Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Cited 14 times since 2013 (1.2 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 304, Issue 4, 4 1 2013, Pages L264-75 Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury. Wagenaar GT, Laghmani el H, de Visser YP, Sengers RM, Steendijk P, Baelde HJ, Walther FJ
Ambrisentan, an endothelin receptor type A antagonist, may be a novel therapeutic agent in neonatal chronic lung disease (CLD) by blocking the adverse effects of the vasoconstrictor endothelin-1, especially pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). We determined the cardiopulmonary effects of ambrisentan treatment (1-20 mg·kg(-1)·day(-1)) in neonatal rats with CLD in 2 models: early treatment during continuous exposure to hyperoxia for 10 days and late tr... Abstract
Cited 88 times since 2012 (7.5 per year) source: EuropePMC
European heart journal, Volume 34, Issue 36, 24 4 2012, Pages 2839-2849 Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. Reil JC, Hohl M, Reil GH, Granzier HL, Kratz MT, Kazakov A, Fries P, Müller A, Lenski M, Custodis F, Gräber S, Fröhlig G, Steendijk P, Neuberger HR, Böhm M
Aims: In diabetes mellitus, heart failure with preserved ejection fraction (HFPEF) is a significant comorbidity. No therapy is available that improves cardiovascular outcomes. The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model. Methods and results: Control mice, diabetic mice (db/db), and db/db mice treated for 4 weeks wit... Abstract
Cited 26 times since 2012 (2.2 per year) source: EuropePMC
Journal of cellular and molecular medicine, Volume 16, Issue 7, 1 1 2012, Pages 1508-1521 Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts. den Haan MC, Grauss RW, Smits AM, Winter EM, van Tuyn J, Pijnappels DA, Steendijk P, Gittenberger-De Groot AC, van der Laarse A, Fibbe WE, de Vries AA, Schalij MJ, Doevendans PA, Goumans MJ, Atsma DE
We previously showed that human cardiomyocyte progenitor cells (hCMPCs) injected after myocardial infarction (MI) had differentiated into cardiomyocytes in vivo 3 months after MI. Here, we investigated the short-term (2 weeks) effects of hCMPCs on the infarcted mouse myocardium. MI was induced in immunocompromised (NOD/scid) mice, immediately followed by intramyocardial injection of hCMPCs labelled with enhanced green fluorescent protein (hCMPC group) or vehicle only (control group). Sham-operat... Abstract
Cited 46 times since 2012 (3.9 per year) source: EuropePMC
European journal of heart failure, Volume 14, Issue 9, 22 4 2012, Pages 1067-1074 Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle. Borgdorff MA, Bartelds B, Dickinson MG, Boersma B, Weij M, Zandvoort A, Silljé HH, Steendijk P, de Vroomen M, Berger RM
Aim: Right ventricular (RV) failure due to pressure or volume overload is a major risk factor for early mortality in congenital heart disease and pulmonary hypertension, but currently treatments are lacking. We aimed to demonstrate that the phosphodiesterase 5A inhibitor sildenafil can prevent adverse remodelling and improve function in chronic abnormal RV overload, independent from effects on the pulmonary vasculature. Methods and results: In rat models of either pressure or volume overload, we... Abstract
Cited 18 times since 2012 (1.5 per year) source: EuropePMC
Resuscitation, Volume 83, Issue 12, 24 4 2012, Pages 1503-1510 Left ventricular diastolic dysfunction during acute myocardial infarction: effect of mild hypothermia. Schwarzl M, Huber S, Maechler H, Steendijk P, Seiler S, Truschnig-Wilders M, Nestelberger T, Pieske BM, Post H
Background: Mild hypothermia (MH) decreases infarct size and mortality in experimental reperfused myocardial infarction, but may potentiate ischaemia-induced left ventricular (LV) diastolic dysfunction. Methods: In anaesthetized pigs (70 ± 2 kg), polystyrol microspheres (45 μm) were infused repeatedly into the left circumflex artery until cardiac power output decreased >40%. Then, pigs were assigned to normothermia (NT, 38.0°C, n=8) or MH (33.0°C, n=8, intravascular cooling) and followed for... Abstract
Cited 41 times since 2012 (3.4 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 186, Issue 2, 3 1 2012, Pages 181-189 Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study. Kasner M, Westermann D, Steendijk P, Dröse S, Poller W, Schultheiss HP, Tschöpe C
Rationale: Severe increase in right ventricular pressure can compromise left ventricular (LV) function because of impaired interventricular interaction and aggravate the symptoms. Objectives: To elucidate how nonsevere idiopathic pulmonary arterial hypertension (IPAH) influences LV function because of impaired interventricular interaction. Methods: Invasive pressure-volume (PV) loop analysis obtained by conductance catheterization was performed at rest and during atrial pacing in patients with m... Abstract
Cited 13 times since 2012 (1.1 per year) source: EuropePMC
International journal of cardiology, Volume 167, Issue 4, 23 4 2012, Pages 1305-1310 Does left ventricular size impact on intrinsic right ventricular function in hypoplastic left heart syndrome? Schlangen J, Fischer G, Steendijk P, Petko C, Scheewe J, Hart C, Hansen JH, Ahrend F, Rickers C, Kramer HH, Uebing A
Background: The size of the remnant left ventricle (LV) may influence right ventricular function and thus long-term outcome in palliated hypoplastic left heart syndrome (HLHS). We therefore sought to assess the impact of the size of the hypoplastic LV on intrinsic RV function in HLHS patients after Fontan surgery. Methods: Fifty-seven HLHS patients were studied 2.5 (range: 0.8-12.6) years after Fontan-type palliation with the pressure-volume conductance system. The patient cohort was divided int... Abstract
Interactive cardiovascular and thoracic surgery, Volume 15, Issue 1, 19 3 2012, Pages 10-13 Surgical left ventricular radius enlargement by patch insertion on the beating heart: a new experimental aneurysm model. Gründeman PF, van der Spoel TI, Steendijk P, van Slochteren F, Cramer MJ, Doevendans PA, Pasterkamp G
We presented a novel experimental aneurysm model for studies in left ventricular (LV) reconstruction techniques and assessed LV function. In eight pigs, the LV radius and geometry were enlarged surgically on the beating heart by inserting an aortic allograft construct. Haemodynamics and LV dimensions were assessed by echocardiography at baseline and under dobutamine stress. Surgery was successfully performed without lethal blood loss or arrhythmias. LV end-diastolic and end-systolic short-axis a... Abstract
Cited 17 times since 2012 (1.4 per year) source: EuropePMC
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, Volume 37, Issue 2, 1 1 2012, Pages 214-224 Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice. Louwe MC, van der Hoorn JW, van den Berg SA, van den Berg SA, Jukema JW, Romijn JA, van Dijk KW, Rensen PC, Smit JW, Steendijk P
Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and whether this depends on gender and (or) duration of high-fat diet feeding. Male and female C57Bl/6J mice (n = 8 per group) of 12 to 16 weeks old were fe... Abstract
Cited 4 times since 2012 (0.3 per year) source: EuropePMC
Acta anaesthesiologica Scandinavica, Volume 56, Issue 4, 19 3 2012, Pages 449-458 Xenon is not superior to isoflurane on cardiovascular function during experimental acute pulmonary hypertension. Roehl AB, Steendijk P, Rossaint R, Bleilevens C, Goetzenich A, Hein M
Background: Acute right ventricular afterload increase is a known perioperative challenge for the anaesthetic regime especially for patients with a compromised right ventricle. The accused negative inotropic action of volatile anaesthetics, with the exception of xenon, might be crucial for the adaptation of the right ventricle. Methods: Reversible pulmonary hypertension (mean pressure 40 mmHg) was induced by an infusion of the stable thromboxane A(2) analog U46619 in a porcine model (n = 35). Th... Abstract
Cited 31 times since 2012 (2.5 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 14, 9 2 2012, Pages 2 Bramwell-Hill modeling for local aortic pulse wave velocity estimation: a validation study with velocity-encoded cardiovascular magnetic resonance and invasive pressure assessment. Westenberg JJ, van Poelgeest EP, Steendijk P, Grotenhuis HB, Jukema JW, de Roos A
Background: The Bramwell-Hill model describes the relation between vascular wall stiffness expressed in aortic distensibility and the pulse wave velocity (PWV), which is the propagation speed of the systolic pressure wave through the aorta. The main objective of this study was to test the validity of this model locally in the aorta by using PWV-assessments based on in-plane velocity-encoded cardiovascular magnetic resonance (CMR), with invasive pressure measurements serving as the gold standard.... Abstract
Cited 27 times since 2011 (2.1 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 302, Issue 1, 23 4 2011, Pages L56-67 Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats. de Visser YP, Walther FJ, Walther FJ, Laghmani el H, Steendijk P, Middeldorp M, van der Laarse A, Wagenaar GT
Phosphodiesterase (PDE) 4 inhibitors are potent anti-inflammatory drugs with antihypertensive properties, and their therapeutic role in bronchopulmonary dysplasia (BPD) is still controversial. We studied the role of PDE4 inhibition with piclamilast on normal lung development and its therapeutic value on pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) in neonatal rats with hyperoxia-induced lung injury, a valuable model for premature infants with severe BPD. The cardiopulmonar... Abstract
Cited 5 times since 2011 (0.4 per year) source: EuropePMC
European journal of heart failure, Volume 13, Issue 11, 16 3 2011, Pages 1202-1210 Myocardial collagen turnover after surgical ventricular restoration in heart failure patients. ten Brinke EA, Witkowski TG, Delgado V, Klein P, Klok M, Marsan NA, Klautz RJ, van der Wall EE, Bax JJ, van der Laarse A, Steendijk P
Aims: Surgical ventricular restoration (SVR) aims to normalize left ventricular (LV) volume and shape in patients with ischaemic cardiomyopathy and anterior wall scar. The chronic effects on LV function may depend on alterations in myocardial collagen metabolism. The present study evaluated myocardial collagen synthesis and degradation rates at baseline and at 6 months follow-up after SVR. We hypothesize that the chronic effects of SVR on LV function and clinical outcome depend on alterations in... Abstract
Cited 88 times since 2011 (6.9 per year) source: EuropePMC
European heart journal, Volume 33, Issue 16, 4 1 2011, Pages 2098-2108 Aldosterone promotes atrial fibrillation. Reil JC, Hohl M, Selejan S, Lipp P, Drautz F, Kazakow A, Münz BM, Müller P, Steendijk P, Reil GH, Allessie MA, Böhm M, Neuberger HR
Aims: Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF). However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology. Methods: Osmotic mini-pumps delivering 1.5 µg/h aldosterone were implanted subcutaneously in rats (Aldo). Rats without aldosterone treatment served as controls. Afte... Abstract
Cited 23 times since 2011 (1.8 per year) source: EuropePMC
Acta physiologica (Oxford, England), Volume 203, Issue 4, 27 4 2011, Pages 409-418 The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation. Schwarzl M, Steendijk P, Huber S, Truschnig-Wilders M, Obermayer-Pietsch B, Maechler H, Pieske B, Post H
Aim: Mild hypothermia (MH) after cardiac arrest attenuates hypoxic brain injury and improves survival. As MH increases contractility in normal hearts, we hypothesized that MH improves cardiovascular function after cardiac arrest. Methods: In 16 anaesthetized pigs (64 ± 2 kg), ventricular fibrillation was induced electrically for 5 min. At 10 min after resuscitation and return of spontaneous circulation (ROSC), pigs were assigned to normothermia (NT, 38°C, n = 8) or MH (33°C, n = 8, intravascular... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
Critical care (London, England), Volume 15, Issue 1, 9 2 2011, Pages 119 Cardiovascular consequences of cooling in critical care. Steendijk P
This commentary discusses a paper by Filseth and colleagues in a previous issue of Critical Care. The authors describe the cardiovascular effects of induced hypothermia, focusing particularly on post-hypothermic ventricular function. The findings indicate that the treatment resulted in reduced systolic but unchanged diastolic left ventricular function with compensatory effects on heart rate and systemic vascular resistance. The novel aspects of this study are the registration of ventricular func... Abstract
Cited 19 times since 2011 (1.4 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 91, Issue 2, 1 1 2011, Pages 491-498 Surgical ventricular restoration for patients with ischemic heart failure: determinants of two-year survival. Witkowski TG, ten Brinke EA, Delgado V, Ng AC, Bertini M, Marsan NA, Ewe SH, Auger D, Yiu KH, Braun J, Klein P, Steendijk P, Versteegh MI, Klautz RJ, Bax JJ
Background: Surgical ventricular restoration (SVR) improves left ventricular (LV) systolic function by partially restoring the normal geometry of the left ventricle. However, the beneficial effects of this surgical procedure on long-term clinical outcome remain controversial. The present study aimed to evaluate the independent determinants of 2-year morbidity and mortality rates after SVR. Methods: Seventy-nine patients with ischemic heart disease and LV ejection fraction of 0.35 or less were in... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
Cardiology journal, Volume 18, Issue 3, 1 1 2011, Pages 289-296 Interventional creation of an atrial septal defect and its impact on right ventricular function: an animal study with the pressure-volume conductance system. Uebing A, Fischer G, Schlangen J, Hansen T, Grabitz RG, Becker K, Steendijk P, Kramer HH
Background: The aim of our study was to assess the suitability of different interventional techniques to create an atrial septal defect (ASD) and to evaluate the short-term effects of right ventricular (RV) volume overload on RV contractility in the growing swine. Methods: Thirteen ASD and six control animals were studied. An ASD was created by balloon dilatation (BD) of the fossa ovalis (n = 4) or by implantation of a multi-perforated Amplatzer Septal Occluder (n = 4) or a patch-less nitinol de... Abstract
Cited 13 times since 2010 (1 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 22, Issue 6, 6 1 2010, Pages 677-683 Upgrading to biventricular pacing guided by pressure-volume loop analysis during implantation. Delnoy PP, Ottervanger JP, Vos DH, Elvan A, Misier AR, Beukema WP, Steendijk P, van Hemel NM
Introduction: cardiac resynchronization therapy (CRT) may improve prognosis in patients with chronic right ventricular (RV) pacing, and optimal lead position can decrease nonresponders. We evaluated the clinical and echocardiographic response to CRT in patients with previous chronic RV pacing, using pressure-volume loop analyses to determine the optimal left ventricular (LV) lead position during implantation. Methods and results: In this single-blinded, randomized, controlled crossover study, 40... Abstract
Cited 16 times since 2010 (1.2 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 90, Issue 6, 1 1 2010, Pages 1913-1920 Clinical and functional effects of restrictive mitral annuloplasty at midterm follow-up in heart failure patients. ten Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Delgado V, Holman ER, Schalij MJ, van der Wall EE, Braun J, Versteegh MI, Dion RA, Steendijk P
Background: Restrictive mitral annuloplasty (RMA) is increasingly applied to treat functional mitral regurgitation in heart failure patients. Previous studies indicated beneficial clinical effects with low recurrence rates. However, the underlying pathophysiology is complex and outcome in terms of left ventricular function is not well known. We investigated chronic effects of RMA on ventricular function in relation to clinical outcome. Methods: Heart failure patients (n = 11) with severe mitral... Abstract