Research

Publications

Below you can find a list of our published research.

158 results

Cited 1 times since 2016 (0.2 per year) source: Scopus

The American Journal of Cardiology, Volume 117, Issue 7, 02 February 2016, Pages 1167-1172 Comparison of Left Ventricular Volume and Ejection Fraction and Frequency and Extent of Aortic Regurgitation After Operative Repair of Type A Aortic Dissection Among Three Different Surgical Techniques. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Differences in recurrence rate of aortic regurgitation (AR) and extent of left ventricular (LV) remodeling across the different surgical options in patients operated for type A aortic dissection remain unknown. The present evaluation compared the AR recurrence rate and changes in LV volumes and systolic function in valve-sparing aorta replacement (VSAR), supracoronary ascending aorta replacement (SCAR), and aortic valve and aorta replacement (AVAR). A total of 97 patients (58 ± 12 years, 62% me... Abstract

Cited 9 times since 2016 (1.9 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 01 February 2016, Pages 127-133 The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation. Koenraadt WM, Grewal N, Gaidoukevitch OY, DeRuiter MC, Gittenberger-de Groot AC, Bartelings MM, Holman ER, Klautz RJ, Schalij MJ, Jongbloed MR

The clinical course of bicuspid aortic valves (BAVs) is variable. Data on predictors of aortopathy and valvular dysfunction mainly focus on valve morphology.To determine whether the presence and extent of the raphe (fusion site of valve leaflets) is associated with the degree of aortopathy and valvular dysfunction in patients with isolated BAV and associated aortic coarctation (CoA).Valve morphology and aortic dimensions of 255 BAV patients were evaluated retrospectively by echocardiography.BAVs... Abstract

Cited 4 times since 2016 (0.9 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 01 February 2016, Pages 143-151 Outcome of stand-alone thoracoscopic epicardial left atrial posterior box isolation with bipolar radiofrequency energy for longstanding persistent atrial fibrillation. Compier MG, Braun J, Tjon A, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA

Catheter ablation of longstanding (> 1 year) persistent atrial fibrillation (AF) is associated with poor outcome. This might be due to remodelling and fibrosis formation, mainly located in the posterior left atrial (LA) wall. Therefore, we adopted a thoracoscopic epicardial box isolation of the posterior left atrium using bipolar RF energy with intraoperative testing of conduction block.Bilateral thoracoscopic box isolation was performed with a bipolar RF clamp. Entrance block was defined as a... Abstract

Cited 18 times since 2016 (3.8 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 6, 19 January 2016, Pages 1699-1704 Stentless bioprostheses: a versatile and durable solution in extensive aortic valve endocarditis. Schneider AW, Hazekamp MG, Versteegh MI, Bruggemans EF, Holman ER, Klautz RJ, Braun J

Infective endocarditis of the aortic valve with local aortic root destruction requires radical resection of infected tissues and subsequent reconstruction of periannular structures and the left ventricular outflow tract (LVOT). Homografts or stentless bioprostheses are recommended for use in this specific patient group. The Freestyle stentless bioprosthesis is a porcine aortic root prosthesis, which approaches the surgical versatility of the homograft, but has the advantage of ready availability... Abstract

Cited 2 times since 2015 (0.4 per year) source: EuropePMC

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Volume 26, Issue 6, 01 September 2015, Pages 613-620 Fibrinogen reduction and coagulation in cardiac surgery: an investigational study. Gielen CL, Grimbergen J, Klautz RJ, Koopman J, Quax PH

Fibrinogen as precursor of fibrin plays an essential role in clot formation. There are three main mechanisms associated with a reduction in fibrinogen concentration during cardiac surgery: hemodilution, consumption, and degradation. Moreover, early fibrinogen degradation products (FgDPs) can interfere with normal fibrin formation of intact fibrinogen. The aim of this study was to determine the relative contributions of hemodilution, consumption, and degradation to fibrinogen loss in cardiac surg... Abstract

Cited 6 times since 2015 (1.2 per year) source: Scopus

The British journal of surgery, Volume 102, Issue 11, 12 August 2015, Pages 1338-1347 Multicentre randomized clinical trial to investigate the cost-effectiveness of an allogeneic single-donor fibrin sealant after coronary artery bypass grafting (FIBER Study). Tavilla G, Bruggemans EF, Gielen CL, Brand A, van den Hout WB, Klautz RJ, van Hilten JA

Reduction of blood transfusion in cardiac surgery is an important target. The aim of this study was to investigate the cost-effectiveness of the use of CryoSeal®, an allogeneic single-donor fibrin sealant, in patients undergoing coronary artery bypass grafting (CABG).This randomized clinical study involved seven cardiac surgery centres in the Netherlands. Patients undergoing elective isolated CABG with the use of at least one internal thoracic artery (ITA) graft were assigned randomly to receiv... Abstract

Cited 5 times since 2015 (1 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 48, Issue 4, 06 August 2015, Pages e64-70 Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding? Gielen CL, Bruggemans EF, Stijnen T, Eikenboom J, Tavilla G, Brand A, Klautz RJ

As the indication for antiplatelet medication expands, patients may be exposed to an increased risk of excessive blood loss when cardiac surgery is required. The optimal timing to stop acetylsalicylic acid (ASA) or ASA combined with clopidogrel (ASA+Clo) before surgery is the subject of controversy.A total of 1065 patients were selected from a prospective randomized study on the effect of a fibrin sealant application in coronary artery bypass graft surgery [Fibrin sealant Induced Blood Exposure... Abstract

Cited 3 times since 2015 (0.6 per year) source: Scopus

EBioMedicine, Volume 2, Issue 9, 31 July 2015, Pages 1217-1223 Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss. Manshanden JS, Gielen CL, de Borgie CA, Klautz RJ, de Mol BA, Koolbergen DR

Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative pericardial flushing (CPPF) with an irrigation solution may reduce blood loss by preventing the accumulation of clots. In this pilot study, the safety and feasibility of CPPF were evaluated and the effect on blood loss... Abstract

Cited 1 times since 2015 (0.2 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 21, Issue 4, 09 July 2015, Pages 459-464 Transthoracic echocardiography for selection of tubular graft size in David reimplantation technique. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Selection of tubular graft size during David reimplantation technique for aortic root dilatation is based on perioperative leaflet height measurements. The present study evaluated whether transthoracic echocardiography (TTE)-based algorithms may help in selecting the graft size preoperatively.Thirty patients (52 ± 11 years old, 73% men) who underwent David reimplantation technique were evaluated. The implanted graft size was based on the David's formula. Leaflet height [diameter = 1.1 × ((2 ×... Abstract

Cited 3 times since 2015 (0.6 per year) source: Scopus

Cardiovascular research, Volume 107, Issue 4, 03 July 2015, Pages 601-612 Forced fusion of human ventricular scar cells with cardiomyocytes suppresses arrhythmogenicity in a co-culture model. Engels MC, Askar SF, Jangsangthong W, Bingen BO, Feola I, Liu J, Majumder R, Versteegh MI, Braun J, Klautz RJ, Ypey DL, De Vries AA, Pijnappels DA

Fibrosis increases arrhythmogenicity in myocardial tissue by causing structural and functional disruptions in the cardiac syncytium. Forced fusion of fibroblastic cells with adjacent cardiomyocytes may theoretically resolve these disruptions. Therefore, the electrophysiological effects of such electrical and structural integration of fibroblastic cells into a cardiac syncytium were studied.Human ventricular scar cells (hVSCs) were transduced with lentiviral vectors encoding enhanced green fluore... Abstract

Cited 20 times since 2015 (3.8 per year) source: Scopus

Heart and vessels, Volume 31, Issue 5, 01 July 2015, Pages 795-806 Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? Grewal N, Franken R, Mulder BJ, Goumans MJ, Lindeman JH, Jongbloed MR, DeRuiter MC, Klautz RJ, Bogers AJ, Poelmann RE, Groot AC

Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic... Abstract

Cited 12 times since 2015 (2.2 per year) source: EuropePMC

Open heart, Volume 2, Issue 1, 08 April 2015, Pages e000237 Prosthetic aortic valve selection: current patient experience, preferences and knowledge. Korteland NM, Bras FJ, van Hout FM, Kluin J, Klautz RJ, Bogers AJ, Takkenberg JJ

OBJECTIVE:Current clinical practice guidelines advocate shared decision-making (SDM) in prosthetic valve selection. This study assesses among adult patients accepted for aortic valve replacement (AVR): (1) experience with current clinical decision-making regarding prosthetic valve selection, (2) preferences for SDM and risk presentation and (3) prosthetic valve knowledge and numeracy. METHODS:In a prospective multicentre cohort study, AVR patients were surveyed preoperatively and 3 months post... Abstract

Cited 6 times since 2015 (1.1 per year) source: EuropePMC

Critical care medicine, Volume 43, Issue 2, 01 February 2015, Pages 373-381 Postoperative pro-adrenomedullin levels predict mortality in thoracic surgery patients: comparison with Acute Physiology and Chronic Health Evaluation IV Score*. Schoe A, Schippers EF, Struck J, Ebmeyer S, Klautz RJ, de Jonge E, van Dissel JT

OBJECTIVES: Risk assessment in ICU patients using commonly used prognostic models may be influenced using different data definitions and by errors in data collection. We investigated whether a set of biomarkers (procalcitonin, MR-pro-adrenomedullin, CT-pro-endothelin-1, CT-pro-arginine vasopressin, and MR-pro-atrial natriuretic peptide), alone or as a panel, could be useful in postoperative risk assessment for hospital mortality in comparison with the Acute Physiology and Chronic Health Evaluati... Abstract

Cited 10 times since 2015 (1.8 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 2, 01 February 2015, Pages 102-108 Left ventricular assist device for end-stage heart failure: results of the first LVAD destination program in the Netherlands. Haeck ML, Beeres SL, Höke U, Palmen M, Couperus LE, Delgado V, Logeman EA, Maas JJ, Klautz RJ, Schalij MJ, Verwey HF

PURPOSE: Mechanical circulatory support with a continuous-flow left ventricular assist device (LVAD) may be a valuable treatment in end-stage heart failure patients for an extended period of time. The purpose of this study was to evaluate the safety and efficacy of implantation of a continuous-flow LVAD in end-stage heart failure patients within the first destination program in the Netherlands. METHODS: A third-generation LVAD was implanted in 16 heart failure patients (age 61 ± 8; 81 % ma... Abstract

Cited 9 times since 2014 (1.5 per year) source: Scopus

Heart rhythm, Volume 12, Issue 3, 07 November 2014, Pages 533-539 Epicardial leads in adult cardiac resynchronization therapy recipients: a study on lead performance, durability, and safety. Buiten MS, van der Heijden AC, Klautz RJM, Schalij MJ, van Erven L

Transvenous left ventricular (LV) lead placement for cardiac resynchronization therapy-defibrillator (CRT-D) delivery is unsuccessful in 8% to 10% of cases. These patients might benefit from an epicardial lead. However, data on long-term epicardial lead performance are scarce. Furthermore, extracting an epicardial lead requires a rethoracotomy.The purpose of this study was to determine data on almost a decade of experience with epicardial leads and investigate the safety of partially leaving thi... Abstract

Cited 9 times since 2014 (1.5 per year) source: Scopus

Journal of cardiac surgery, Volume 30, Issue 1, 17 October 2014, Pages 13-19 Aortic valve repair versus replacement for aortic regurgitation: effects on left ventricular remodeling. Regeer MV, Versteegh MI, Klautz RJ, Stijnen T, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

BACKGROUND: Left ventricular (LV) reverse remodeling after aortic valve replacement (AVR) for aortic regurgitation (AR) is associated with superior prognosis. The outcomes of valve-sparing aortic root replacement techniques on LV performance have not been compared with LV reverse remodeling in AVR. The present evaluation compared the extent of long-term LV reverse remodeling in patients with aortic root pathology and/or AR who underwent aortic valve repair (AVr) with patients who underwent AVR.... Abstract

Cited 16 times since 2014 (2.6 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 9, 01 September 2014, Pages 363-369 Normal and abnormal development of the aortic wall and valve: correlation with clinical entities. Grewal N, DeRuiter MC, Jongbloed MR, Goumans MJ, Klautz RJ, Poelmann RE, Gittenberger-de Groot AC

Dilation of the wall of the thoracic aorta can be found in patients with a tricuspid (TAV) as well as a bicuspid aortic valve (BAV) with and without a syndromic component. BAV is the most common congenital cardiovascular malformation, with a population prevalence of 0.5-2 %. The clinical course is often characterised by aneurysm formation and in some cases dissection. The non-dilated aortic wall is less well differentiated in all BAV as compared with TAV, thereby conferring inherent development... Abstract

Cited 24 times since 2014 (3.9 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 5, 26 August 2014, Pages 831-839 Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. Grewal N, Gittenberger-de Groot AC, DeRuiter MC, Klautz RJ, Poelmann RE, Duim S, Lindeman JH, Koenraadt WM, Jongbloed MR, Mohamed SA, Sievers HH, Bogers AJ, Goumans MJ

OBJECTIVES: The clinical course of many patients with a bicuspid aortic valve (BAV) is complicated by ascending aortic dilatation. Currently, the indication for aortic surgery is solely based on the aortic diameter and subsequently only a small proportion of BAV patients undergoing valve surgery require concomitant ascending aortic replacement based on these recommendations. Unfortunately, a substantial number of BAV patients still develop aortic dilatation in the future and would potentially be... Abstract

Cited 3 times since 2014 (0.5 per year) source: Scopus

Perfusion, Volume 30, Issue 4, 01 August 2014, Pages 295-301 Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic. van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH

Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble... Abstract

Cited 12 times since 2014 (1.9 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 7-8, 01 August 2014, Pages 336-343 Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter? Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ

AIMS: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. METHODS AND RESULTS: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 %... Abstract