Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
90 results
Vascular pharmacology, Volume 154, 23 4 2024, Pages 107279 Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells. Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V
The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction is a key-characteristic of clinical AAA disease. We hypothesize that doxycycline impairs mitochondrial function in the aorta and aortic smooth muscle cells (SMCs). Doxycycline induced mitonuclear imbalance, reduced proliferation and diminished expression of typical contractile smooth muscle cell (SMC) proteins.... Abstract
Cited 1 times since 2023 (2.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 64, Issue 5, 1 1 2023, Pages ezad291 Aortic valve visualization and pressurization device: a novel device for intraoperative evaluation of aortic valve repair procedures. Arabkhani B, Sandker SC, Braun J, Hjortnaes J, van Brakel TJ, Koolbergen DR, Klautz RJM, Hazekamp MG
Objectives: Aortic valve repair procedures are technically challenging, and current intraoperative evaluation methods often fail to predict the final echocardiographic result. We have developed a novel intraoperative aortic valve visualization and pressurization (AVP) device, enabling valve inspection under physiological conditions, and measuring aortic valve insufficiency (AI) during cardioplegic arrest. Methods: The AVP device is attached to the (neo)aorta, after any type of aortic valve repai... Abstract
Journal of clinical medicine, Volume 12, Issue 14, 20 3 2023, Pages 4798 Catheter-Based Techniques for Addressing Atrioventricular Valve Regurgitation in Adult Congenital Heart Disease Patients: A Descriptive Cohort. El Bouziani A, Witte LS, Bouma BJ, Jongbloed MRM, Robbers-Visser D, Straver B, Beijk MAM, Kiès P, Koolbergen DR, van der Kley F, Schalij MJ, de Winter RJ, Egorova AD
Introduction: Increasing survival of adult congenital heart disease (ACHD) patients comes at the price of a range of late complications-arrhythmias, heart failure, and valvular dysfunction. Transcatheter valve interventions have become a legitimate alternative to conventional surgical treatment in selected acquired heart disease patients. However, literature on technical aspects, hemodynamic effects, and clinical outcomes of percutaneous atrioventricular (AV) valve interventions in ACHD patients... Abstract
CJC pediatric and congenital heart disease, Volume 2, Issue 3, 8 2 2023, Pages 124-133 Anomalous Aortic Origin of the Right Coronary Artery: Invasive Haemodynamic Assessment in Adult Patients With High-Risk Anatomic Features. Verheijen DBH, Egorova AD, Jongbloed MRM, van der Kley F, Koolbergen DR, Hazekamp MG, Lamb HJ, Jukema JW, Kiès P, Vliegen HW
Background: Anomalous aortic origin of a right coronary artery (AAORCA) with an interarterial course merits further evaluation; however, robust risk assessment strategies for myocardial ischemia and sudden cardiac death are currently lacking. The aim of this study is to explore the potential role of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and intravascular ultrasound (IVUS) in patients with AAORCA. Methods: Consecutive adult patients with AAORCA with an interarterial... Abstract
Cited 1 times since 2023 (0.9 per year) source: EuropePMC
Magma (New York, N.Y.), Volume 36, Issue 5, 23 4 2023, Pages 701-709 A comparison of myocardial magnetic resonance extracellular volume mapping at 3 T against histology of tissue collagen in severe aortic valve stenosis and obstructive hypertrophic cardiomyopathy. Bakermans AJ, Kouwenhoven M, de Vos J, de Vries DK, Reckman YJ, Farag ES, Koolbergen DR, Kluin J, Nederveen AJ, Strijkers GJ, Boekholdt SM
Objective: Quantitative extracellular volume fraction (ECV) mapping with MRI is commonly used to investigate in vivo diffuse myocardial fibrosis. This study aimed to validate ECV measurements against ex vivo histology of myocardial tissue samples from patients with aortic valve stenosis or hypertrophic cardiomyopathy. Materials and methods: Sixteen patients underwent MRI examination at 3 T to acquire native T1 maps and post-contrast T1 maps after gadobutrol administration, from which hematocrit-... Abstract
Prenatal diagnosis, Volume 43, Issue 5, 17 3 2023, Pages 629-638 Short-term outcome after the prenatal diagnosis of right aortic arch. Bet BB, Snoep MC, van Leeuwen E, Linskens IH, Haak MC, Rozendaal L, Knobbe I, van Schuppen J, Hoekstra CEL, Koolbergen DR, Clur SA, Pajkrt E
Objectives: To determine the proportion of children that require surgery in the first year of life and thereafter in order to improve the counseling of parents with a fetus with a right aortic arch (RAA). Methods: Fetuses diagnosed with isolated RAA, defined as the absence of intra- or extracardiac anomalies, between 2007 and 2021 were extracted from the prospective registry PRECOR. Results: In total, 110 fetuses were included, 92 with a prenatal diagnosis of RAA and 18 with double aortic arch (... Abstract
Cited 7 times since 2023 (5.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 2, 1 1 2023, Pages ezac514 A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database. Arabkhani B, Klautz RJM, de Heer F, De Kerchove L, El Khoury G, Lansac E, Schäfers HJ, El-Hamamsy I, Lenoir M, Aramendi JI, Meuris B, Verbrugghe P, Kluin J, Koolbergen DR, Bouchot O, Rudez I, Kolesar A, van Brakel TJ
Objectives: Our goal was to evaluate the outcome of valve-sparing root replacement (VSRR) and to compare the outcomes to those of patients having composite valve-graft conduit aortic root replacement (CVG-ARR) in a cohort of patients with aortic root aneurysm ± valve insufficiency, without valvular stenosis. Although valve-sparing procedures are preferable in young patients, there is a lack of comparative data in comparable patients. Methods: The VSRR procedures were performed in 2005 patients,... Abstract
Cited 1 times since 2023 (0.8 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 12 2 2023, Pages 1036522 Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy. Dolmaci OB, Ayyildiz T, Poelmann RE, Driessen AHG, Koolbergen DR, Klautz RJM, Lindeman JHN, Grewal N
Objective: Patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic complications. Bicuspidy is known to have a low risk for acquired coronary artery sclerosis. The aim of this study is to determine the risk of coronary sclerosis in MFS patients. Methods: Marfan syndrome patients with an aortic root dilatation, which were surgic... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Vascular biology (Bristol, England), Volume 4, Issue 1, 30 5 2022, Pages 40-49 No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice. Hibender S, Li S, Postma AV, Hoogeland ME, Klaver D, Pouw RB, Niessen HW, Driessen AH, Koolbergen DR, de Vries CJ, Baars MJ, Houweling AC, Krijnen PA, de Waard V
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture. Upon whole genome sequencing of a Marfan family, we identified a complement gene C1R variant (p.Ser152Leu), which is associated with severe aortic patients. Therefore, we assessed the role of complement activation in MFS aortic tissue. Expression of various complement genes and pr... Abstract
Cited 3 times since 2022 (1.8 per year) source: EuropePMC
European heart journal. Case reports, Volume 6, Issue 8, 16 3 2022, Pages ytac345 Anomalous coronary artery from the pulmonary artery diagnosed in adulthood: a case series on variations of coronary anatomy and the diagnostic value of cardiac magnetic resonance imaging. Talebian Yazdi M, Robbers-Visser D, van der Bilt IAC, Boekholdt SM, Koolbergen DR, Planken RN, Groenink M
Background: Anomalous coronary artery from the pulmonary artery is a rare congenital disorder with high mortality rates in infancy. Adult cases can present with life-threatening arrhythmias and sudden cardiac death. Case summary: We report three cases of adults with anomalous pulmonary origin of each of the main coronary branches. The first patient with an anomalous left coronary artery from the pulmonary artery presented with an out-of-hospital cardiac arrest. The second patient with an anomalo... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac240 Mechanical circulatory support in the failing systemic right ventricle: a step towards better outcome. Koolbergen DR
Cited 2 times since 2022 (1 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 10 2 2022, Pages 870459 Atrioventricular Block Necessitating Chronic Ventricular Pacing After Tricuspid Valve Surgery in Patients With a Systemic Right Ventricle: Long-Term Follow-Up. Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Regeer MV, Koolbergen DR, Hazekamp MG, Schalij MJ, Egorova AD
Background: Patients with transposition of the great arteries (TGA) after an atrial switch or congenitally corrected TGA (ccTGA) are prone to systemic right ventricular (sRV) failure. Tricuspid valve (TV) regurgitation aggravates sRV dysfunction. Timely TV surgery stabilizes sRV function, yet the development of atrioventricular (AV)-conduction disturbances in the course of sRV failure can contribute to sRV dysfunction through pacing-induced dyssynchrony. This study aims to explore the incidence,... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 132, Issue 6, 5 1 2022, Pages 1560-1568 Cerebral hemodynamics during sustained intraoperative hypotension. Kho E, Sperna Weiland NH, Vlaar APJ, Veelo DP, van der Ster BJP, Corsmit OT, Koolbergen DR, Dilai J, Immink RV
Static cerebral autoregulation (CA) maintains cerebral blood flow (CBF) relatively constant above a mean arterial blood pressure (BPmean) of 60-65 mmHg. Below this lower limit of CA (LLCA), CBF declines along with BPmean. Data are lacking in describing how CA reacts to sustained hypotension since hypotension is usually avoided. In this study, we took advantage of a procedure requiring sustained hypotension. We assessed static CA for LLCA determination, and a more continuous CA, which counters sh... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
European heart journal open, Volume 2, Issue 4, 2 1 2022, Pages oeac031 A comprehensive analysis of the intramural segment in interarterial anomalous coronary arteries using computed tomography angiography. Koppel CJ, Verheijen DBH, Kiès P, Egorova AD, Lamb HJ, Voskuil M, Jukema JW, Koolbergen DR, Hazekamp MG, Schalij MJ, Jongbloed MRM, Vliegen HW
Aims: An anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS) with an interarterial course can be assessed using computed tomography angiography (CTA) for the presence of high-risk characteristics associated with sudden cardiac death. These features include a slit-like ostium, acute angle take-off, proximal luminal narrowing, and an intramural segment. To date, no robust CTA criteria exist to determine the presence of an intramural segment. We aimed to deduct new CTA... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
BMC pediatrics, Volume 22, Issue 1, 12 2 2022, Pages 85 Myocardial infarction due to thrombotic occlusion despite anticoagulation in Kawasaki disease - a case report. van Stijn D, Schoenmaker NJ, Planken RN, Koolbergen DR, Gouw SC, Kuijpers TW, Blom NA, Kuipers IM
Background: Kawasaki disease (KD) is a pediatric vasculitis. Mainly the coronary arteries become affected due to acute inflammation and formation of coronary artery aneurysms (CAAs) can occur. The larger the CAA, the higher the risk for clinical complications and major adverse cardiac events, as the blood flow changes to vortex or turbulent flow facilitating thrombosis. Such patients may develop life threatening thrombotic coronary artery occlusion and myocardial ischemiaunless anti-platelet and... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
JACC. Case reports, Volume 3, Issue 14, 20 3 2021, Pages 1589-1593 Closing a Right Coronary Artery Fistula Draining Into the Coronary Sinus Using a Covered Stent in the Coronary Sinus. Witte LS, Bouma BJ, Straver B, van der Lienden BTG, Kist R, Blom NA, Koolbergen DR, de Winter RJ
This report describes the case of a symptomatic patient with a right coronary artery fistula draining into the coronary sinus who underwent transcatheter closure, which was deployed in the drainage site to seal off the exit of the fistula. (Level of Difficulty: Advanced.). Abstract
Interactive cardiovascular and thoracic surgery, Volume 33, Issue 3, 1 1 2021, Pages 462-468 A modified surgical technique for aortopexy in tracheobronchomalacia. Dolmaci OB, Fockens MM, Oomen MW, van Woensel JB, Hoekstra CEL, Koolbergen DR
Objectives: Tracheobronchomalacia (TBM) is characterized by collapse of trachea, bronchi or both, leading to dyspnoea, expiratory stridor, coughing or recurrent airway infections. Surgical treatment with aortopexy is warranted for severe TBM. We describe a modified aortopexy technique with aortic wall strap sutures that evenly distributes the traction force over the full width of the aortic arch. The aim of this study was to determine the outcomes of this modified anterior aortopexy technique. M... Abstract
Cited 10 times since 2021 (3.3 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 59, Issue 5, 1 1 2021, Pages 968-977 Long-term outcome after the arterial switch operation: 43 years of experience. van der Palen RLF, Blom NA, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Konings TC, Bouma BJ, Koolbergen DR, Hazekamp MG
Objectives: The objective of this study was to assess our 43-year experience with arterial switch operation (ASO) for transposition of the great arteries (TGA) by analysing cardiac outcome measures (hospital and late mortality, reoperations and catheter interventions, significant coronary artery obstruction) and to identify risk factors for reoperation and catheter interventions. Methods: A total of 490 patients who underwent ASO for TGA from 1977 to 2020 were included in this retrospective, sin... Abstract
Circulation. Cardiovascular imaging, Volume 14, Issue 4, 2 1 2021, Pages e011688 Multimodality Evaluation of a Septal Cystic Cavity and Ventricular Septal Defect in the Setting of Neurocysticercosis and Endocarditis. Schuuring MJ, van der Bom T, Konings TC, Götte MJW, Koolbergen DR, Boekholdt SM, de Winter RJ
Cited 7 times since 2021 (2.2 per year) source: EuropePMC
Journal of cardiovascular development and disease, Volume 8, Issue 3, 26 4 2021, Pages 25 The Clinical Spectrum of Kommerell's Diverticulum in Adults with a Right-Sided Aortic Arch: A Case Series and Literature Overview. van Rosendael PJ, Stöger JL, Kiès P, Vliegen HW, Hazekamp MG, Koolbergen DR, Lamb HJ, Jongbloed MRM, Egorova AD
Background: Kommerell's diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of an aberrant subclavian artery. In the variant of a right-sided aortic arch, the trachea and esophagus are enclosed dorsally by the arch. In the configuration of an aberrant left subclavian artery, a Kommerell's diverticulum and persisting ductus arteriosus or ductal ligament enclose the lateral side, forming a vascular ring which may result in (symptomatic) esophageal or trachea... Abstract