Research

Publications

Below you can find a list of our published research.

21 results

Heart (British Cardiac Society), 15 January 2021 Sacubitril/valsartan in the treatment of systemic right ventricular failure. Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD

ObjectivePharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients.MethodsData on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circulati... Abstract

Interactive cardiovascular and thoracic surgery, Volume 32, Issue 1, 01 January 2021, Pages 122-129 The significance of symptoms before and after surgery for anomalous aortic origin of coronary arteries in adolescents and adults. Meijer FMM, Egorova AD, Jongbloed MRM, Koppel C, Habib G, Hazekamp MG, Vliegen HW, Kies P

ObjectivesThe aim of this study is to describe the significance of symptoms preoperatively and at medium-term follow-up in adolescent and adult patients who underwent surgery of anomalous aortic origin of a coronary artery (AAOCA).MethodsConsecutive patients who underwent surgery for AAOCA in our tertiary referral centre between 2001 and 2018 were included. Clinical characteristics and symptoms were evaluated and medium-term outcomes were recorded. Symptoms were classified according to the '2019... Abstract

Pacing and clinical electrophysiology : PACE, Volume 44, Issue 1, 12 November 2020, Pages 120-128 Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach. Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L

The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile rang... Abstract

European heart journal. Case reports, Volume 4, Issue 5, 15 October 2020, Pages 1-3 Pulmonary hypertension causing left main coronary artery compression. Verheijen DBH, Meijer FMM, Kiès P, Egorova AD

Abstract

European heart journal. Cardiovascular pharmacotherapy, 25 September 2020 Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations. Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ

AimsHeart failure is the main threat to long-term health in adults with transposition of the great arteries(TGA) corrected by an atrial switch operation(AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of Renin-Angiotens... Abstract

European heart journal, 18 September 2020 A case of tortuous anatomy: cervical aortic arch. van Driest FY, Stöger JL, Scholte AJHA, Jukema JW, Egorova AD

Abstract

Clinical case reports, Volume 8, Issue 11, 06 August 2020, Pages 2320-2321 The constrictive consequences of pericardial calcifications. Egorova AD, Schalij MJ, Kiès P

A 53-year-old man presented with symptomatic severe pulmonary valve regurgitation. He underwent a diagnostic catheterization. A heavily calcified pericardium and the pressure tracings illustrate typical features of constrictive pericarditis physiology, including the "square root sign." This condition is important to recognize given the progressive nature and poor prognosis if untreated. Abstract

Journal of electrocardiology, Volume 61, 05 June 2020, Pages 141-146 Lack of diagnostic utility of the ECG-derived ventricular gradient in patients with suspected acute pulmonary embolism. Meijer FMM, Hendriks SV, Huisman MV, van der Hulle T, Swenne CA, Kies P, Jongbloed MRM, Egorova AD, Vliegen HW, Klok FA

INTRODUCTION:The YEARS algorithm was successfully developed to reduce the number of computed tomography pulmonary angiography (CTPA) investigations in the diagnostic management of patients with suspected pulmonary embolism (PE), although half of patients still needed to be referred for CTPA. We hypothesized that ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO), an easy to use tool for detecting PE-induced pulmonary hypertension (PH), may further improv... Abstract

European heart journal. Case reports, Volume 4, Issue 3, 17 April 2020, Pages 1-5 Anomalous left coronary artery from the pulmonary artery: a rare cause of an out-of-hospital cardiac arrest in an adult-a case report. Regeer MV, Bondarenko O, Zeppenfeld K, Egorova AD

Background:Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital disorder resulting in ischaemia and myocardial infarction which can act as a potential substrate for life-threatening arrhythmias and sudden cardiac death. Case summary:A 19-year-old man was admitted to the hospital after successful resuscitation from an out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation occurring during jogging. In the diagnostic work-up of the OHCA, computed tom... Abstract

European heart journal. Case reports, Volume 4, Issue 2, 21 February 2020, Pages 1-6 Successful percutaneous occlusion of a large left circumflex coronary artery fistula draining into the coronary sinus using a ventricular septal defect occluder: a case report. Egorova AD, Ewert P, Hadamitzky M, Eicken A

Background:Coronary artery fistula (CAF) is a congenital anomaly of the coronaries that can lead to significant intracardiac shunting and myocardial ischaemia. Case summary:We describe the case of a 15-year-old male with an incidentally documented precordial cardiac murmur. An evidently dilated coronary sinus (CS) on transthoracic echocardiography prompted further investigation. A computed tomography (CT) revealed the presence of a large CAF from the left circumflex coronary artery to the CS. No... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 2, 01 February 2020, Pages 104-107 A 55-year-old man with mild shortness of breath. Egorova AD, Smit JM, Kiès P

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 2, 01 February 2020, Pages 110-111 A 55-year-old man with mild shortness of breath. Egorova AD, Smit JM, Kiès P

Abstract

Cited 3 times since 2019 (2.6 per year) source: Scopus

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 01 December 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF

Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally co... Abstract

Cited 50 times since 2012 (5.6 per year) source: Scopus

Science signaling, Volume 5, Issue 212, 21 February 2012, Pages pt2 TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia. Ten Dijke P, Egorova AD, Goumans MJ, Poelmann RE, Hierck BP

Endothelial-to-mesenchymal transition (EndoMT) is an instrumental step in the development of valves in the embryonic heart. This process is driven by activation of transforming growth factor-β (TGF-β) signaling and is characterized by the loss of endothelial and gain of mesenchymal phenotype, and by delamination of cells from the surface into the underlying endocardial cushion matrix. The endothelial cells (ECs) overlying the cushions are typically exposed to high blood flow and concomitant sh... Abstract

Cited 43 times since 2011 (4.7 per year) source: Scopus

Differentiation; research in biological diversity, Volume 83, Issue 2, 09 December 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP

Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract

Cited 30 times since 2011 (3.3 per year) source: Scopus

In vitro cellular & developmental biology. Animal, Volume 48, Issue 1, 20 November 2011, Pages 21-29 Endothelial colony-forming cells show a mature transcriptional response to shear stress. Egorova AD, DeRuiter MC, de Boer HC, van de Pas S, Gittenberger-de Groot AC, van Zonneveld AJ, Poelmann RE, Hierck BP

Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic applications. The extent to which these cells respond to shear stress as adult vascular EC remains to be elucidated. Here, we study the transcr... Abstract

Cited 45 times since 2011 (4.6 per year) source: Scopus

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 7, 20 May 2011, Pages 1670-1680 Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells. Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJ, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP

Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC in areas of high shear stress, i.e., in the cardiac outflow tract and atrioventricular canal, are characterized by high expression of Krüppel-like factor 2 (Klf2) and by transforming growth factor-beta (Tgfβ)-driven endothelial-to-mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results in congenital heart... Abstract

Cited 118 times since 2011 (11.9 per year) source: Scopus

Circulation research, Volume 108, Issue 9, 10 March 2011, Pages 1093-1101 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP

RationalePrimary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitric oxide production and initiation of gene expression. Cilia are present on ECs in areas of low or disturbed flow and absent in areas of high flow. In the embryonic heart, high-flow regime applies to the endocardial cushion area, and the absence of cilia here coincides with the pro... Abstract

Cited 17 times since 2011 (1.7 per year) source: EuropePMC

International review of cell and molecular biology, Volume 290, 01 January 2011, Pages 87-119 Role for primary cilia as flow detectors in the cardiovascular system. Van der Heiden K, Egorova AD, Poelmann RE, Wentzel JJ, Hierck BP

The cardiovascular system is exposed to biochemical and biomechanical signals. Various sensors for these signals have been described and they contribute to cardiovascular development, maintenance of vessel integrity during adult life, and to pathogenesis. In the past 10years, primary cilia, membrane-covered, rod-like cellular protrusions, were discovered on multiple cell types of the cardiovascular system. Primary cilia are sensory organelles involved in several key (developmental) signaling pat... Abstract

Meditsinskaia parazitologiia i parazitarnye bolezni, Volume 37, Issue 3, 01 May 1968, Pages 302-305 [Natural infection of chigger mites with Rickettsia tsutsugamushi in the Primorsky territory] Kudriashova NI, Miroliubova LV, Tarasevich IV, Plotnikova LF, Egorova AD

Abstract