Daniël A. Pijnappels, PhD

Daniël Pijnappels is associate professor and heading the Laboratory of Experimental Cardiology.

Daniël A. Pijnappels, PhD

He received his PhD with honors from Leiden University in 2009 and is specialized in cardiac electrophysiology, atrial & ventricular arrhythmias and synthetic biomedicine (i.e. the creation of novel biology for therapeutic purposes). One of the main aims of his group is to develop biological therapies for cardiac diseases, in particular cardiac arrhythmias, allowing the heart itself to detect and neutralize physiological disturbances. Here, cardiac optogenetics, i.e. forced expression of light-sensitive proteins and their subsequent activation by light to modulate cardiac function at unmatched spatiotemporal resolution, is one of the key means of investigation. Also, different models of cardiomyogenic differentiation are used to investigate how excitability and intercellular electrical communication is established and (dys)regulated in order to use these insights for synthetic biomedical purposes, i.e. generative medicine.

Since his appointment in early 2011, the lab has been reorganized and restyled, and the focus of research has shifted mainly onto cardiac arrhythmias and synthetic biomedicine. He has received personal funding from the ERC (2015 StG), ZonMw (2010 Veni, 2013 Vidi), the Dutch Heart Foundation, KNAW and Ammodo.

To address the aims as stated above, the lab houses an international team (>10 different nationalities since 2011) that combines various aspects of (synthetic) biology, mathematics, engineering and medicine. As a result, the research projects have both a strong multidisciplinary and translational focus. Also, different national and international collaborations have been established to maintain and further increase the multidisciplinary nature of these projects.

For more info about his work, please see the overview of scientific publications and summary of highlights.

Email: D.A.Pijnappels@lumc.nl 

For more info about how to contact Dr. Pijnappels, please visit the contact page.

Top-cited publications

118 times cited (±10/year) Source: Scopus

Stem cells (Dayton, Ohio), Volume 25, Issue 2, 21 September 2006, Pages 271-278 Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. van Tuyn J, Atsma DE, Winter EM, van der Velde-van Dijke I, Pijnappels DA, Bax NA, Knaän-Shanzer S, Gittenberger-de Groot AC, Poelmann RE, van der Laarse A, van der Wall EE, Schalij MJ, de Vries AA. Abstract

93 times cited (±7/year) Source: Scopus

Journal of the American College of Cardiology, Volume 46, Issue 10, 21 October 2005, Pages 1943-1952 Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ. Abstract

76 times cited (±7/year) Source: EuropePMC

Circulation research, Volume 103, Issue 2, 12 June 2008, Pages 167-176 Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures. Pijnappels DA, Schalij MJ, Ramkisoensing AA, van Tuyn J, de Vries AA, van der Laarse A, Ypey DL, Atsma DE. Abstract

Most recent publications

01 Dec 2018

Cardiovascular research, Volume 114, Issue 14, 01 December 2018, Pages 1848-1859 Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity. Liu J, Volkers L, Jangsangthong W, Bart CI, Engels MC, Zhou G, Schalij MJ, Ypey DL, Pijnappels DA, de Vries AAF. Abstract

01 Nov 2018

European heart journal, Volume 39, Issue 44, 01 November 2018, Pages 3915-3917 Biological defibrillation. Nyns ECA, de Vries AAF, Pijnappels DA. Abstract

27 Sep 2018

eLife, Volume 7, 27 September 2018 Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system. Majumder R, Feola I, Teplenin AS, de Vries AA, Panfilov AV, Pijnappels DA. Abstract