure despite normal EF (HFNEF) without using tissue Doppler. Methods and results: Diastolic function of 46 patients with HFNEF was determined by pressure-volume loop obtained by cond... Abstract
Cited 1 times since 2010 (0.1 per year) source: EuropePMC
Innovations (Philadelphia, Pa.), Volume 5, Issue 1, 1 1 2010, Pages 16-21 Resizable ventricular patch plasty in the porcine left ventricle: a pilot study. Huijgen WH, Gründeman PF, van der Spoel T, Cramer MJ, Steendijk P, Klautz RJ, van Herwerden LA
Objective: : Endoventricular circular patch plasty is a method used to reconstruct the ventricular cavity in patients with (post) ischemic left ventricular aneurysm or global dilatation. However, late redilatation with mitral regurgitation has been reported, in which postoperative apex shape seems to play an important role. We studied the feasibility of ventricular volume downsizing with a variably shaped patch in porcine hearts. Methods: : In five in vitro and two acute animal experiments, a dy... Abstract
Cited 68 times since 2009 (4.7 per year) source: EuropePMC
European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3027-3036 Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Wachter R, Schmidt-Schweda S, Westermann D, Post H, Edelmann F, Kasner M, Lüers C, Steendijk P, Hasenfuss G, Tschöpe C, Pieske B
Aims: We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing heart rates, and this contributes to impaired frequency-dependent augmentation of cardiac output. Methods and results: In 17 patients with HFNEF (median age 69 years, 13 female) and seven age-matched control patients, systolic and diastolic function was analysed by pressure-volume loops at baseline heart rate and during atrial pacing to 100 and 120 min(-... Abstract
Cited 147 times since 2009 (10.2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 55, Issue 6, 20 3 2009, Pages 566-575 Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites: the lateral left ventricular wall and the coronary sinus are rarely the best sites. Derval N, Steendijk P, Gula LJ, Deplagne A, Laborderie J, Sacher F, Knecht S, Wright M, Nault I, Ploux S, Ritter P, Bordachar P, Lafitte S, Réant P, Klein GJ, Narayan SM, Garrigue S, Hocini M, Haissaguerre M, Clementy J, Jaïs P
Objectives: We sought to evaluate the impact of the left ventricular (LV) pacing site on hemodynamic response to cardiac resynchronization therapy (CRT). Background: CRT reduces morbidity and mortality in heart failure patients. However, 20% to 40% of eligible patients may not fully benefit from CRT device implantation. We hypothesized that selecting the optimal LV pacing site could be critical in this issue. Methods: Thirty-five patients with nonischemic dilated cardiomyopathy referred for CRT... Abstract
Cited 31 times since 2009 (2.1 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 11, 1 1 2009, Pages 1271-1281 Integrated assessment of diastolic and systolic ventricular function using diagnostic cardiac magnetic resonance catheterization: validation in pigs and application in a clinical pilot study. Schmitt B, Steendijk P, Lunze K, Ovroutski S, Falkenberg J, Rahmanzadeh P, Maarouf N, Ewert P, Berger F, Kuehne T
Objectives: This study sought to develop and validate a method for the integrated analysis of systolic and diastolic ventricular function. Background: An integrated approach to assess ventricular pump function, myocontractility (end-systolic pressure-volume relationship [ESPVR]), and diastolic compliance (end-diastolic pressure-volume relation [EDPVR]) is of high clinical value. Cardiac magnetic resonance (CMR) is well established for measuring global pump function, and catheterization-combined... Abstract
Cited 7 times since 2009 (0.5 per year) source: EuropePMC
Critical care medicine, Volume 37, Issue 11, 1 1 2009, Pages 2962-2967 Continuous right ventricular volumetry by fast-response thermodilution during right ventricular ischemia: head-to-head comparison with conductance catheter measurements. Hein M, Roehl AB, Baumert JH, Rossaint R, Steendijk P
Objective: To evaluate the accuracy of right ventricular ejection fraction and right ventricular end-diastolic volume obtained by volumetric pulmonary artery catheter, using the conductance catheter as reference method. Design: Prospective, comparative study. Setting: Research laboratory of a university hospital. Subjects: Seven young female German landrace pigs. Interventions: Ligation of the distal right coronary artery to induce temporary acute ischemia. Measurements and main results: Right v... Abstract