Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
111 results
Cited 4 times since 2009 (0.3 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 5, Issue 5, 1 1 2009, Pages 565-572 Impact of sirolimus-eluting stent implantation compared to bare-metal stent implantation for acute myocardial infarction on coronary plaque composition at nine months follow-up: a Virtual Histology intravascular ultrasound analysis. Results from the Leiden MISSION! intervention study. Atary JZ, Bergheanu SC, van der Hoeven BL, Atsma DE, Bootsma M, van der Kley F, Zeppenfeld K, Jukema JW, Schalij MJ
Aims: To evaluate effects of sirolimus-eluting stents (SES) compared to bare-metal stents (BMS) at stent edges in patients with acute myocardial infarction (AMI). Methods and results: Clinical, angiographic, intravascular ultrasound (lVUS) and virtual histology (VH)-IVUS results were obtained and analysed in 20 SES and 20 BMS AMI patients at the index procedure and at nine months follow-up. Quantitative angiography and IVUS showed a trend toward decreases in mean lumen diameter, vessel volume, m... Abstract
Cited 26 times since 2009 (1.8 per year) source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 74, Issue 2, 1 1 2009, Pages 335-343 In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimization program. Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ
Objectives: Our aim was to evaluate the effects of early abciximab administration in the ambulance on immediate, short, and long term outcomes. Background: Early abciximab administration before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is recommended in practice guidelines. However, optimal timing of administration remains indistinct. Methods: Within a fixed protocol for PPCI, December 2006 was the cut-off point for this prospective... Abstract
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 20, Issue 10, 26 4 2009, Pages 1119-1127 Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K
Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and ventricular tachycardia (VT) are at risk of VT recurrence and sudden death. Data on patients with VT due to right ventricular (RV) scar not fulfilling TF criteria are lacking. The purpose of this study was to assess the long-term arrhythmia recurrence rate and outcome in patients with scar-related right VT with and without a diagnosis of ARVC/D. Methods... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
European heart journal, Volume 30, Issue 13, 2 1 2009, Pages 1621-1626 Recurrence of ventricular arrhythmias in ischaemic secondary prevention implantable cardioverter defibrillator recipients: long-term follow-up of the Leiden out-of-hospital cardiac arrest study (LOHCAT). Borleffs CJ, van Erven L, Schotman M, Boersma E, Kiès P, van der Burg AE, Zeppenfeld K, Bootsma M, van der Wall EE, Bax JJ, Schalij MJ
Aims: To assess the long-term rate of mortality and the recurrence of potentially life-threatening ventricular arrhythmias in secondary prevention implantable cardioverter defibrillator (ICD) patients and to construct a model for baseline risk stratification. Methods and results: Since 1996, all patients with ischaemic heart disease, receiving ICD therapy for secondary prevention of sudden death, were included in the current study. Patients were evaluated at implantation and during long-term fol... Abstract
Cited 127 times since 2008 (8.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 9, 26 4 2008, Pages 715-720 Risk factors and time delay associated with cardiac device infections: Leiden device registry. Lekkerkerker JC, van Nieuwkoop C, Trines SA, van der Bom JG, Bernards A, van de Velde ET, Bootsma M, Zeppenfeld K, Jukema JW, Borleffs JW, Schalij MJ, van Erven L
Aims: A nested case-control study of 75 patients with cardiac device infections (CDI) and 75 matched controls was conducted to evaluate time course, risk factors, culture results and frequency of CDI. Methods and results: CDI occurred in 75/3410 (2.2%) device implantation and revision procedures, performed between 2000 and 2007. The time delay between device procedure and infection ranged from 0 to 64 months (mean 14 (SD 16)), 21 patients (28%) had an early infection (12 months). Of interest, 18... Abstract
Cited 47 times since 2008 (2.9 per year) source: EuropePMC
JACC. Cardiovascular interventions, Volume 1, Issue 2, 1 1 2008, Pages 192-201 Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study. van der Hoeven BL, Liem SS, Dijkstra J, Bergheanu SC, Putter H, Antoni ML, Atsma DE, Bootsma M, Zeppenfeld K, Jukema JW, Schalij MJ
Objectives: Acute and late stent malapposition (SM) after bare-metal stents (BMS) and sirolimus-eluting stents (SES) in ST-segment elevation myocardial infarction patients were studied. Background: Stent thrombosis may be caused by SM after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients. Methods: Post-procedure and follow-up intravascular ultrasound data were available in 184 out of 310 patients (60%; 104 SES, 80 BMS) included in the MISSION! In... Abstract
Cited 89 times since 2008 (5.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 51, Issue 6, 1 1 2008, Pages 618-626 Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ
Objectives: Our purpose was to evaluate the efficacy and safety of drug-eluting stents in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). Background: There is inconsistent and limited evidence about the efficacy and safety of drug-eluting stents in STEMI patients. Methods: A single-blind, single-center, randomized study was performed to compare bare-metal stents (BMS) with sirolimus-eluting stents (SES) in 310 STEMI patients. The... Abstract
Cited 16 times since 2006 (0.9 per year) source: EuropePMC
Heart rhythm, Volume 4, Issue 1, 9 2 2006, Pages 88-91 Incessant ventricular tachycardia in fulminant lymphocytic myocarditis: Evidence for origin in the Purkinje system and successful treatment with ablation. Zeppenfeld K, Blom NA, Bootsma M, Schalij MJ
Cited 20 times since 2006 (1.1 per year) source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 43, Issue 5, 31 5 2006, Pages 616-623 Potential confounding in evaluating infection-control interventions in hospital settings: changing antibiotic prescription. Nijssen S, Bootsma M, Bonten M
The colonization dynamics of antibiotic-resistant pathogens in hospital settings are complex, with multiple and continuously interacting variables (e.g., introduction of resistance, infection-control practices, antibiotic use). Quantification of these variables is indispensable in the evaluation of intervention studies, because these variables represent potential confounders. In this article, the complexity of colonization dynamics is described. Through a systematic review, we identified studies... Abstract
Cited 16 times since 2006 (0.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 48, Issue 3, 12 2 2006, Pages 464-470 Benefit of combined resynchronization and defibrillator therapy in heart failure patients with and without ventricular arrhythmias. Ypenburg C, van Erven L, Bleeker GB, Bax JJ, Bootsma M, Wijffels MC, van der Wall EE, Schalij MJ
Objectives: We attempted to assess the efficacy of combined cardiac resynchronization therapy-implantable cardioverter-defibrillator (CRT-ICD) in heart failure patients with and without ventricular arrhythmias. Background: Because CRT and ICDs both lower all-cause mortality in patients with advanced heart failure, combination of both therapies in a single device is challenging. Methods: A total of 191 consecutive patients with advanced heart failure, left ventricular ejection fraction 120 ms rec... Abstract
Cited 20 times since 2006 (1.1 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 17, Issue 6, 1 1 2006, Pages 586-593 Serial reevaluation for ARVD/C is indicated in patients presenting with left bundle branch block ventricular tachycardia and minor ECG abnormalities. Kiès P, Bootsma M, Bax JJ, Zeppenfeld K, van Erven L, Wijffels MC, van der Wall EE, Schalij MJ
Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is based on a set of criteria proposed by the International Task Force (TF) for Cardiomyopathies in 1994. To fulfill these criteria, presence of both electrocardiographic and anatomical abnormalities must be assessed with ECG and imaging techniques, respectively. This may be difficult in patients with early/mild forms of the disease as detectable structural abnormalities may still be absent. We evaluate... Abstract
Cited 61 times since 2006 (3.3 per year) source: EuropePMC
Heart rhythm, Volume 3, Issue 2, 1 1 2006, Pages 225-234 Arrhythmogenic right ventricular dysplasia/cardiomyopathy: screening, diagnosis, and treatment. Kiès P, Bootsma M, Bax J, Schalij MJ, van der Wall EE
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a heart muscle disorder characterized pathologically by fatty or fibrofatty replacement and electrical instability of the right ventricular myocardium. Clinical manifestations include structural and functional malformations (fatty infiltration, dilatation, aneurysms) of the right ventricle, ECG abnormalities, and presentation with ventricular tachycardias with left bundle branch block pattern or sudden death. The disease often... Abstract
Cited 67 times since 2005 (3.6 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 46, Issue 12, 1 1 2005, Pages 2264-2269 Left ventricular dyssynchrony predicts right ventricular remodeling after cardiac resynchronization therapy. Bleeker GB, Schalij MJ, Nihoyannopoulos P, Steendijk P, Molhoek SG, van Erven L, Bootsma M, Holman ER, van der Wall EE, Bax JJ
Objectives: The purpose of this research was to evaluate right ventricular (RV) remodeling after six months of cardiac resynchronization therapy (CRT). Background: Cardiac resynchronization therapy is beneficial in patients with end-stage heart failure. The effect of CRT on RV size is currently unknown. Accordingly, the effects of CRT on RV size, severity of tricuspid regurgitation, and pulmonary artery pressure were evaluated. Methods: Fifty-six consecutive patients with end-stage heart failure... Abstract
Cited 14 times since 2005 (0.8 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1049-1056 Determinants of recurrent ventricular arrhythmia or death in 300 consecutive patients with ischemic heart disease who experienced aborted sudden death: data from the Leiden out-of-hospital cardiac arrest study. Kiès P, Boersma E, Bax JJ, van der Burg AE, Bootsma M, van Erven L, van der Wall EE, Schalij MJ
Objective: Evaluation of the relation between clinical characteristics and incidence of recurrent ventricular arrhythmias (VAs) or death during long-term follow-up in a cohort of 300 consecutive ischemic heart disease (IHD) patients who had survived an episode of sudden cardiac arrest (SCA). Background: Survivors of life-threatening VA are at high risk for recurrent events. Methods: A total of 300 consecutive survivors of SCA with IHD were included in a standardized screening and evaluation prot... Abstract
Cited 37 times since 2005 (2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 92, Issue 4, 13 2 2005, Pages 490-494 Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm. Kiès P, Leclercq C, Bleeker GB, Crocq C, Molhoek SG, Poulain C, van Erven L, Bootsma M, Zeppenfeld K, van der Wall EE, Daubert JC, Schalij MJ, Bax JJ
Objective: To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF). Patients: 74 consecutive patients (age 68 (8) years; 67 men) with advanced heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT device. Main outcome measures: Patients were evaluated clinically (New York Heart Association (NYHA)... Abstract
Cited 27 times since 2005 (1.4 per year) source: EuropePMC
Heart rhythm, Volume 2, Issue 9, 1 1 2005, Pages 940-950 Identification of successful catheter ablation sites in patients with ventricular tachycardia based on electrogram characteristics during sinus rhythm. Zeppenfeld K, Kiès P, Wijffels MC, Bootsma M, van Erven L, Schalij MJ
Background: Zones of slow conduction facilitate reentry, the major mechanism of ventricular tachycardia (VT) after myocardial infarction (MI). Identification of these zones during sinus rhythm (SR) is desirable for radiofrequency (RF) catheter ablation of VT. Local conduction velocity may correlate with electrogram duration. Objectives: The purpose of this study was to revise the definition of normal electrogram characteristics and to reevaluate the significance of low-amplitude, long-duration e... Abstract
Cited 25 times since 2005 (1.3 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 16, Issue 7, 1 1 2005, Pages 701-707 Long-term follow-up of cardiac resynchronization therapy in patients with end-stage heart failure. Molhoek SG, Bax JJ, Bleeker GB, Holman ER, Van Erven L, Bootsma M, Boersma E, Steendijk P, Van Der Wall EE, Schalij MJ
Unlabelled: Long-term follow-up of cardiac resynchronization therapy. Introduction: Cardiac resynchronization therapy (CRT) has been introduced to treat patients with end-stage heart failure, and results of this technique are promising. The aim of our study was to assess the sustained benefit of CRT in a large patient cohort with end-stage heart failure at long-term follow-up. In addition, the prognosis of responders and nonresponders was evaluated. Methods and results: 125 patients with end-sta... Abstract
Cited 4 times since 2005 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 24, 1 1 2005, Pages 1339-1346 [Radiofrequency catheter ablation for treating children with cardiac arrhythmias: favourable results after a mean of 4 years]. Kolditz DP, Blom NA, Bökenkamp R, Bootsma M, Zeppenfeld K, Schalij MJ
Objective: Analysis of long-term results with radiofrequency catheter ablation (RF ablation) in children. Design: Retrospective. Method: Data were analysed from all 118 paediatric patients < or =18 years old who underwent RF ablation at the Leiden University Medical Centre (LUMC), the Netherlands, during the period 1 December 1992-31 May 2004. Results: The group consisted of 6o boys and 58 girls with a mean age of 12.7 years (SD: 4.6). They underwent 140 RF ablation procedures for 122 disorde... Abstract
Cited 16 times since 2005 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 95, Issue 9, 1 1 2005, Pages 1111-1114 Effect of cardiac resynchronization therapy on inducibility of ventricular tachyarrhythmias in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, van Erven L, Steendijk P, van der Wall EE, Schalij MJ
We evaluated whether long-term cardiac resynchronization therapy affects the inducibility of ventricular tachyarrhythmias in relation to reverse remodeling in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Clinical, electrophysiologic, and echocardiographic data of 18 patients were obtained before and after 6 months of cardiac resynchronization. Abstract
Cited 25 times since 2004 (1.3 per year) source: EuropePMC
The American journal of cardiology, Volume 94, Issue 1, 1 1 2004, Pages 130-132 Effect of left ventricular remodeling after cardiac resynchronization therapy on frequency of ventricular arrhythmias. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, St John Sutton M, van Erven L, van der Wall EE, Schalij MJ
We evaluated whether cardiac resynchronization therapy affects the prevalence of ventricular tachycardia in relation to reverse remodeling in patients with end-stage heart failure. Clinical, echocardiographic, and implantable cardioverter-defibrillator (ICD) data of 17 patients with ICDs were obtained before and after they had received an upgrade to an ICD-cardiac resynchronization therapy device. Abstract