Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
55 results
The Lancet. Respiratory medicine, 16 3 2024, Pages S2213-2600(24)00074-2 Transbronchial cryobiopsy followed by as-needed surgical lung biopsy versus immediate surgical lung biopsy for diagnosing interstitial lung disease (the COLD study): a randomised controlled trial. Kalverda KA, Ninaber MK, Wijmans L, von der Thüsen J, Jonkers RE, Daniels JM, Miedema JR, Dickhoff C, Hölters J, Heineman D, Kant M, Radonic T, Shahin G, Cohen D, Boerrigter B, Nijman S, Nossent E, Braun J, Mathot B, Poletti V, Hetzel J, Dijkgraaf M, Korevaar DA, Bonta PI, Annema JT
Background: An adequate diagnosis for interstitial lung disease (ILD) is important for clinical decision making and prognosis. In most patients with ILD, an accurate diagnosis can be made by clinical and radiological data assessment, but in a considerable proportion of patients, a lung biopsy is required. Surgical lung biopsy (SLB) is the most common method to obtain tissue, but it is associated with high morbidity and even mortality. More recently, transbronchial cryobiopsy has been introduced,... Abstract
Lung cancer (Amsterdam, Netherlands), Volume 185, 17 3 2023, Pages 107362 Endobronchial ultrasound in diagnosing and staging of lung cancer by Acquire 22G TBNB versus regular 22G TBNA needles: A randomized clinical trial. Kramer T, Kuijvenhoven JC, von der Thüsen J, Cohen D, Szlubowski A, Gnass M, Ninaber MK, Hoppe B, Trisolini R, Sestakova Z, Votruba J, Korevaar DA, Bonta PI, Annema JT
Objectives: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has an important role in the diagnosis and staging of lung cancer. Evaluation of programmed death ligand 1 (PD-L1) expression and molecular profiling has become standard of care but cytological samples frequently contain insufficient tumor cells. The 22G Acquire needle with Franseen needle tip was developed to perform transbronchial needle biopsy (TBNB) with improved tissue specimens. This study evaluated if... Abstract
Cited 1 times since 2023 (1.5 per year) source: EuropePMC
BMC pulmonary medicine, Volume 23, Issue 1, 28 4 2023, Pages 314 The diagnostic accuracy of spirometry as screening tool for adult patients with a benign subglottic stenosis. Schuering JHC, Halperin IJY, Ninaber MK, Willems LNA, van Benthem PPG, Sjögren EV, Langeveld APM
Background: There is a considerable diagnostic delay in the diagnosis 'benign acquired subglottic stenosis in adults' (SGS, diagnosed by the reference standard, i.e. laryngo- or bronchoscopy). Patients are frequently misdiagnosed since symptoms of this rare disease may mimic symptoms of 'asthma.' The 'Expiratory Disproportion Index' (EDI) obtained by spirometry, may be a simple instrument to detect an SGS-patient. The aim of this study was to evaluate the diagnostic... Abstract
Cited 1 times since 2023 (1 per year) source: EuropePMC
Thrombosis research, Volume 226, 21 3 2023, Pages 51-55 Impact of pulmonary infarction in pulmonary embolism on presentation and outcomes. Kaptein FHJ, Kroft LJM, van Dam LF, Stöger JL, Ninaber MK, Huisman MV, Klok FA
Background: Pulmonary infarction (PI) is relatively common in pulmonary embolism (PE). The association between PI and persistent symptoms or adverse events is largely unknown. Aim: To evaluate the predictive value of radiological PI signs at acute PE diagnosis on 3-month outcomes. Methods: We studied a convenience cohort with computed tomography pulmonary angiography (CTPA)-confirmed PE for whom extensive 3-month follow-up data were available. The CTPAs were re-evaluated for signs of suspected P... Abstract
Cited 1 times since 2023 (1 per year) source: EuropePMC
The European respiratory journal, Volume 61, Issue 4, 20 3 2023, Pages 2300171 Chronic thromboembolic pulmonary hypertension and clot resolution after COVID-19-associated pulmonary embolism. de Jong CMM, Visser C, Bemelmans RHH, Boersma WG, van den Borst B, Burggraaf JLI, Cannegieter SC, Ten Cate-Hoek AJ, Croles FN, Faber HJ, Faber LM, Hellemons ME, Hessels LM, Huisman MV, Kamphuisen PW, Koster SCE, Kroft LJM, van der Lee I, Leentjens J, Meijer K, Ninaber MK, Sondermeijer BM, Stads S, Vonk Noordegraaf A, Winckers K, Kruip MJHA, Klok FA, Dutch COVID & Thrombosis Coalition investigators
Pulmonary circulation, Volume 13, Issue 2, 1 1 2023, Pages e12223 Automated quantification of the pulmonary vasculature in pulmonary embolism and chronic thromboembolic pulmonary hypertension. Zhai Z, Boon GJAM, Staring M, van Dam LF, Kroft LJM, Hernández Girón I, Ninaber MK, Bogaard HJ, Meijboom LJ, Vonk Noordegraaf A, Huisman MV, Klok FA, Stoel BC
The shape and distribution of vascular lesions in pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH) are different. We investigated whether automated quantification of pulmonary vascular morphology and densitometry in arteries and veins imaged by computed tomographic pulmonary angiography (CTPA) could distinguish PE from CTEPH. We analyzed CTPA images from a cohort of 16 PE patients, 6 CTEPH patients, and 15 controls. Pulmonary vessels were extracted with a graph-c... Abstract
RMD open, Volume 9, Issue 2, 1 1 2023, Pages e002971 Step forward in early recognition of systemic sclerosis: data from the Leiden CCISS cohort. Liem SIE, Ciaffi J, van Leeuwen NM, Boonstra M, Ahmed S, Beaart-van de Voorde LJJ, Corsel A, Dhondai T, Ninaber MK, Geelhoed-Veltman JJM, Heuvers ME, Tushuizen ME, Ajmone Marsan N, Kiès P, Schouffoer AA, Huizinga TWJ, Allaart CF, De Vries-Bouwstra J
Background: Since 2009, Dutch patients with a confirmed diagnosis/suspicion of systemic sclerosis (SSc) can be referred to the Leiden Combined Care in Systemic Sclerosis (CCISS) cohort. This study evaluated whether early recognition of SSc has improved over time and whether disease characteristics and survival has changed over time. Methods: 643 SSc patients fulfilling American College of Rheumatology/European Alliance of Associations for Rheumatology 2013 SSc criteria were included and categori... Abstract
Journal of scleroderma and related disorders, Volume 8, Issue 1, 5 1 2022, Pages 64-71 Mouth opening in systemic sclerosis: Its course over time, determinants and impact on mouth handicap. Khidir SJH, Boonstra M, Bergstra SA, Boerrigter GWM, Voogt-van der Harst EM, Ninaber MK, Ajmone Marsan N, Huizinga TWJ, van der Helm-van Mil AHM, de Vries-Bouwstra JK
Objective: Decreased maximal mouth opening is a common and disabling manifestation in systemic sclerosis patients. We aimed to study the course of maximal mouth opening, determinants of smaller maximal mouth opening over time and the burden of smaller maximal mouth opening on mouth handicap. Methods: Consecutive systemic sclerosis patients participating in the prospective Leiden Combined Care in systemic sclerosis cohort were included. Annual clinical assessment included maximal mouth opening me... Abstract
Cited 2 times since 2022 (1.1 per year) source: EuropePMC
Seminars in thrombosis and hemostasis, Volume 49, Issue 8, 12 2 2022, Pages 848-860 Post-Pulmonary Embolism Syndrome and Functional Outcomes after Acute Pulmonary Embolism. Luijten D, de Jong CMM, Ninaber MK, Spruit MA, Huisman MV, Klok FA
Survivors of acute pulmonary embolism (PE) are at risk of developing persistent, sometimes disabling symptoms of dyspnea and/or functional limitations despite adequate anticoagulant treatment, fulfilling the criteria of the post-PE syndrome (PPES). PPES includes chronic thromboembolic pulmonary hypertension (CTEPH), chronic thromboembolic pulmonary disease, post-PE cardiac impairment (characterized as persistent right ventricle impairment after PE), and post-PE functional impairment. To improve... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 166, 3 1 2022, Pages D6453 [A male with ossification of the lungs]. van Doorn-Hogervorst KMC, Ninaber MK
A 71-year old man, known with unclassified pulmonary fibrosis for years, shows dendriform pulmonary ossification (DPO) on a chest CT-scan after spontaneous pneumothorax. DPO is a rare finding with a mostly benign, slowly progressive course. Pneumothorax is an uncommon but clinically important complication of DPO with high chance of recurrence. Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
European heart journal. Case reports, Volume 6, Issue 2, 16 3 2022, Pages ytac067 Case report of the broad spectrum of late complications in an adult patient with univentricular physiology palliated by the Fontan circulation. Nederend M, Egorova AD, Vliegen HW, Roest AAW, Ruijter BN, Korteweg T, Ninaber MK, Zeppenfeld K, Hazekamp MG, Kiès P, Jongbloed MRM
Background: At the most severe end of the spectrum of congenital heart disease are patients with an univentricular physiology. They comprise a heterogeneous group of congenital heart malformations that have the common characteristic that the cardiac morphology is not equipped for sustaining a biventricular circulation. Case summary: Here, we present a case of an adult patient after Fontan palliation, illustrative of the complex clinical course and the broad spectrum of complications that can be... Abstract
Cited 10 times since 2022 (4.4 per year) source: EuropePMC
Arthritis care & research, Volume 74, Issue 3, 13 2 2022, Pages 433-441 Evolution of Systemic Sclerosis-Associated Interstitial Lung Disease One Year After Hematopoietic Stem Cell Transplantation or Cyclophosphamide. Ciaffi J, van Leeuwen NM, Boonstra M, Kroft LJM, Schouffoer AA, Ninaber MK, Huizinga TWJ, de Vries-Bouwstra JK
Objective: Hematopoietic stem cell transplantation (HSCT) and cyclophosphamide (CYC) are treatment options for progressive systemic sclerosis associated with interstitial lung disease (SSc-ILD). The aims of our retrospective observational study were to evaluate: 1) the evolution of SSc-ILD in SSc patients treated with HSCT (assessed by high-resolution computed tomography [HRCT]; a group of patients treated with CYC was included as frame of reference); 2) how results of pulmonary function tests (... Abstract
Cited 5 times since 2021 (2.1 per year) source: EuropePMC
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, Volume 27, Issue 8S, 1 1 2021, Pages S525-S529 Shrinking Lung Syndrome: Diagnostic and Therapeutic Challenges in 3 Patients With Systemic Lupus Erythematosus. Ciaffi J, Gegenava M, Ninaber MK, Huizinga TWJ
Cited 11 times since 2021 (4.5 per year) source: EuropePMC
Respirology (Carlton, Vic.), Volume 27, Issue 2, 17 3 2021, Pages 152-160 EBUS versus EUS-B for diagnosing sarcoidosis: The International Sarcoidosis Assessment (ISA) randomized clinical trial. Crombag LMM, Mooij-Kalverda K, Szlubowski A, Gnass M, Tournoy KG, Sun J, Oki M, Ninaber MK, Steinfort DP, Jennings BR, Liberman M, Bilaceroglu S, Bonta PI, Korevaar DA, Trisolini R, Annema JT
Background and objective: Endosonography with intrathoracic nodal sampling is proposed as the single test with the highest granuloma detection rate in suspected sarcoidosis stage I/II. However, most studies have been performed in limited geographical regions. Studies suggest that oesophageal endosonographic nodal sampling has higher diagnostic yield than endobronchial endosonographic nodal sampling, but a head-to-head comparison of both routes has never been performed. Methods: Global (14 hospit... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
BMJ open, Volume 11, Issue 9, 2 1 2021, Pages e051820 Endobronchial ultrasound in diagnosing and staging of lung cancer by Acquire 22G TBNB versus regular 22G TBNA needles: study protocol of a randomised clinical trial. Kuijvenhoven JC, Kramer T, Korevaar DA, Ninaber MK, Trisolini R, Szlubowski A, Gnass M, von der Thüsen J, Cohen D, Bonta PI, Annema JT
Introduction: Accurate diagnosis and staging of lung cancer is crucial because it directs treatment and prognosis. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound with bronchoscope fine-needle aspiration (EUS-B-FNA) are important in this process by sampling hilar/mediastinal lymph nodes and centrally located lung tumours. With the upcoming of immunotherapy and targeted therapies, assessment of programmed death ligand 1 (PD-L1) expression and... Abstract
Cited 8 times since 2021 (3 per year) source: EuropePMC
Thrombosis research, Volume 206, 17 3 2021, Pages 66-75 Efficacy and safety of a 12-week outpatient pulmonary rehabilitation program in Post-PE Syndrome. Boon GJAM, Janssen SMJ, Barco S, Bogaard HJ, Ghanima W, Kroft LJM, Meijboom LJ, Ninaber MK, Nossent EJ, Spruit MA, Symersky P, Vliegen HW, Noordegraaf AV, Huisman MV, Siegerink B, Abbink JJ, Klok FA
Background: The Post-Pulmonary Embolism Syndrome (PPES) comprises heterogeneous entities, including chronic thromboembolic disease with/without pulmonary hypertension (CTEPH/CTEPD), and deconditioning. Objectives: To assess underlying physiological determinants of PPES, and efficacy and safety of rehabilitation training in these patients. Methods: 56 consecutive PE patients with persistent dyspnea and/or functional limitations despite ≥3 months of anticoagulation underwent standardized diagnosti... Abstract
Cited 4 times since 2021 (1.3 per year) source: EuropePMC
Lupus science & medicine, Volume 8, Issue 1, 1 1 2021, Pages e000472 Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome. Wind M, Hendriks M, van Brussel BTJ, Eikenboom J, Allaart CF, Lamb HJ, Siebelink HJ, Ninaber MK, van Geloven N, van Lith JMM, Huizinga TWJ, Rabelink TJ, Sueters M, Teng YKO
Objectives: SLE and/or antiphospholipid syndrome (SLE/APS) are complex and rare systemic autoimmune diseases that predominantly affect women of childbearing age. Women with SLE/APS are at high risk of developing complications during pregnancy. Therefore, clinical practice guidelines recommend that patients with SLE/APS should receive multidisciplinary counselling before getting pregnant. We investigated the clinical effectiveness of implementing a multidisciplinary clinical pathway including pre... Abstract
Annals of the rheumatic diseases, Volume 80, Issue 10, 13 2 2021, Pages 1364-1365 Prospective study into COVID-19-like symptoms in patients with and without immune-mediated inflammatory diseases or immunomodulating drugs. van Ouwerkerk L, van der Meulen-de Jong AE, Ninaber MK, Teng YKO, Huizinga TW, Allaart CF
Cited 18 times since 2021 (5.9 per year) source: EuropePMC
Thrombosis research, Volume 202, 1 1 2021, Pages 162-169 Pulmonary infarction in acute pulmonary embolism. Kaptein FHJ, Kroft LJM, Hammerschlag G, Ninaber MK, Bauer MP, Huisman MV, Klok FA
Pulmonary infarction results from occlusion of the distal pulmonary arteries leading to ischemia, hemorrhage and ultimately necrosis of the lung parenchyma. It is most commonly caused by acute pulmonary embolism (PE), with a reported incidence of around 30%. Following an occlusion of the pulmonary artery, the bronchial arteries are recruited as primary source of perfusion of the pulmonary capillaries. The relatively higher blood pressure in the bronchial circulation causes an increase in the cap... Abstract
Cited 1 times since 2021 (0.3 per year) source: EuropePMC
TH open : companion journal to thrombosis and haemostasis, Volume 5, Issue 1, 1 1 2021, Pages e66-e72 Computed Tomography Pulmonary Perfusion for Prediction of Short-Term Clinical Outcome in Acute Pulmonary Embolism. van Dam LF, Kroft LJM, Huisman MV, Ninaber MK, Klok FA
Background Computed tomography pulmonary angiography (CTPA) is the imaging modality of choice for the diagnosis of acute pulmonary embolism (PE). With computed tomography pulmonary perfusion (CTPP) additional information on lung perfusion can be assessed, but its value in PE risk stratification is unknown. We aimed to evaluate the correlation between CTPP-assessed perfusion defect score (PDS) and clinical presentation and its predictive value for adverse short-term outcome of acute PE. Patients... Abstract