Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
196 results
Surgical technology international, Volume 41, 20 3 2022, Pages sti41/1575 Robotic Mitral Valve Surgery. Palmen M, Tomšič A, Braun J, Oudeman MAP, Shahin GMM, Klautz RJM
Growing interest in minimalizing surgical trauma during heart procedures stimulated the development of robotic mitral valve surgery in the late 1990s. Initially, the new technology was slowly adopted in clinical practice. However, following encouraging results by teams that adopted robotic heart surgery early on, a growing interest in implementation of robotic mitral valve surgery has emerged. Of importance are the technical developments and possibilities that accompany robotic surgery. Robotic... Abstract
Cited 2 times since 2022 (1.3 per year) source: EuropePMC
BMJ open, Volume 12, Issue 9, 19 3 2022, Pages e061337 Prevention of vasoplegia with CytoSorb in heart failure patients undergoing cardiac surgery (CytoSorb-HF trial): protocol for a randomised controlled trial. Papazisi O, Bruggemans EF, Berendsen RR, Hugo JDV, Lindeman JHN, Beeres SLMA, Arbous MS, van den Hout WB, Mertens BJA, Ince C, Klautz RJM, Palmen M
Introduction: Vasoplegia is a common complication after cardiac surgery and is associated with poor prognosis. It is characterised by refractory hypotension despite normal or even increased cardiac output. The pathophysiology is complex and includes the systemic inflammatory response caused by cardiopulmonary bypass (CPB) and surgical trauma. Patients with end-stage heart failure (HF) are at increased risk for developing vasoplegia. The CytoSorb adsorber is a relatively new haemoadsorption devic... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 115, Issue 6, 21 3 2022, Pages 1396-1402 The Aortic Root in Acute Type A Dissection: Repair or Replace? Arabkhani B, Verhoef J, Tomšič A, van Brakel TJ, Hjortnaes J, Klautz RJM
Background: The effect of an "aggressive" approach on the aortic root in acute type A aortic dissection (ATAAD) remains insufficiently explored. Methods: Retrospective analysis was conducted between 1992 and 2020 of a single-center, prospective cohort of consecutive patients aged ≥18 years diagnosed with ATAAD. Patients were divided into 2 groups: aortic root replacement (ARR; prosthetic or valve-sparing root replacement, n = 141) and conservative root approach (CRA; root sparing of pa... Abstract
Interactive cardiovascular and thoracic surgery, Volume 35, Issue 2, 1 1 2022, Pages ivac171 From macro-effective to microinvasive: what is the right balance? Tomšič A, Klautz RJM, Palmen M
Cited 12 times since 2022 (6.7 per year) source: EuropePMC
Annals of cardiothoracic surgery, Volume 11, Issue 4, 1 1 2022, Pages 380-388 Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve. Grewal N, Gittenberger-de Groot AC, Lindeman JH, Klautz A, Driessen A, Klautz RJM, Poelmann RE
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic dissection. Vascular smooth muscle cells in both the non- and dilated aortic wall are characterized by a maturation defect in all BAV patients, as compared to patients with a tricuspid aortic valve, which can contribute to inherent developmental susce... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 34, Issue 6, 1 1 2022, Pages 990-998 Long-term follow-up of thoracoscopic ablation in long-standing persistent atrial fibrillation. Harlaar N, Oudeman MA, Trines SA, de Ruiter GS, Mertens BJ, Khan M, Klautz RJM, Zeppenfeld K, Tjon A, Braun J, van Brakel TJ
Objectives: Catheter ablation of long-standing persistent atrial fibrillation (LSPAF) remains challenging, with suboptimal success rates obtained following multiple procedures. Thoracoscopic ablation has shown effective at creating transmural lesions around the pulmonary veins and box; however, long-term rhythm follow-up data are lacking. This study aims, for the first time, to assess the long-term outcomes of thoracoscopic pulmonary vein and box ablation in LSPAF. Methods: Rhythm follow-up cons... Abstract
The New England journal of medicine, Volume 386, Issue 19, 1 1 2022, Pages 1862 Tricuspid Repair in Patients with Degenerative Mitral Regurgitation. Tomšič A, Palmen M, Klautz RJM
American heart journal, Volume 249, 15 3 2022, Pages 66-75 Computed tomography follow-up after elective proximal aortic surgery: Less is more? de Oliveira Marreiros DJ, Tomšič A, van Brakel TJ, Hamming JF, Scholte AJHA, Hjortnaes J, Klautz RJM
Study objective: The added value of computed tomography (CT) follow-up after elective proximal aortic surgery is unclear. We evaluated the benefit of CT follow-up by assessing the incidence of aorta-related complications and reinterventions detected during routine CT follow-up. Methods: Data on 314 patients undergoing first time elective proximal aortic surgery between 2000 and 2015 were collected. The primary study end points were aorta-related complications and reinterventions, detected during... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
The American journal of cardiology, Volume 173, 1 1 2022, Pages 48-55 Meta-Analysis of Bilateral Versus Single Internal Thoracic Artery Grafting in Patients ≥70 Years of Age. Mulder BS, Candura D, Schoones JW, Etnel JRG, Schouten GN, de Weger A, Tomšič A, Klautz RJM
The optimal choice of graft material in patients ≥70 years of age undergoing coronary artery bypass grafting remains unknown. A systematic review of literature was conducted by searching PubMed, Embase, Web of Science, and Cochrane Library databases for original publications that compared bilateral internal thoracic artery (BITA) grafting with single internal thoracic artery grafting in patients ≥70 years of age. Data were extracted by 2 independent investigators and meta-analyzed with the use o... Abstract
Cited 11 times since 2022 (4.8 per year) source: EuropePMC
Nature biomedical engineering, Volume 6, Issue 4, 6 1 2022, Pages 389-402 Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat... Abstract
Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2021, 25 4 2021 Patch repair in infective native mitral valve endocarditis. Velders BJJ, Tomšič A, Klautz RJM, Palmen M
Infective native mitral valve endocarditis occurs rarely. Mitral valve repair, although surgically challenging, is favored over replacement in the latest European and American guidelines. In this video tutorial, patch repair of the posterior mitral valve leaflet is performed in a 61-year-old patient with endocarditis caused by Streptococcus agalactiae. Abstract
Cited 8 times since 2021 (3 per year) source: EuropePMC
Open heart, Volume 8, Issue 2, 1 1 2021, Pages e001772 Comparative evaluation of coronary disease burden: bicuspid valve disease is not atheroprotective. Dolmaci OB, Driessen AHG, Klautz RJM, Poelmann R, Lindeman JHN, Grewal N
Objective: Bicuspid aortic valve (BAV) has been associated with less atherosclerosis as compared with tricuspid aortic valve (TAV) patients. It, however, remains unclear whether this reflects the older age of TAV patients and/or accumulation of atherosclerotic risk factors or that the BAV phenotype is atheroprotective. Therefore, we compared the atherosclerotic disease burden of BAV and TAV patients, with that of the general (age-matched) population. Methods: The prevalence of coronary artery di... Abstract
Cited 10 times since 2021 (3.5 per year) source: EuropePMC
Journal of the American Heart Association, Volume 10, Issue 12, 2 1 2021, Pages e020080 Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves. Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A... Abstract
Cited 6 times since 2021 (2 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 32, Issue 4, 1 1 2021, Pages 506-514 Evolution from mitral annular dysfunction to severe mitral regurgitation in Barlow's disease. Hiemstra YL, Tomsic A, Gripari P, van Wijngaarden AL, van der Pas SL, Palmen M, Klautz RJM, Pepi M, Bax JJ, Delgado V, Marsan NA
Objectives: Barlow's disease (BD) is characterized by thick, redundant mitral valve (MV) leaflets, which can lead to prolapse and significant mitral regurgitation (MR). MV annular abnormalities are also commonly observed and increasingly recognized as possible primary pathology, with leaflet thickening being secondary to increased stress on the MV apparatus. To provide more insights into this hypothesis, the evolution of MV abnormalities over time in patients with BD was assessed. Methods:... Abstract
Cited 3 times since 2021 (1 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 164, Issue 5, 23 4 2021, Pages 1488-1497.e3 Mitral valve repair for isolated posterior mitral valve leaflet prolapse: The effect of respect and resect techniques on left ventricular function. van Wijngaarden AL, Tomšič A, Mertens BJA, Fortuni F, Delgado V, Bax JJ, Klautz RJM, Marsan NA, Palmen M
Objective: Posterior mitral valve leaflet prolapse repair can be performed by leaflet resection or chordal replacement techniques. The impact of these techniques on left ventricular function remains a topic of debate, considering the presumed better preservation of mitral-ventricular continuity when leaflet resection is avoided. We explored the effect of different posterior mitral valve leaflet repair techniques on postoperative left ventricular function. Methods: In total, 125 patients were inc... Abstract
Cited 12 times since 2021 (3.7 per year) source: EuropePMC
Journal of cardiovascular development and disease, Volume 8, Issue 2, 27 4 2021, Pages 12 A Systematic Histopathologic Evaluation of Type-A Aortic Dissections Implies a Uniform Multiple-Hit Causation. Grewal N, Velders BJJ, Gittenberger-de Groot AC, Poelmann R, Klautz RJM, Van Brakel TJ, Lindeman JHN
(1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall specimens (n = 58, mean age 63 years) with TAAD were collected. Autopsy tissues (n = 17, mean age 63 years) served as controls. All sections were studied histopathologically. (3) Results: Pathomorphology in TAAD showed predominantly moderate elastic f... Abstract
EClinicalMedicine, Volume 31, 23 4 2020, Pages 100661 Continuous postoperative pericardial flushing reduces postoperative bleeding after coronary artery bypass grafting: A randomized trial. Diephuis EC, de Borgie CA, Zwinderman A, Winkelman JA, van Boven WP, Henriques JPS, Eberl S, Juffermans NP, Schultz MJ, Klautz RJM, Koolbergen DR
Background: Prolonged or excessive bleeding after cardiac surgery can lead to a broad spectrum of secondary complications. One of the underlying causes is incomplete wound drainage, with subsequent accumulation of blood and clots in the pericardium. We developed the continuous postoperative pericardial flushing (CPPF) therapy to improve wound drainage and reduce postoperative blood loss and bleeding-related complications after cardiac surgery. This study compared CPPF to standard care in patient... Abstract
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
Journal of cardiac surgery, Volume 35, Issue 12, 21 3 2020, Pages 3477-3485 Prosthesis-patient mismatch after mitral valve replacement: A pooled meta-analysis of Kaplan-Meier-derived individual patient data. Tomšič A, Arabkhani B, Schoones JW, Etnel JRG, Marsan NA, Klautz RJM, Palmen M
Objective: The hemodynamic effect and early and late survival impact of prosthesis-patient mismatch (PPM) after mitral valve replacement remains insufficiently explored. Methods: Pubmed, Embase, Web of Science, and Cochrane Library databases were searched for English language original publications. The search yielded 791 potentially relevant studies. The final review and analysis included 19 studies compromising 11,675 patients. Results: Prosthetic effective orifice area was calculated with the... Abstract
Cited 7 times since 2020 (1.9 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 58, Issue 3, 1 1 2020, Pages 544-550 A structured approach to native mitral valve infective endocarditis: Is repair better than replacement? Defauw RJ, Tomšič A, van Brakel TJ, Marsan NA, Klautz RJM, Palmen M
Objectives: Mitral valve repair in native active infective endocarditis is technically challenging. The survival benefit over valve replacement is poorly established and possibly absent because of the high risk of repair failure and reoperation. In this study, we explore the results of our structured approach in these patients. Methods: Between January 2000 and January 2017, 149 patients underwent surgery for native mitral infective endocarditis. Among them, 97 (66%) patients underwent valve rep... Abstract
Cited 8 times since 2020 (2 per year) source: EuropePMC
JMIR research protocols, Volume 9, Issue 4, 21 3 2020, Pages e16326 Use of Smart Technology for the Early Diagnosis of Complications After Cardiac Surgery: The Box 2.0 Study Protocol. Biersteker TE, Boogers MJ, de Lind van Wijngaarden RA, Groenwold RH, Trines SA, van Alem AP, Kirchhof CJ, van Hof N, Klautz RJ, Schalij MJ, Treskes RW
Background: Atrial fibrillation (AF), sternal wound infection, and cardiac decompensation are complications that can occur after cardiac surgery. Early detection of these complications is clinically relevant, as early treatment is associated with better clinical outcomes. Remote monitoring with the use of a smartphone (mobile health [mHealth]) might improve the early detection of complications after cardiac surgery. Objective: The primary aim of this study is to compare the detection rate of AF... Abstract