Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
511 results
Cited 12 times since 2014 (1.3 per year) source: EuropePMC
Respirology (Carlton, Vic.), Volume 19, Issue 8, 1 1 2014, Pages 1248-1250 The pathogenesis of pneumothorax in Birt-Hogg-Dubé syndrome: a hypothesis. Johannesma PC, Houweling AC, van Waesberghe JH, van Moorselaar RJ, Starink TM, Menko FH, Postmus PE
The development and natural course of lung cysts in patients with Birt-Hogg-Dubé syndrome (BHD) is still unclear, and the relationship between lung cysts and pneumothorax is not fully clarified. Based on the follow-up results of thoracic imaging in six patients with BHD, we hypothesize that decreased potential for stretching of the cysts' wall and extensive contact with the visceral pleura are probably responsible for rupture of the cyst wall resulting in increased risk for pneumothorax. Abstract
Cited 9 times since 2014 (0.9 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 190, Issue 6, 1 1 2014, Pages 704-705 In-flight pneumothorax: diagnosis may be missed because of symptom delay. Postmus PE, Johannesma PC, Menko FH, Paul MA
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
Respiratory medicine case reports, Volume 13, 12 2 2014, Pages 26-27 Benefit of a second opinion: From metastatic disease to resectable lung cancer with sarcoid-like reaction. Schook RM, Koudstaal L, Comans EF, Postmus PE, Grünberg K, Paul MA, Smit EF, Sutedja TG
Background: Mediastinal lymphadenopathy in combination with lung cancer is suggestive for lymph node metastases but can also have other origins. Case report: We describe a patient diagnosed with stage IV lung cancer presenting with parenchymal lesions and enlarged mediastinal lymph nodes. A second opinion including FDG-PET scan review and a mediastinoscopy followed by surgery revealed tumor specimens originating from a single primary tumor with a sarcoid-like reaction in the mediastinal lymph no... Abstract
Cited 21 times since 2014 (2.2 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 86, Issue 1, 2 1 2014, Pages 73-77 Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy. Mellema WW, van der Hoek D, Postmus PE, Smit EF
Objectives: Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment with platinum-based chemotherapy. Methods: We retrospectively selected patients with NSCLC treated with platinum-based chemotherapy at the VU University Medical Center Am... Abstract
Cited 8 times since 2014 (0.8 per year) source: EuropePMC
BMC pediatrics, Volume 14, 3 1 2014, Pages 171 Spontaneous pneumothorax as indicator for Birt-Hogg-Dubé syndrome in paediatric patients. Johannesma PC, van den Borne BE, Gille JJ, Nagelkerke AF, van Waesberghe JT, Paul MA, van Moorselaar RJ, Menko FH, Postmus PE
Background: Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominantly inherited disorder caused by germline mutations in the folliculin (FLCN) gene. Clinical manifestations of BHD include skin fibrofolliculomas, renal cell cancer, lung cysts and (recurrent) spontaneous pneumothorax (SP). All clinical manifestations usually present in adults > 20 years of age. Case presentations: Two non-related patients with (recurrent) pneumothorax starting at age 14 accompanied by multiple basal lung cys... Abstract
Japanese journal of clinical oncology, Volume 44, Issue 6, 1 1 2014, Pages 609-610 Facial fibrofolliculomas as indicator for renal cell cancer. Johannesma PC, Starink TM, Van Moorselaar RJ, Postmus PE
Cited 116 times since 2014 (11.5 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 85, Issue 1, 23 4 2014, Pages 19-24 Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients. Kuiper JL, Heideman DA, Thunnissen E, Paul MA, van Wijk AW, Postmus PE, Smit EF
Aim: Non-small cell lung cancer (NSCLC)-patients with an epidermal growth factor receptor (EGFR)-mutation have median progression-free survival (PFS) of 12 months on tyrosine kinase inhibitors (TKIs). Resistance is mediated by the EGFR T790M-mutation in the majority of patients. Longitudinal follow-up data are lacking. We retrospectively evaluated EGFR-mutated NSCLC-patients who were rebiopsied after TKI-treatment. A subgroup was sequentially rebiopsied along the course of the disease. Patients... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
Case reports in medicine, Volume 2014, 20 3 2014, Pages 618675 Bilateral renal tumour as indicator for birt-hogg-dubé syndrome. Johannesma PC, van Moorselaar RJ, Horenblas S, van der Kolk LE, Thunnissen E, van Waesberghe JH, Menko FH, Postmus PE
Birt-Hogg-Dubé (BHD) syndrome is a cancer disorder caused by a pathogenic FLCN mutation characterized by fibrofolliculomas, lung cysts, pneumothorax, benign renal cyst, and renal cell carcinoma (RCC). In this case we describe a patient with bilateral renal tumour and a positive familial history for pneumothorax and renal cancer. Based on this clinical presentation, the patient was suspected for BHD syndrome, which was confirmed after molecular testing. We discuss the importance of recognizing th... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
Histopathology, Volume 64, Issue 7, 8 2 2014, Pages 1045-1046 How reliable are clinical criteria in distinguishing between Birt-Hogg-Dubé syndrome and smoking as a cause for pneumothorax? Johannesma PC, Thunnissen E, Postmus PE
Cited 6 times since 2014 (0.6 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 50, Issue 7, 28 4 2014, Pages 1399-1401 High-dose, weekly erlotinib is not an effective treatment in EGFR-mutated non-small cell lung cancer-patients with acquired extracranial progressive disease on standard dose erlotinib. Kuiper JL, Heideman DA, Thunnissen E, van Wijk AW, Postmus PE, Smit EF
Cited 17 times since 2014 (1.7 per year) source: EuropePMC
Journal of medical Internet research, Volume 16, Issue 2, 4 1 2014, Pages e37 Why do patients and caregivers seek answers from the Internet and online lung specialists? A qualitative study. Schook RM, Linssen C, Schramel FM, Festen J, Lammers E, Smit EF, Postmus PE, Westerman MJ
Background: Since its launch in 2003, the Dutch Lung Cancer Information Center's (DLIC) website has become increasingly popular. The most popular page of the website is the section "Ask the Physician", where visitors can ask an online lung specialist questions anonymously and receive an answer quickly. Most questions were not only asked by lung cancer patients but also by their informal caregivers. Most questions concerned specific information about lung cancer. Objective: Our goa... Abstract
Cited 2 times since 2014 (0.2 per year) source: EuropePMC
Case reports in oncology, Volume 7, Issue 1, 1 1 2014, Pages 122-125 Benefit of a second opinion for lung cancer: no metastasis to the kidney but a synchronous primary renal neoplasm. Ter Avest MJ, Schook RM, Koudstaal LG, Grünberg K, Paul MA, Smit EF, Postmus PE
Background: The finding of a renal mass on imaging is suggestive of metastatic non-small cell lung cancer in the presence of a lung tumor but can also have another origin. Case report: We describe the case of a patient diagnosed with stage IV lung cancer based on a renal metastasis. A second opinion including review of histopathological data and additional imaging followed by lung surgery and cryoablation of the kidney lesion revealed two tumors of different origins, non-small cell lung cancer a... Abstract
Cited 8 times since 2013 (0.8 per year) source: EuropePMC
Thorax, Volume 69, Issue 5, 13 2 2013, Pages 451-457 DNA copy number aberrations in endobronchial lesions: a validated predictor for cancer. van Boerdonk RA, Daniels JM, Snijders PJ, Grünberg K, Thunnissen E, van de Wiel MA, Ylstra B, Postmus PE, Meijer CJ, Meijer GA, Smit EF, Sutedja TG, Heideman DA
We recently identified a DNA copy number aberration (CNA)-based classifier, including changes at 3p26.3-p11.1, 3q26.2-29, and 6p25.3-24.3, as a risk predictor for cancer in individuals presenting with endobronchial squamous metaplasia. The current study was set out to validate the prediction accuracy of this classifier in an independent series of endobronchial squamous metaplastic and dysplastic lesions. The study included 36 high-risk subjects who had endobronchial lesions of various histologic... Abstract
Cited 4 times since 2013 (0.4 per year) source: EuropePMC
Lung, Volume 192, Issue 1, 22 4 2013, Pages 215-216 Lung cysts as indicator for Birt-Hogg-Dubé syndrome. Johannesma PC, Thunnissen E, Postmus PE
In this case, we describe a patient with a history of recurrent pneumothorax. Based on CT-thorax and histopathology of the lung tissue, the Birt-Hogg-Dubé syndrome was suspected and confirmed after genetic testing. Recognizing this syndrome by pulmonologists and radiologists is very important, because the risk on developing of renal cell cancer is high. Abstract
Cited 183 times since 2013 (17.3 per year) source: EuropePMC
Circulation, Volume 128, Issue 18, 20 3 2013, Pages 2016-25, 1-10 Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Rain S, Handoko ML, Trip P, Gan CT, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CA, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS
Background: The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH patients. Methods and results: Single-beat RV pressure-volume analyses were performed in 21 PAH patients and 7 control subjects to study RV diastolic stiffness. Data are presented as mean ± SEM. RV diastolic stiffness (β) was significantly increased in PAH pa... Abstract
Cited 14 times since 2013 (1.3 per year) source: EuropePMC
Familial cancer, Volume 12, Issue 3, 1 1 2013, Pages 373-379 A de novo FLCN mutation in a patient with spontaneous pneumothorax and renal cancer; a clinical and molecular evaluation. Menko FH, Johannesma PC, van Moorselaar RJ, Reinhard R, van Waesberghe JH, Thunnissen E, Houweling AC, Leter EM, Waisfisz Q, van Doorn MB, Starink TM, Postmus PE, Coull BJ, van Steensel MA, Gille JJ
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant condition due to germline FLCN (folliculin) mutations, characterized by skin fibrofolliculomas, lung cysts, pneumothorax and renal cancer. We identified a de novo FLCN mutation, c.499C>T (p.Gln167X), in a patient who presented with spontaneous pneumothorax. Subsequently, typical skin features and asymptomatic renal cancer were diagnosed. Probably, de novo FLCN mutations are rare. However, they may be under-diagnosed if BHD is not consider... Abstract
Cited 7 times since 2013 (0.7 per year) source: EuropePMC
Interactive journal of medical research, Volume 2, Issue 2, 6 1 2013, Pages e15 Website visitors asking questions online to lung cancer specialists: what do they want to know? Schook RM, Linssen C, Festen J, Schramel FM, Lammers E, Zaanen P, Postmus PE
Background: In 2003 the Dutch Lung Cancer Information Centre (Longkanker Informatie Centrum) launched a website containing information on lung cancer accessible to anyone. Objective: Our study aim was to inventorize the information needs of the visitors of this website by analyzing the questions they asked the lung cancer specialists in the websites interactive section "Ask the Physician". Methods: The first 2000 questions posted up until May 2006 have been classified by visitors'... Abstract
Cited 20 times since 2013 (1.9 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 82, Issue 1, 5 1 2013, Pages 38-43 EGFR mutation analysis in sputum of lung cancer patients: a multitechnique study. Hubers AJ, Heideman DA, Yatabe Y, Wood MD, Tull J, Tarón M, Molina MA, Mayo C, Bertran-Alamillo J, Herder GJ, Koning R, Sie D, Ylstra B, Meijer GA, Snijders PJ, Witte BI, Postmus PE, Smit EF, Thunnissen E
Objectives: Epidermal growth factor receptor (EGFR) mutations have been identified in lung adenocarcinomas and are associated with high response chance to EGFR tyrosine kinase inhibitors. EGFR mutations can be detected in tumour tissue, cytology specimens and blood from lung cancer patients. Thus far, EGFR mutation analysis has not been systematically demonstrated for sputum samples. The aim of the present study was to determine whether EGFR mutation analysis is attainable on sputum samples, emp... Abstract
Cited 2 times since 2013 (0.2 per year) source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 8, Issue 6, 1 1 2013, Pages e54-6 Benefit of a second opinion: intrapulmonary metastases or multiple primary tumors? ter Avest MJ, Schook RM, Postmus PE, Grünberg K, Ylstra B, Paul MA
Cited 75 times since 2013 (6.8 per year) source: EuropePMC
Chest, Volume 143, Issue 5 Suppl, 1 1 2013, Pages e191S-e210S The stage classification of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Detterbeck FC, Postmus PE, Tanoue LT
The current Lung Cancer Stage Classification system is the seventh edition, which took effect in January 2010. This article reviews the definitions for the TNM descriptors and the stage grouping in this system. Abstract