Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
18 results
The Journal of invasive cardiology, Volume 35, Issue 11, 1 1 2023 Mitral valve transcatheter edge-to-edge repair with PASCAL Vs MitraClip: A aystematic teview and meta-analysis. Oliveri F, Al Amri I, Cabezas JM, Bingen B, Van Der Kley F, Arslan F, Scherptong R, Mazzarotto P, Bollati M, Pepe A, Tua L, Bongiorno A, Fasolino A, Gentile FR, Colombo D, Ghio S, Ferlini M, Munafo A
Background: Transcatheter edge-to-edge repair (TEER) using the MitraClip (Abbott Vascular) system has emerged as a standard treatment for patients with symptomatic severe secondary or inoperable primary mitral regurgitation (MR). The relatively recent approval of the PASCAL Transcatheter Valve Repair System (Edwards Lifesciences) has expanded the options of TEER devices. However, evidence comparing PASCAL with MitraClip systems is still limited. Methods: We conducted a systematic literature rese... Abstract
JACC. Cardiovascular interventions, Volume 16, Issue 22, 1 1 2023, Pages 2784-2785 Invasive Angiography in Elucidating Ambiguous Shunt Anatomy: Acquired Bicoronary-to-Right Atrium Fistula. Bingen BO, Al Amri I, Oliveri F, Cabezas JM
Cardiovascular revascularization medicine : including molecular interventions, Volume 61, 21 3 2023, Pages 16-23 Procedural and clinical impact of intravascular lithotripsy for the treatment of peri-stent calcification. van Oort MJH, Al Amri I, Bingen BO, Cordoba-Soriano JG, Karalis I, Sanz-Sanchez J, Oliveri F, van der Kley F, Jukema JW, Jurado-Roman A, Montero-Cabezas JM
Background: Use of intravascular lithotripsy (IVL) for treating peri-stent calcification is increasing. However, this indication remains 'off-label'. We aimed to investigate the efficacy and clinical outcomes of in-stent IVL. Methods: Patients from five European centers who underwent in-stent IVL were included between 2019 and 2023. Demographic, clinical, procedural and follow-up data were collected from electronic hospital records. Angiographic and intracoronary imaging (ICI) data wer... Abstract
JACC. Cardiovascular interventions, Volume 16, Issue 14, 21 3 2023, Pages 1813-1815 Retrograde Use of Intravascular Lithotripsy in Anterograde Uncrossable In-Stent Chronic Occlusion: "Retrotripsy Technique". Montero-Cabezas JM, Al Amri I, van Oort MJH, Bingen BO, Scherptong RWC, van der Kley F
JACC. Cardiovascular interventions, Volume 16, Issue 15, 16 3 2023, Pages 1950-1952 The Effect of Intravascular Lithotripsy on Cardiac Implantable Electronic Device Function. van Oort MJH, Bingen BO, Al Amri I, van der Kley F, Jukema JW, Montero-Cabezas JM
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 101, Issue 1, 16 3 2022, Pages 97-101 Bail out lithotripsy to treat delayed valve-in-valve TAVR-related coronary obstruction. Bingen BO, Al Amri I, Montero-Cabezas JM, van der Kley F
Coronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve-in-valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post-TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet. Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions, Volume 48, 29 5 2022, Pages 1-6 Efficacy and Safety of Intravascular Lithotripsy Versus Rotational Atherectomy in Balloon-Crossable Heavily Calcified Coronary Lesions. Mousa MAA, Bingen BO, Al Amri I, Mertens BJA, Taha S, Tohamy A, Youssef A, Jukema JW, Montero-Cabezas JM
Cited 1 times since 2022 (0.4 per year) source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions, Volume 40, 11 2 2022, Pages 189-194 Bailout Intravascular Lithotripsy for the Treatment of Acutely Underexpanded Stents in Heavily Calcified Coronary Lesions: A Case Series. Mousa MAA, Bingen BO, Amri IA, Digiacomo S, Karalis I, Jukema JW, Montero-Cabezas JM
Stent underexpansion is a common problem in heavily calcified coronary lesions treated with percutaneous coronary intervention, and has been associated with in-stent restenosis, stent thrombosis and, subsequently, poor clinical outcomes. Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherectomy or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion. How... Abstract
Cited 6 times since 2015 (0.7 per year) source: EuropePMC
Scientific reports, Volume 5, 21 3 2015, Pages 15187 Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation. Bingen BO, Askar SF, Neshati Z, Feola I, Panfilov AV, de Vries AA, Pijnappels DA
Electrical cardioversion (ECV), a mainstay in atrial fibrillation (AF) treatment, is unsuccessful in up to 10-20% of patients. An important aspect of the remodeling process caused by AF is the constitutive activition of the atrium-specific acetylcholine-dependent potassium current (IK,ACh → IK,ACh-c), which is associated with ECV failure. This study investigated the role of IK,ACh-c in ECV failure and setting the atrial defibrillation threshold (aDFT) in optically mapped neonatal rat cardiomyocy... Abstract
Cited 3 times since 2015 (0.3 per year) source: EuropePMC
Cardiovascular research, Volume 107, Issue 4, 3 1 2015, Pages 601-612 Forced fusion of human ventricular scar cells with cardiomyocytes suppresses arrhythmogenicity in a co-culture model. Engels MC, Askar SF, Jangsangthong W, Bingen BO, Feola I, Liu J, Majumder R, Versteegh MI, Braun J, Klautz RJ, Ypey DL, De Vries AA, Pijnappels DA
Aims: Fibrosis increases arrhythmogenicity in myocardial tissue by causing structural and functional disruptions in the cardiac syncytium. Forced fusion of fibroblastic cells with adjacent cardiomyocytes may theoretically resolve these disruptions. Therefore, the electrophysiological effects of such electrical and structural integration of fibroblastic cells into a cardiac syncytium were studied. Methods and results: Human ventricular scar cells (hVSCs) were transduced with lentiviral vectors en... Abstract
Cited 68 times since 2014 (7 per year) source: EuropePMC
Cardiovascular research, Volume 104, Issue 1, 31 5 2014, Pages 194-205 Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA
Aims: Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves reentrant electrical activation (e.g. spiral waves). Drug therapy for AF can have serious side effects including proarrhythmia, while electrical shock therapy is associated with discomfort and tissue damage. Hypothetically, forced expression and subsequent activation of light-gated cation channels in cardiomyocytes might deliver a depolarizing force sufficient for defibrillation, thereby circumventing the afo... Abstract
Cited 3 times since 2013 (0.3 per year) source: EuropePMC
Journal of African earth sciences (Oxford, England : 1994), Volume 86, 1 1 2013, Pages 65-106 Orogen styles in the East African Orogen: A review of the Neoproterozoic to Cambrian tectonic evolution. Fritz H, Abdelsalam M, Ali KA, Bingen B, Collins AS, Fowler AR, Ghebreab W, Hauzenberger CA, Johnson PR, Kusky TM, Macey P, Muhongo S, Stern RJ, Viola G
The East African Orogen, extending from southern Israel, Sinai and Jordan in the north to Mozambique and Madagascar in the south, is the world́s largest Neoproterozoic to Cambrian orogenic complex. It comprises a collage of individual oceanic domains and continental fragments between the Archean Sahara-Congo-Kalahari Cratons in the west and Neoproterozoic India in the east. Orogen consolidation was achieved during distinct phases of orogeny between ∼850 and 550 Ma. The northern part of the oroge... Abstract
Cited 25 times since 2013 (2.4 per year) source: EuropePMC
Circulation, Volume 128, Issue 25, 24 4 2013, Pages 2732-2744 Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans. Bingen BO, Neshati Z, Askar SF, Kazbanov IV, Ypey DL, Panfilov AV, Schalij MJ, de Vries AA, Pijnappels DA
Background: Atrial fibrillation is the most common cardiac arrhythmia. Ventricular proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium-specific Kir3.x channels, which generate a constitutively active current (I(K,ACh-c)) after atrial remodeling, might circumvent this problem. However, it is unknown whether and how I(K,ACh-c) contributes to atrial fibrillation induction, dynamics, and termination. Therefore, we investigated the effects of I(K,ACh-c) blockade... Abstract
Cardiovascular research, Volume 98, Issue 1, 7 1 2013, Pages 156-157 Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization: reply. Bingen BO, Askar SF, Schalij MJ, de Vries AA, Pijnappels DA
Cited 12 times since 2012 (1 per year) source: EuropePMC
Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 171-181 Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms. Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA
Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi... Abstract
Cited 17 times since 2012 (1.5 per year) source: EuropePMC
Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 161-170 Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization. Bingen BO, Askar SF, Schalij MJ, Kazbanov IV, Ypey DL, Panfilov AV, Pijnappels DA
Aims: Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability... Abstract
Cited 33 times since 2011 (2.7 per year) source: EuropePMC
Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA
Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract
Cited 26 times since 2011 (2 per year) source: EuropePMC
Cardiovascular research, Volume 90, Issue 2, 13 2 2011, Pages 295-304 Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA
Aims: Cardiac fibrosis is associated with increased incidence of cardiac arrhythmias, but the underlying proarrhythmic mechanisms remain incompletely understood and antiarrhythmic therapies are still suboptimal. This study tests the hypothesis that myofibroblast (MFB) proliferation leads to tachyarrhythmias by altering the excitability of cardiomyocytes (CMCs) and that inhibition of MFB proliferation would thus lower the incidence of such arrhythmias. Methods and results: Endogenous MFBs in neon... Abstract