Research

Publications

Below you can find a list of our published research.

876 results

Heart (British Cardiac Society), 11 2 2023, Pages heartjnl-2022-322332 Tolerability and beneficial effects of sacubitril/valsartan on systemic right ventricular failure. Nederend M, Kiès P, Regeer MV, Vliegen HW, Mertens BJ, Robbers-Visser D, Bouma BJ, Tops LF, Schalij MJ, Jongbloed MRM, Egorova AD

Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV. Methods: In this two-centre, prospective cohort study, all consecutive adult patients with symptomatic h... Abstract

Cited 1 times since 2023 (5.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 31, Issue 5, 29 5 2023, Pages 202-209 Improved prehospital triage for acute cardiac care: results from HART-c, a multicentre prospective study. de Koning ER, Beeres SLMA, Bosch J, Backus BE, Tietge WJ, Alizadeh Dehnavi R, Groenwold RHH, Silvius AM, van Lierop PTS, Jukema JW, Schalij MJ, Boogers MJ

Background: Cardiac symptoms are one of the most prevalent reasons for emergency department visits. However, over 80% of patients with such symptoms are sent home after acute cardiovascular disease has been ruled out. Objective: The Hollands-Midden Acute Regional Triage-cardiology (HART-c) study aimed to investigate whether a novel prehospital triage method, combining prehospital and hospital data with expert consultation, could increase the number of patients who could safely stay at home after... Abstract

Journal of cardiovascular development and disease, Volume 10, Issue 3, 17 3 2023, Pages 129 Contemporary Management Strategies of Baffle Leaks in Adults with a Failing Systemic Right Ventricle Late after Atrial Switch: A Case Series and Literature Overview. Neijenhuis RML, Regeer MV, van der Kley F, Vliegen HW, Jongbloed MRM, Kiès P, Schalij MJ, Jukema JW, Egorova AD

Baffle leaks are a frequently encountered and often overlooked complication after the atrial switch procedure for transposition of the great arteries. Baffle leaks are present in up to 50% of non-selected patients, and while they initially may not cause clear symptoms, they can complicate the hemodynamic course and influence the prognosis in this complex patient group. A shunt from the pulmonary venous atrium (PVA) to the systemic venous atrium (SVA) can lead to pulmonary overflow and subpulmona... Abstract

American heart journal plus : cardiology research and practice, Volume 27, 23 4 2023, Pages 100280 Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks. Groen RA, de Graaf MA, Stöger JL, van Dijkman PRM, Jukema JW, Schalij MJ, Geelhoed JJM, Antoni ML

Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 25, Issue 1, 1 1 2023, Pages 49-58 Mobile health vs. standard care after cardiac surgery: results of The Box 2.0 study. Biersteker TE, Boogers MJ, Schalij MJ, Penning de Vries BBL, Groenwold RHH, van Alem AP, de Weger A, van Hof N, Treskes RW

Aims: Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery, yet difficult to detect in ambulatory patients. The primary aim of this study is to investigate the effect of a mobile health (mHealth) intervention on POAF detection after cardiac surgery. Methods and results: We performed an observational cohort study among 730 adult patients who underwent cardiac surgery at a tertiary care hospital in The Netherlands. Of these patients, 365 patients received standard c... Abstract

Frontiers in cardiovascular medicine, Volume 9, 22 4 2022, Pages 1012147 A percutaneous treatment strategy of an adult patient with a bicuspid aortic valve, coarctation of the aorta, and an exceptionally large aneurysm of a collateral artery: Case report and literature overview. Verheijen DBH, Stöger JL, van der Kley F, Schalij MJ, Jongbloed MRM, Vliegen HW, Kiès P, Egorova AD

Coarctation of the aorta (CoA) is a congenital heart defect that is associated with a bicuspid aortic valve (BAV), ascending aorta dilatation, intracerebral aneurysms, and premature atherosclerotic disease. The first presentation during late adulthood is rare and is frequently driven by late sequelae. Hypertrophic collateral arteries can develop aneurysms which are at risk for spontaneous rupture, however, treatment recommendations for these aneurysms are scarce. Here, we describe the clinical c... Abstract

Clinical nutrition (Edinburgh, Scotland), Volume 42, Issue 1, 17 3 2022, Pages 18-21 An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities. de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE

Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings... Abstract

Frontiers in cardiovascular medicine, Volume 9, 13 2 2022, Pages 946404 The development of a decision aid for shared decision making in the Dutch implantable cardioverter defibrillator patient population: A novel approach to patient education. Yilmaz D, Egorova AD, Schalij MJ, Spierenburg HAM, Verbunt RAM, van Erven L

Background: Counseling of Implantable Cardioverter-defibrillator (ICD) patients with regard to individual risks and benefits is challenging. An evidence-based decision aid tailored to the needs of Dutch ICD patients is not yet available. The objective of this pilot project was to structurally evaluate the current clinical practice in The Netherlands and the ICD patient experience, in order to develop an online decision aid to facilitate shared decision making in ICD procedures. Methods: Between... Abstract

Prehospital and disaster medicine, Volume 37, Issue 5, 11 2 2022, Pages 600-608 Managing Hospital Capacity: Achievements and Lessons from the COVID-19 Pandemic. de Koning ER, Boogers MJ, Beeres SL, Kramer ID, Dannenberg WJ, Schalij MJ

Introduction: The coronavirus disease 2019 (COVID-19) pandemic challenged health care systems in an unprecedented way. Due to the enormous amount of hospital ward and intensive care unit (ICU) admissions, regular care came to a standstill, thereby overcrowding ICUs and endangering (regular and COVID-19-related) critical care. Acute care coordination centers were set up to safely manage the influx of COVID-19 patients. Furthermore, treatments requiring ICU surveillance were postponed leading to i... Abstract

Cited 1 times since 2022 (1.1 per year) source: EuropePMC

Cardiovascular research, Volume 118, Issue 10, 1 1 2022, Pages 2293-2303 Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model. Nyns ECA, Jin T, Fontes MS, van den Heuvel T, Portero V, Ramsey C, Bart CI, Zeppenfeld K, Schalij MJ, van Brakel TJ, Ramkisoensing AA, Zhang G, Poelma RH, Ördög B, de Vries AAF, Pijnappels DA

Aims: Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute treatment like electrical cardioversion to restore normal rhythm. Recently, it has been proposed that cardioversion may also be realized via optically controlled generation of bioelectricity by the arrhythmic heart itself through optogenetics and therefore without the need of traumatizing high-voltage shocks. However, crucial mechanistic and translation... Abstract

Circulation research, Volume 131, Issue 1, 19 3 2022, Pages 24-41 Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity. van Gorp PRR, Zhang J, Liu J, Tsonaka R, Mei H, Dekker SO, Bart CI, De Coster T, Post H, Heck AJR, Schalij MJ, Atsma DE, Pijnappels DA, de Vries AAF

Background: Heart development relies on tight spatiotemporal control of cardiac gene expression. Genes involved in this intricate process have been identified using animals and pluripotent stem cell-based models of cardio(myo)genesis. Recently, the repertoire of cardiomyocyte differentiation models has been expanded with iAM-1, a monoclonal line of conditionally immortalized neonatal rat atrial myocytes (NRAMs), which allows toggling between proliferative and differentiated (ie, excitable and co... Abstract

Frontiers in cardiovascular medicine, Volume 9, 10 2 2022, Pages 870459 Atrioventricular Block Necessitating Chronic Ventricular Pacing After Tricuspid Valve Surgery in Patients With a Systemic Right Ventricle: Long-Term Follow-Up. Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Regeer MV, Koolbergen DR, Hazekamp MG, Schalij MJ, Egorova AD

Background: Patients with transposition of the great arteries (TGA) after an atrial switch or congenitally corrected TGA (ccTGA) are prone to systemic right ventricular (sRV) failure. Tricuspid valve (TV) regurgitation aggravates sRV dysfunction. Timely TV surgery stabilizes sRV function, yet the development of atrioventricular (AV)-conduction disturbances in the course of sRV failure can contribute to sRV dysfunction through pacing-induced dyssynchrony. This study aims to explore the incidence,... Abstract

Cancers, Volume 14, Issue 9, 8 2 2022, Pages 2329 Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors. Polomski EAS, Heemelaar JC, Krol ADG, Louwerens M, Beeres SLMA, Holman ER, Jukema JW, Schalij MJ, Antoni ML

Background: Treatment with thoracic irradiation for classic Hodgkin lymphoma (CHL) leads to improved survival but also increases the risk of cardiovascular events. Left ventricular (LV) dysfunction is usually assessed by echocardiographic left ventricular ejection fraction (LVEF), whereas global longitudinal strain (GLS) can detect early subclinical LV dysfunction. The purpose of this study was to evaluate if conventional echocardiographic parameters and GLS are associated with cardiovascular ev... Abstract

Cited 3 times since 2022 (2.8 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 6 1 2022, Pages 883873 Performance of a HeartLogic<sup>TM</sup> Based Care Path in the Management of a Real-World Chronic Heart Failure Population. Feijen M, Egorova AD, Treskes RW, Mertens BJA, Jukema JW, Schalij MJ, Beeres SLMA

Aim: Early detection of impending fluid retention and timely adjustment of (medical) therapy can prevent heart failure related hospitalizations. The multisensory cardiac implantable electronic device (CIED) based algorithm HeartLogicTM aims to alert in case of impending fluid retention. The aim of the current analysis is to evaluate the performance of the HeartLogicTM guided heart failure care path in a real-world heart failure population and to investigate whether the height of the index and th... Abstract

European heart journal open, Volume 2, Issue 4, 2 1 2022, Pages oeac031 A comprehensive analysis of the intramural segment in interarterial anomalous coronary arteries using computed tomography angiography. Koppel CJ, Verheijen DBH, Kiès P, Egorova AD, Lamb HJ, Voskuil M, Jukema JW, Koolbergen DR, Hazekamp MG, Schalij MJ, Jongbloed MRM, Vliegen HW

Aims: An anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS) with an interarterial course can be assessed using computed tomography angiography (CTA) for the presence of high-risk characteristics associated with sudden cardiac death. These features include a slit-like ostium, acute angle take-off, proximal luminal narrowing, and an intramural segment. To date, no robust CTA criteria exist to determine the presence of an intramural segment. We aimed to deduct new CTA... Abstract

Cited 1 times since 2022 (0.9 per year) source: EuropePMC

Journal of medical Internet research, Volume 24, Issue 4, 25 4 2022, Pages e30236 The Box-eHealth in the Outpatient Clinic Follow-up of Patients With Acute Myocardial Infarction: Cost-Utility Analysis. Treskes RW, van den Akker-van Marle ME, van Winden L, van Keulen N, van der Velde ET, Beeres S, Atsma D, Schalij MJ

Background: Smartphone compatible wearables have been released on the consumers market, enabling remote monitoring. Remote monitoring is often named as a tool to reduce the cost of care. Objective: The primary purpose of this paper is to describe a cost-utility analysis of an eHealth intervention compared to regular follow-up in patients with acute myocardial infarction (AMI). Methods: In this trial, of which clinical results have been published previously, patients with an AMI were randomized i... Abstract

Cardiology and cardiovascular medicine, Volume 6, Issue 2, 14 2 2022, Pages 171-188 Development of Central Venous Stenosis Upon ICD Implantation in Dialysis Patients: A Non-Negligible Issue. Timal RJ, Karalis I, Cabezas JMM, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, van Erven L, Putter H, Schalij MJ, Rabelink TJ, Jukema JW

Background: In hemodialysis patients, implantable cardioverter-defibrillator (ICD) implantation may result in central venous stenosis (CVS) with associated symptoms, such as pain, edema of the ipsilateral arm, facial edema, and loss of dialysis access. However, literature concerning CVS in dialysis patients with a cardiac implantable electronic device is scarce. Methods: We conducted a prospective cohort study in which we investigated the incidence of CVS in end-stage renal disease patients on c... Abstract

Frontiers in cardiovascular medicine, Volume 8, 15 3 2022, Pages 779075 Continuum of Care: Positioning of the Virtual Hospital. van der Lande ACMH, Treskes RW, Beeres SLMA, Schalij MJ

Introduction: Patients with multiple chronic diseases suffer from reduced life expectancy. Care for these patients is often divided over multiple healthcare professionals. eHealth might help to integrate care for these patients and create a continuum. It is the primary purpose of this paper to describe an intervention that integrates first, second, and third line care in patients with multiple chronic conditions using remote monitoring, remote therapy and data automatization, all integrated in a... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 9, 11 2 2022, Pages 431-435 Emergency Heart failure Mortality Risk Grade may help to reduce heart failure admissions. van Hattem NE, Beeres SLMA, Mertens BJA, Antoni ML, Atsma DE, Schalij MJ, den Haan MC

Introduction: Hospital admissions for heart failure (HF) are frequent and pose a heavy burden on health care resources. Currently, the decision to hospitalise is based on clinical judgement rather than on prognostic risk stratification. The Emergency Heart failure Mortality Risk Grade (EHMRG) was recently developed to identify high-risk HF patients in the emergency department (ED). Objective: To assess the ability of the EHMRG to predict 30-day mortality in Dutch HF patients visiting the ED and... Abstract

Cited 1 times since 2022 (0.8 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 21, Issue 2, 1 1 2022, Pages 169-173 Implantable cardioverter-defibrillators and the older patient: the Dutch clinical practice. Yilmaz D, Egorova AD, Schalij MJ, van Erven L

Background and objective: Balance between benefit and burden of implantable cardioverter-defibrillator (ICD) therapy is more debatable in older patients, compared to younger patients. Of around 6000 yearly implanted ICDs in the Netherlands, 1:4 is received by patients ≥75 years. We aimed to evaluate the current clinical practice in the Netherlands for ICD implants and generator replacements, with a special focus on the older ICD patients. Research design and methods: Cardiologists from all Dutch... Abstract