Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
90 results
JACC. Case reports, Volume 3, Issue 2, 17 3 2021, Pages 217-219 Björk-Fontan and the Restoration of Right-Sided Conduits. de Winter RJ, Koolbergen DR
Cited 7 times since 2021 (2.2 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 54, Issue 2, 10 2 2021, Pages 411-420 Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy. Bakermans AJ, Boekholdt SM, de Vries DK, Reckman YJ, Farag ES, de Heer P, Uthman L, Denis SW, Zuurbier CJ, Houtkooper RH, Koolbergen DR, Kluin J, Planken RN, Lamb HJ, Webb AG, Strijkers GJ, Beard DA, Jeneson JAL, Nederveen AJ
Background: Proton magnetic resonance spectroscopy (1 H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. Purpose: To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized 1 H-MRS. Study type: Test-retest repeatability and measurement validation study. Subjects: Sixteen v... Abstract
EClinicalMedicine, Volume 31, 23 4 2020, Pages 100661 Continuous postoperative pericardial flushing reduces postoperative bleeding after coronary artery bypass grafting: A randomized trial. Diephuis EC, de Borgie CA, Zwinderman A, Winkelman JA, van Boven WP, Henriques JPS, Eberl S, Juffermans NP, Schultz MJ, Klautz RJM, Koolbergen DR
Background: Prolonged or excessive bleeding after cardiac surgery can lead to a broad spectrum of secondary complications. One of the underlying causes is incomplete wound drainage, with subsequent accumulation of blood and clots in the pericardium. We developed the continuous postoperative pericardial flushing (CPPF) therapy to improve wound drainage and reduce postoperative blood loss and bleeding-related complications after cardiac surgery. This study compared CPPF to standard care in patient... Abstract
Cited 14 times since 2020 (3.9 per year) source: EuropePMC
The Journal of experimental medicine, Volume 217, Issue 10, 1 1 2020, Pages e20200318 Liver X receptors are required for thymic resilience and T cell output. Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and function. LXRαβ-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXRαβ's functions are cell specific, and the resulting phen... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Volume 73, Issue 7, 16 3 2020, Pages 1357-1404 Influence of age on scar tissue: A retrospective study on the differences in scar tissue development between children and adults. van de Kar AL, van Riessen F, Koolbergen DR, van der Horst CMAM
Cited 25 times since 2019 (5.3 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 39, Issue 9, 18 3 2019, Pages 1859-1873 Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients. Yin 殷晓科 X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M
Objective: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matrix (ECM) component, which is modified post-translationally by glycosylation. This study aimed to characterize the glycoproteome of the aortic ECM from patients with MFS and relate it to aortopathy. Approach and Results: ECM extracts of aneurysmal ascending aortic tissue from patients with and without MFS were enriched for glycopeptides. Direct N-glycopeptide analysis by mass spectrometry identifie... Abstract
Cited 14 times since 2019 (2.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 22, 10 2 2019, Pages 1732-1740 Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation. van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA
Objective: To study neo-aortic growth and the evolution of neo-aortic valve regurgitation (AR) in patients with transposition of the great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood and to identify patients at risk. Methods: Neo-aortic dimensions (annulus/root/sinotubular junction) and neo-aortic valve regurgitation were assessed serially in 345 patients with TGA who underwent ASO between 1977 and 2015. Linear mixed-effect models were used to assess increase o... Abstract
Cited 3 times since 2019 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 20, Issue 2, 1 1 2019, Pages 225-232 Predictors of residual tricuspid regurgitation after percutaneous closure of atrial septal defect. Nassif M, van der Kley F, Abdelghani M, Kalkman DN, de Bruin-Bon RHACM, Bouma BJ, Schalij MJ, Koolbergen DR, Tijssen JGP, Mulder BJM, de Winter RJ
Aims: Functional tricuspid regurgitation (TR) associated with atrial septal defects (ASDs) is frequently present due to right-sided volume-overload. Tricuspid valve (TV) repair is often considered in candidates for surgical ASD closure, and percutaneous TV repair is currently under clinical investigation. In this study, we develop a prediction model to identify patients with residual moderate/severe TR after percutaneous ASD closure. Methods and results: In this observational study, 172 adult pa... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 55, Issue 2, 1 1 2019, Pages 331-337 Aortic coarctation repair through left thoracotomy: results in the modern era. Farag ES, Kluin J, de Heer F, Ahmed Y, Sojak V, Koolbergen DR, Blom NA, de Mol BAJM, Ten Harkel ADJ, Hazekamp MG
Objectives: Surgical repair of coarctation of the aorta (CoA) is often possible through left thoracotomy and without the use of cardiopulmonary bypass. Recent studies reporting the outcome after CoA repair through left thoracotomy are limited. Therefore, the aim of this study is to evaluate the results of CoA repair through left thoracotomy in children who were operated on in our centre over the past 21 years. Methods: From January 1995 to December 2016, 292 patients younger than 18 years underw... Abstract
Cited 8 times since 2019 (1.5 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 28, Issue 2, 1 1 2019, Pages 279-283 Excellent durability of homografts in pulmonary position analysed in a predefined adult group with tetralogy of Fallot. Meijer FMM, Kies P, Jongbloed MRM, Hazekamp MG, Koolbergen DR, Blom NA, de Roos A, Schalij MJ, Vliegen HW
Objectives: In repaired tetralogy of Fallot, surgical pulmonary valve replacement (PVR) is in certain cases required. Our institution reported earlier about 26 patients who received a pulmonary homograft via PVR. To date, we have data from more than 17 years of follow-up. The aim of this retrospective study was to evaluate the late haemodynamic and clinical outcomes in this predefined patient group. Methods: Between 1993 and 2001, 26 patients underwent PVR for pulmonary regurgitation (58% men; 3... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
The Journal of cardiovascular surgery, Volume 60, Issue 1, 1 1 2019, Pages 152-154 Abnormal blood flow and wall shear stress are present in corrected aortic coarctation despite successful surgical repair. Farag ES, van Ooij P, Boekholdt SM, Planken RN, Dukker KC, Bouma BJ, Groenink M, Koolbergen DR, Sojak V, Nederveen AJ, Hazekamp MG, de Mol BA, Kluin J
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
Journal of plastic surgery and hand surgery, Volume 53, Issue 3, 27 4 2019, Pages 161-166 Comparison of wound closure techniques in median sternotomy scars in children: subcuticular suture versus Steri-Strip™ S. van de Kar AL, Koolbergen DR, van Avendonk JPH, van der Horst CMAM
Objectives: The aim of this retrospective study was to compare subcuticular sutures and Steri-Strip™ S in closing median sternotomy incisions in children with regard to wound healing and scar formation. Methods: Fifty-three children and adolescents were enrolled in this study who all underwent a median sternotomy at age 0-18 years and had their presternal cutaneous wounds closed with either a running subcuticular suture (Group 1) or Steri-Strip™ S (Group 2). Their scars were assessed using the P... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
International journal of cardiology, Volume 274, 12 2 2018, Pages 113-116 Aortic dissection and prophylactic surgery in congenital heart disease. Kuijpers JM, Koolbergen DR, Groenink M, Boekholdt SM, Meijboom FJ, Jongbloed MRM, Hoendermis ES, Duijnhouwer AL, Mulder BJM, Bouma BJ
Background: Proximal aortic dilatation in certain congenital heart diseases (CHD) prompts concerns about dissection and consideration of prophylactic surgery. To evaluate contemporary prophylactic practice, we determined incidence of aortic dissection and prophylactic surgery in aortopathy-associated CHD, compared to Marfan syndrom (MFS) and controls. Methods and results: We followed patients from the CONCOR adult CHD registry (2002-2015), with a native proximal aorta and aortopathy-associated C... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
European heart journal. Case reports, Volume 2, Issue 3, 2 1 2018, Pages yty090 Rupture of a giant aneurysm of the sinus of Valsalva leading to acute heart failure: a case report demonstrating the excellence of echocardiography. Wierda E, Koolbergen DR, de Mol BAJM, Bouma BJ
Cited 22 times since 2018 (3.8 per year) source: EuropePMC
Journal of the American Heart Association, Volume 7, Issue 13, 22 4 2018, Pages e008163 Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review. Abdelghani M, Nassif M, Blom NA, Van Mourik MS, Straver B, Koolbergen DR, Kluin J, Tijssen JG, Mulder BJM, Bouma BJ, de Winter RJ
Background: Infective endocarditis (IE) after transcatheter pulmonary valve implantation (TPVI) in dysfunctioning right ventricular outflow tract conduits has evoked growing concerns. We aimed to investigate the incidence and the natural history of IE after TPVI with the Melody valve through a systematic review of published data. Methods and results: PubMed, EMBASE, and Web of Science databases were systematically searched for articles published until March 2017, reporting on IE after TPVI with... Abstract
Cited 1 times since 2017 (0.2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 52, Issue 6, 1 1 2017, Pages 1155-1160 Fifteen years' experience with the use of artificial chords for valve reconstruction in children. Kluin J, Sojak V, Koolbergen DR, Boon R, Bökenkamp R, Hazekamp MG
Objectives: To retrospectively review our experience with artificial chords in mitral and tricuspid reconstructive surgery in children. Methods: All consecutive paediatric ( Abstract
Cited 3 times since 2017 (0.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 104, Issue 6, 16 3 2017, Pages 454-455 Surgical treatment of Marfan syndrome and related disorders is all about dealing with uncertainties. Groenink M, Koolbergen DR
Cited 33 times since 2017 (4.9 per year) source: EuropePMC
European heart journal, Volume 38, Issue 26, 1 1 2017, Pages 2048-2056 Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. Kuijpers JM, Koolbergen DR, Groenink M, Peels KCH, Reichert CLA, Post MC, Bosker HA, Wajon EMCJ, Zwinderman AH, Mulder BJM, Bouma BJ
Aims: Adult congenital heart disease (ACHD) predisposes to infective endocarditis (IE). Surgical advancements have changed the ACHD population, whereas associated prosthetic material may constitute additional IE targets. We aimed to prospectively determine contemporary incidence, risk factors, and predictors of IE in a nationwide ACHD cohort, focusing on the presence of prosthetics. Methods and results: We identified 14 224 patients prospectively followed in the CONCOR ACHD registry (50.5% femal... Abstract
Cited 29 times since 2017 (4.1 per year) source: EuropePMC
Circulation. Cardiovascular quality and outcomes, Volume 10, Issue 2, 22 4 2017, Pages e003178 Does the Use of a Decision Aid Improve Decision Making in Prosthetic Heart Valve Selection? A Multicenter Randomized Trial. Korteland NM, Ahmed Y, Koolbergen DR, Brouwer M, de Heer F, Kluin J, Bruggemans EF, Klautz RJ, Stiggelbout AM, Bucx JJ, Roos-Hesselink JW, Polak P, Markou T, van den Broek I, Ligthart R, Bogers AJ, Takkenberg JJ
Background: A Dutch online patient decision aid to support prosthetic heart valve selection was recently developed. A multicenter randomized controlled trial was conducted to assess whether use of the patient decision aid results in optimization of shared decision making in prosthetic heart valve selection. Methods and results: In a 5-center randomized controlled trial, patients were allocated to receive either standard preoperative care (control group) or additional access to the patient decisi... Abstract
Cited 163 times since 2016 (21.2 per year) source: EuropePMC
Circulation research, Volume 119, Issue 9, 16 3 2016, Pages 996-1003 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM
Rationale: RNA-binding motif protein 20 (RBM20) is essential for normal splicing of many cardiac genes, and loss of RBM20 causes dilated cardiomyopathy. Given its role in splicing, we hypothesized an important role for RBM20 in forming circular RNAs (circRNAs), a novel class of noncoding RNA molecules. Objective: To establish the role of RBM20 in the formation of circRNAs in the heart. Methods and results: Here, we performed circRNA profiling on ribosomal depleted RNA from human hearts and ident... Abstract