Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
111 results
Cited 4 times since 2022 (2.1 per year) source: EuropePMC
International journal of cardiology, Volume 363, 15 3 2022, Pages 87-93 Left atrioventricular coupling index in hypertrophic cardiomyopathy and risk of new-onset atrial fibrillation. Meucci MC, Fortuni F, Galloo X, Bootsma M, Crea F, Bax JJ, Marsan NA, Delgado V
Backgrounds: This study aimed to investigate the association between left atrioventricular coupling index (LACI) and the occurrence of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). Methods: A total of 373 patients with HCM and no history of AF were evaluated by transthoracic echocardiography. LACI was defined by the ratio of left atrial (LA) end-diastolic volume divided by left ventricular (LV) end-diastolic volume. The cut-off value for LACI (≥40%) to identify LA-... Abstract
Cited 8 times since 2022 (4.2 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 40, Issue 31, 26 4 2022, Pages 3633-3641 Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma. Bootsma M, McKay RR, Emamekhoo H, Bade RM, Schehr JL, Mannino MC, Singh A, Wolfe SK, Schultz ZD, Sperger J, Xie W, Signoretti S, Kyriakopoulos CE, Kosoff D, Abel EJ, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Bassetti M, Floberg J, Yu M, Sethakorn N, Sharifi M, Harari PM, Choueiri TK, Lang JM, Zhao SG
Purpose: Liquid biopsies in metastatic renal cell carcinoma (mRCC) provide a unique approach to understand the molecular basis of treatment response and resistance. This is particularly important in the context of immunotherapies, which target key immune-tumor interactions. Unlike metastatic tissue biopsies, serial real-time profiling of mRCC is feasible with our noninvasive circulating tumor cell (CTC) approach. Methods: We collected 457 longitudinal liquid biopsies from 104 patients with mRCC... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 23, Issue 9, 1 1 2021, Pages 1487-1492 Five cases of complete atrioventricular block induced by bending forward: unusual but not unique. Saal DP, Thijs RD, Bootsma M, Brignole M, van Dijk JG
Aims: We describe five patients with syncope caused by a complete atrioventricular block (AVB) while they were bending forward, not rising after bending, and aim to describe the occurrence and the association between bending forward and AVB. Methods and results: In two patients, bending forward was the exclusive trigger for syncope, while in the remaining three, other postural changes (sitting down, standing up, and exertion) could also provoke syncope. Complete AVB as the cause of syncope was d... Abstract
Cited 5 times since 2021 (1.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 22, Issue 5, 1 1 2021, Pages 589-596 Assessment of left atrial electro-mechanical delay to predict atrial fibrillation in hypertrophic cardiomyopathy. Tjahjadi C, Hiemstra YL, van der Bijl P, Pio SM, Bootsma M, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and is associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects the left atrial (LA) structural and electrical remodelling. The aim of this study was to evaluate the association between PA-TDI and new-onset AF in patients with HCM. Methods and results: From a large cohort of patients with HCM, 208 patients (64% m... Abstract
Cited 2 times since 2020 (0.6 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 44, Issue 1, 12 2 2020, Pages 120-128 Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach. Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L
The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range... Abstract
Journal of cardiology, Volume 76, Issue 5, 19 3 2020, Pages 514-520 QT interval variability and heart rate turbulence are associated with clinical characteristics in congenital heart disease patients with a systemic right ventricle. Zandstra T, Kiès P, Man SC, Maan A, Bootsma M, Vliegen H, Egorova A, Holman E, Schalij M, Jongbloed M
Background: QT interval variability (QTV) and heart rate turbulence (HRT) are measures of cardiac autonomic function, which, when abnormal, are correlated with ventricular arrhythmias and worse clinical outcome. This study aims to evaluate QTV and HRT in patients with a systemic right ventricle (RV) and to assess correlations with clinical characteristics. Methods: In a retrospective cohort study, QTV and HRT were derived from 24-h Holter registrations of patients with a systemic RV and healthy... Abstract
Cited 4 times since 2020 (1 per year) source: EuropePMC
Autonomic neuroscience : basic & clinical, Volume 227, 26 4 2020, Pages 102696 Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle. Zandstra T, Kiès P, Maan A, Man SC, Bootsma M, Vliegen H, Egorova A, Mertens B, Holman E, Schalij M, Jongbloed M
Background: Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. Methods: 24-Hour Holter recordings of patients with a systemic right ventricle and healthy controls were a... Abstract
Cited 15 times since 2020 (3.8 per year) source: EuropePMC
Bioinformatics (Oxford, England), Volume 36, Issue 12, 1 1 2020, Pages 3874-3876 gplas: a comprehensive tool for plasmid analysis using short-read graphs. Arredondo-Alonso S, Bootsma M, Hein Y, Rogers MRC, Corander J, Willems RJL, Schürch AC
Summary: Plasmids can horizontally transmit genetic traits, enabling rapid bacterial adaptation to new environments and hosts. Short-read whole-genome sequencing data are often applied to large-scale bacterial comparative genomics projects but the reconstruction of plasmids from these data is facing severe limitations, such as the inability to distinguish plasmids from each other in a bacterial genome. We developed gplas, a new approach to reliably separate plasmid contigs into discrete componen... Abstract
Cited 6 times since 2020 (1.5 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 13, Issue 8, 15 3 2020, Pages 1852-1854 Regional Left Ventricular Myocardial Work Indices and Response to Cardiac Resynchronization Therapy. Kostyukevich MV, van der Bijl P, Vo NM, Lustosa RP, Pio SM, Bootsma M, Ajmone Marsan N, Delgado V, Bax JJ
Cited 8 times since 2019 (1.8 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 21, Issue 10, 1 1 2019, Pages 1519-1526 Incidence and predictors of implantable cardioverter-defibrillator therapy and its complications in idiopathic ventricular fibrillation patients. Blom LJ, Visser M, Christiaans I, Scholten MF, Bootsma M, van den Berg MP, Yap SC, van der Heijden JF, Doevendans PA, Loh P, Postema PG, Barge-Schaapsveld DQ, Hofman N, Volders PGA, Wilde AA, Hassink RJ
Aims: Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest. Implantable cardioverter-defibrillator (ICD) implantation is currently the only treatment option. Limited data are available on the prevalence and complications of ICD therapy in these patients. We sought to investigate ICD therapy and its complications in patients with IVF. Methods and results: Patients were selected from a national registry of IVF patients. Patients in whom no underlying diagnosis was fou... Abstract
Cited 6 times since 2019 (1.3 per year) source: EuropePMC
Molecular ecology resources, Volume 20, Issue 1, 1 1 2019, Pages 66-78 Attack of the PCR clones: Rates of clonality have little effect on RAD-seq genotype calls. Euclide PT, McKinney GJ, Bootsma M, Tarsa C, Meek MH, Larson WA
Interpretation of high-throughput sequence data requires an understanding of how decisions made during bioinformatic data processing can influence results. One source of bias that is often cited is PCR clones (or PCR duplicates). PCR clones are common in restriction site-associated sequencing (RAD-seq) data sets, which are increasingly being used for molecular ecology. To determine the influence PCR clones and the bioinformatic handling of clones have on genotyping, we evaluate four RAD-seq data... Abstract
Cited 9 times since 2019 (1.9 per year) source: EuropePMC
PLoS computational biology, Volume 15, Issue 8, 28 4 2019, Pages e1006697 Tracking Pseudomonas aeruginosa transmissions due to environmental contamination after discharge in ICUs using mathematical models. Pham TM, Kretzschmar M, Bertrand X, Bootsma M, COMBACTE-MAGNET Consortium
Pseudomonas aeruginosa (P. aeruginosa) is an important cause of healthcare-associated infections, particularly in immunocompromised patients. Understanding how this multi-drug resistant pathogen is transmitted within intensive care units (ICUs) is crucial for devising and evaluating successful control strategies. While it is known that moist environments serve as natural reservoirs for P. aeruginosa, there is little quantitative evidence regarding the contribution of environmental contamination... Abstract
Cited 10 times since 2019 (2.1 per year) source: EuropePMC
BMJ open, Volume 9, Issue 7, 1 1 2019, Pages e029254 An observational study on survival rates of patients with out-of-hospital cardiac arrest in the Netherlands after improving the 'chain of survival'. de Visser M, Bosch J, Bootsma M, Cannegieter S, van Dijk A, Heringhaus C, de Nooij J, Terpstra N, Peschanski N, Burggraaf K
Objectives: To evaluate the impact of implemented procedures for out-of-hospital cardiac arrests (OHCAs) by determining patient outcome defined as the percentage return of spontaneous circulation at arrival at the emergency department, and 3-month and 1-year-survival rates. Design: Observational study. Setting: Primary emergency medical care consisting of Advanced Life Support is given by ambulance nurses and secondary care by hospitals within the mid-western part of the Netherlands covering 750... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 20, Issue 6, 1 1 2019, Pages 694-699 Left ventricular 2D speckle tracking echocardiography for detection of systolic dysfunction in genetic, dilated cardiomyopathies. van der Bijl P, Bootsma M, Hiemstra YL, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Genetic, dilated cardiomyopathy (DCM) can be caused by a large variety of mutations. Mutation carriers are often asymptomatic until DCM is well established, presenting with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies can only be applied if DCM can be detected early. Echocardiographic, left ventricular (LV) global longitudinal strain (GLS) is a promising tool for early diagnosis, i.e. before a decrease in LV ejection fraction (EF) has occurred. We, therefore,... Abstract
Cited 11 times since 2019 (2.2 per year) source: EuropePMC
The American journal of cardiology, Volume 124, Issue 4, 27 4 2019, Pages 604-612 Prevalence and Prognostic Implications of Right Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy. Hiemstra YL, Debonnaire P, Bootsma M, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Right ventricular (RV) dysfunction is a well-known prognostic factor in several cardiac diseases. However, the prevalence of RV dysfunction in hypertrophic cardiomyopathy (HC) is unclear and its prognostic value is unknown. This study aims at addressing these issues assessing RV function with speckle tracking echocardiography. In 267 HC patients (52 ± 15 years, 68% male), standard and advanced echocardiographic measurements of RV function were performed including RV 4-chamber longitudinal strain... Abstract
The Lancet. Infectious diseases, Volume 19, Issue 4, 4 1 2019, Pages 347-348 How fluoroquinolones poison the neighbourhood. van Werkhoven CH, Bootsma M, Bonten M
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
International journal of cardiology, Volume 280, 1 1 2018, Pages 19-28 Chest pain in the absence of obstructive coronary artery disease: A critical review of current concepts focusing on sex specificity, microcirculatory function, and clinical implications. Zijlstra LE, Bootsma M, Jukema JW, Schalij MJ, Vliegen HW, Bruschke AVG
Patients presenting with chest pain suggestive of coronary artery disease (CAD) who at coronary arteriography appear to be free of obstructive disease have presented a diagnostic and therapeutic challenge since the 1970's. Studies in female patient populations have suggested that this is predominantly a women's syndrome usually caused by microvascular endothelial dependent and independent dysfunction. A critical review of the literature focusing on studies including both women and men... Abstract
Cited 26 times since 2018 (4.5 per year) source: EuropePMC
Applied and environmental microbiology, Volume 84, Issue 14, 2 1 2018, Pages e00309-18 Human-Associated Lachnospiraceae Genetic Markers Improve Detection of Fecal Pollution Sources in Urban Waters. Feng S, Bootsma M, McLellan SL
The human microbiome contains many organisms that could potentially be used as indicators of human fecal pollution. Here we report the development of two novel human-associated genetic marker assays that target organisms within the family Lachnospiraceae Next-generation sequencing of the V6 region of the 16S rRNA gene from sewage and animal stool samples identified 40 human-associated marker candidates with a robust signal in sewage and low or no occurrence in samples from nonhuman hosts. Two we... Abstract
Cited 8 times since 2018 (1.4 per year) source: EuropePMC
The American journal of cardiology, Volume 122, Issue 4, 20 3 2018, Pages 656-662 Development of and Progression of Overt Heart Failure in Nonobstructive Hypertrophic Cardiomyopathy. Hiemstra YL, Debonnaire P, van Zwet EW, Bootsma M, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Only few studies aimed at identifying predictors of heart failure (HF) in hypertrophic cardiomyopathy (HC) patients. Furthermore, serial echocardiographic analyses are lacking in these patients and little is known about the natural progression of left ventricular (LV) abnormalities and their association with HF development. Aim of this study was to assess the prognostic value of LV global longitudinal strain (GLS) and other clinical and echocardiographic characteristics for the development of HF... Abstract
Cited 8 times since 2018 (1.4 per year) source: EuropePMC
Circulation, Volume 137, Issue 23, 1 1 2018, Pages 2514-2527 Risk Stratification of Genetic, Dilated Cardiomyopathies Associated With Neuromuscular Disorders: Role of Cardiac Imaging. van der Bijl P, Delgado V, Bootsma M, Bax JJ
The etiology of dilated cardiomyopathy (DCM) can be grouped as either genetic or nongenetic. More than 50 pathogenic genes have been described, with sarcomeric and lamin A/C mutations being the most common. Mutation carriers for genetic DCM are often asymptomatic until cardiac disease manifests with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies are promising but can only be applied and tested adequately if genetic DCM can be diagnosed at an early stage. Early diagnos... Abstract