Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
55 results
Cited 2 times since 2020 (0.6 per year) source: EuropePMC
Thrombosis research, Volume 199, 19 3 2020, Pages 32-34 Computed tomography pulmonary perfusion imaging and 3-months clinical outcomes after acute pulmonary embolism. van Dam LF, Kroft LJM, Boon GJAM, Huisman MV, Ninaber MK, Klok FA
Cited 13 times since 2020 (3.6 per year) source: EuropePMC
Arthritis & rheumatology (Hoboken, N.J.), Volume 72, Issue 11, 29 5 2020, Pages 1897-1904 Association of Anti-Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti-Topoisomerase I-Positive Systemic Sclerosis. Boonstra M, Bakker JA, Grummels A, Ninaber MK, Ajmone Marsan N, Wortel CM, Huizinga TWJ, Jordan S, Hoffman-Vold AM, Distler O, Toes REM, Scherer HU, de Vries-Bouwstra JK
Objective: Anti-topoisomerase I (anti-topo I) autoantibodies in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relationship between anti-topo I antibody response and disease course has not yet been fully evaluated. This study was undertaken to gain insight into the association between characteristics of the anti-topo I antibody response and clinical disease course in SSc patients positive for anti-topo I antibodies. Me... Abstract
Cited 3 times since 2020 (0.8 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 22, Issue 9, 1 1 2020, Pages 1376-1383 The harm of delayed diagnosis of arrhythmogenic cardiac sarcoidosis: a case series. Hoogendoorn JC, Ninaber MK, Piers SRD, de Riva M, Grauss RW, Bogun FM, Zeppenfeld K
Aims: Cardiac sarcoidosis (CS) is a known cause of ventricular tachycardia (VT). However, an arrhythmogenic presentation may not prompt immediate comprehensive evaluation. We aimed to assess the diagnostic and disease course of patients with arrhythmogenic cardiac sarcoidosis (ACS). Methods and results: From the Leiden VT-ablation-registry, consecutive patients with CS as underlying aetiology were retrospectively included. Data on clinical presentation, time-to-diagnosis, cardiac function, and c... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
Clinical rheumatology, Volume 39, Issue 5, 24 4 2020, Pages 1543-1549 Lung function is associated with minimal EQ-5D changes over time in patients with systemic sclerosis. Ciaffi J, van Leeuwen NM, Liem SIE, Ninaber MK, Huizinga TWJ, de Vries-Bouwstra JK
In systemic sclerosis (SSc) therapeutic efforts are often directed to prevent progressive respiratory impairment, but it is unclear to what extent changes in pulmonary function tests (PFTs) are associated with health-related quality of life (HRQoL). The aim of our study is to evaluate how modifications in PFTs contribute to longitudinal variations in HRQoL, assessed through the multidimensional questionnaire EQ-5D, in patients with SSc. We included SSc patients with forced vital capacity (FVC%),... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
Psychosomatic medicine, Volume 81, Issue 9, 1 1 2019, Pages 841-850 Antipruritic Placebo Effects by Conditioning H1-antihistamine. Meeuwis SH, van Middendorp H, Pacheco-Lopez G, Ninaber MK, Lavrijsen APM, van der Wee N, Veldhuijzen DS, Evers AWM
Objective: Allergic rhinitis symptoms can be reduced by behaviorally conditioning antihistamine. It is unclear whether these findings extend to histamine-induced itch or work when participants are informed about the conditioning procedure (open-label conditioning). The current study aims to investigate the efficacy of (open-label) antipruritic behavioral conditioning for histamine-induced itch. Methods: Healthy participants (n = 92; 84% female) were randomized to I) an open-label conditioned, II... Abstract
Cited 3 times since 2019 (0.7 per year) source: EuropePMC
Journal of thoracic imaging, Volume 34, Issue 6, 1 1 2019, Pages 373-379 Pulmonary Vascular Morphology Associated With Gas Exchange in Systemic Sclerosis Without Lung Fibrosis. Zhai Z, Staring M, Ninaber MK, Vries-Bouwstra JK, Schouffoer AA, Kroft LJ, Stolk J, Stoel BC
Purpose: Gas exchange in systemic sclerosis (SSc) is known to be affected by fibrotic changes in the pulmonary parenchyma. However, SSc patients without detectable fibrosis can still have impaired gas transfer. We aim to investigate whether pulmonary vascular changes could partly explain a reduction in gas transfer of SSc patients without fibrosis. Materials and methods: We selected 77 patients whose visual computed tomography (CT) scoring showed no fibrosis. Pulmonary vessels were detected auto... Abstract
Cited 8 times since 2019 (1.7 per year) source: EuropePMC
Medical physics, Volume 46, Issue 9, 9 2 2019, Pages 3985-3997 Automatic quantitative analysis of pulmonary vascular morphology in CT images. Zhai Z, Staring M, Hernández Girón I, Veldkamp WJH, Kroft LJ, Ninaber MK, Stoel BC
Purpose: Vascular remodeling is a significant pathological feature of various pulmonary diseases, which may be assessed by quantitative computed tomography (CT) imaging. The purpose of this study was therefore to develop and validate an automatic method for quantifying pulmonary vascular morphology in CT images. Methods: The proposed method consists of pulmonary vessel extraction and quantification. For extracting pulmonary vessels, a graph-cuts-based method is proposed which considers appearanc... Abstract
The Journal of rheumatology, Volume 46, Issue 9, 1 1 2019, Pages 1244-1245 Degree of Vasculopathy in Systemic Sclerosis Patients with Anti-U3RNP Antibody Indicates Need for Extensive Cardiopulmonary Screening. VAN Leeuwen NM, Boonstra M, Ajmone Marsan N, Ninaber MK, Huizinga TWJ, DE Vries-Bouwstra JK
Journal of scleroderma and related disorders, Volume 5, Issue 2, 7 1 2019, Pages NP1-NP4 Pulmonary veno-occlusive disease in a patient with recently diagnosed systemic sclerosis. van Leeuwen NM, Ramiro S, Ninaber MK, Nossent E, de Vries-Bouwstra JK
Pulmonary veno-occlusive disease is a rare cause of pulmonary hypertension in patients with systemic sclerosis that can be misclassified as pulmonary arterial hypertension. Differentiation between pulmonary veno-occlusive disease and pulmonary arterial hypertension is challenging because of the similar clinical picture. Nevertheless, discrimination is important because pulmonary veno-occlusive disease has a worse prognosis. Vasodilators including phosphodiesterase type 5 inhibitors and endotheli... Abstract
Cited 7 times since 2019 (1.4 per year) source: EuropePMC
Rheumatology (Oxford, England), Volume 58, Issue 4, 1 1 2019, Pages 730-732 Prognostic properties of anti-topoisomerase antibodies in patients identified by the ACR/EULAR 2013 systemic sclerosis criteria. Boonstra M, Ninaber MK, Ajmone Marsan N, Huizinga TWJ, Scherer HU, de Vries-Bouwstra JK
Cited 8 times since 2019 (1.6 per year) source: EuropePMC
The Journal of rheumatology, Volume 46, Issue 4, 1 1 2019, Pages 405-415 Progression of Left Ventricular Myocardial Dysfunction in Systemic Sclerosis: A Speckle-tracking Strain Echocardiography Study. van Wijngaarden SE, Ben Said-Bouyeri S, Ninaber MK, Huizinga TWJ, Schalij MJ, Bax JJ, Delgado V, de Vries-Bouwstra JK, Marsan NA
Objective: Cardiac involvement is a main cause of mortality in systemic sclerosis (SSc). Its detection remains challenging using conventional echocardiography and little is known about its potential progression. This study assessed changes in cardiac performance over time in a prospective cohort of patients with SSc, including echocardiographic speckle-tracking strain analysis. Methods: The study included 234 patients with SSc [196 women, age 52 ± 14 yrs, 165 limited SSc, time since diagnosis 5.... Abstract
Cited 26 times since 2019 (5 per year) source: EuropePMC
The European respiratory journal, Volume 53, Issue 2, 7 1 2019, Pages 1800800 Systematic and combined endosonographic staging of lung cancer (SCORE study). Crombag LMM, Dooms C, Stigt JA, Tournoy KG, Schuurbiers OCJ, Ninaber MK, Buikhuisen WA, Hashemi SMS, Bonta PI, Korevaar DA, Annema JT
Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging versus the current practice of targeted positron emission tomography (PET)-computed tomography (CT)-guided EBUS staging alone.A prospective, multicentre, international study (N... Abstract
Cited 7 times since 2018 (1.2 per year) source: EuropePMC
Clinical and experimental rheumatology, Volume 36 Suppl 113, Issue 4, 18 3 2018, Pages 109-117 To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis? Boonstra M, Mertens BJA, Bakker JA, Ninaber MK, Ajmone Marsan N, van der Helm-van Mil AHM, Scherer HU, Huizinga TWJ, de Vries-Bouwstra JK
Objectives: To evaluate the additive value of autoantibodies in identifying systemic sclerosis (SSc) patients with high complication risk. Methods: Patients entering the Combined Care In SSc cohort, Leiden University Medical Centre between April 2009 and May 2016 were included. Subgroups of patients were determined using hierarchical clustering, performed on Principal Component Analysis scores, 1) using baseline data of demographic and clinical variables only and 2) with additional use of antibo... Abstract
Cited 6 times since 2017 (0.9 per year) source: EuropePMC
Rheumatology international, Volume 38, Issue 3, 18 3 2017, Pages 443-453 Physical activity in patients with systemic sclerosis. Liem SIE, Meessen JMTA, Wolterbeek R, Ajmone Marsan N, Ninaber MK, Vliet Vlieland TPM, de Vries-Bouwstra JK
Objectives: To compare self-reported levels of physical activity (PA) of systemic sclerosis (SSc) patients with the general population. To evaluate in SSc patients factors associated with PA levels and needs and preferences regarding PA. Methods: Fifty nine SSc patients completed the Short QUestionnaire to ASsess Health-Enhancing PA. The proportion of patients meeting the Dutch Recommendation for PA (= moderate PA for 30 min on ≥ 5 days/week) and total minutes of PA per week were calculated and... Abstract
Cited 2 times since 2017 (0.3 per year) source: EuropePMC
Journal of thoracic imaging, Volume 32, Issue 6, 1 1 2017, Pages 391-397 Lung Density and Pulmonary Artery Diameter are Predictors of Pulmonary Hypertension in Systemic Sclerosis. Bakker ME, Ninaber MK, Stolk J, Kroft LJM, Schouffoer AA, de Vries Bouwstra JK, van Wijngaarden SE, Stoel BC
Purpose: The aim was to evaluate computed tomography (CT)-measured pulmonary artery diameter (PAD) and lung density as predictors of pulmonary hypertension (PH) in subjects with systemic sclerosis (SSc). We compared these PAD values with normal values and between SSc subgroups with PH and/or interstitial lung disease (ILD). We investigated whether PAD predicts PH and whether lung densitometry, by using the 85th percentile density value (Perc85) as a measure for ILD, can predict PH. Materials and... Abstract
Cited 26 times since 2017 (3.9 per year) source: EuropePMC
RMD open, Volume 3, Issue 2, 28 4 2017, Pages e000384 Rituximab in early systemic sclerosis. Boonstra M, Meijs J, Dorjée AL, Marsan NA, Schouffoer A, Ninaber MK, Quint KD, Bonte-Mineur F, Huizinga TWJ, Scherer HU, de Vries-Bouwstra JK
Objectives: (1) Hypothesis testing of the potency of rituximab (RTX) in preventing fibrotic complications and (2) assessing acceptability and feasibility of RTX in early systemic sclerosis (SSc). Methods: A small, 24-month, randomised, double-blind, placebo-controlled, single-centre trial in patients with SSc diagnosed Abstract
Cited 28 times since 2017 (4.1 per year) source: EuropePMC
Rheumatology (Oxford, England), Volume 56, Issue 7, 1 1 2017, Pages 1081-1088 Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy patterns and disease-specific autoantibodies. Markusse IM, Meijs J, de Boer B, Bakker JA, Schippers HPC, Schouffoer AA, Ajmone Marsan N, Kroft LJM, Ninaber MK, Huizinga TWJ, de Vries-Bouwstra JK
Objective: To evaluate the prevalence of anti-extractable nuclear antigen (anti-ENA) antibodies in Dutch SSc patients and the predictive power of the combination of specific anti-ENA antibodies and nailfold videocapillaroscopy (NVC) patterns to improve identification of patients with high risk for cardiopulmonary involvement. Methods: A total of 287 patients (79%) from the Leiden SSc-Cohort had data available on NVC-pattern (no SSc-specific, early, active, late) and anti-ENA antibodies. Associat... Abstract
Cited 12 times since 2016 (1.5 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 29, Issue 9, 19 3 2016, Pages 871-878 Prevalence and Correlates of Early Right Ventricular Dysfunction in Sarcoidosis and Its Association with Outcome. Joyce E, Kamperidis V, Ninaber MK, Katsanos S, Debonnaire P, Schalij MJ, Taube C, Bax JJ, Delgado V, Ajmone Marsan N
Background: Right ventricular (RV) function has not been systematically assessed in sarcoidosis. The aim of this study was to assess the prevalence and associates of RV dysfunction in sarcoidosis using global longitudinal peak systolic strain (GLS). Furthermore, whether RV dysfunction was associated with clinical outcomes was investigated. Methods: A total of 88 patients with sarcoidosis (mean age, 54 ± 13 years; 51% men) without known sarcoid-related or other structural heart disease or alterna... Abstract
Cited 29 times since 2016 (3.6 per year) source: EuropePMC
RMD open, Volume 2, Issue 1, 15 3 2016, Pages e000159 Therapeutic and diagnostic outcomes of a standardised, comprehensive care pathway for patients with systemic sclerosis. Meijs J, Schouffoer AA, Ajmone Marsan N, Kroft LJ, Stijnen T, Ninaber MK, Huizinga TW, Vliet Vlieland TP, de Vries-Bouwstra JK
Objectives: To determine the outcomes, including number of medical interventions and initiation of immunosuppressive treatment of a standardised, comprehensive, diagnostic care pathway for patients with systemic sclerosis (SSc). Patient characteristics associated with need for medical interventions and with need for immunosuppressive treatment were determined. Methods: Data were routinely gathered in connection with a 2-day care pathway combining multidisciplinary care and complete diagnostic wo... Abstract
Cited 3 times since 2015 (0.4 per year) source: EuropePMC
RMD open, Volume 1, Issue 1, 1 1 2015, Pages e000113 A prediction model for progressive disease in systemic sclerosis. Meijs J, Schouffoer AA, Ajmone Marsan N, Stijnen T, Putter H, Ninaber MK, Huizinga TW, de Vries-Bouwstra JK
Objective: To develop a model that assesses the risk for progressive disease in patients with systemic sclerosis (SSc) over the short term, in order to guide clinical management. Methods: Baseline characteristics and 1 year follow-up results of 163 patients with SSc referred to a multidisciplinary healthcare programme were evaluated. Progressive disease was defined as: death, ≥10% decrease in forced vital capacity, ≥15% decrease in diffusing capacity for carbon monoxide, ≥10% decrease in body we... Abstract