Daniël A. Pijnappels, PhD

Daniël Pijnappels is associate professor of Experimental Electrocardiology and Synthetic Biomedicine, and heading the Laboratory of Experimental Cardiology.

Daniël A. Pijnappels, PhD

He received his PhD with honors from Leiden University in 2009 and is specialized in cardiac electrophysiology, atrial & ventricular arrhythmias and synthetic biomedicine (which he defines as the creation of novel biology for therapeutic purposes). One of the main aims of his group is to develop biological therapies for cardiac diseases, in particular cardiac arrhythmias, allowing the heart itself to detect and neutralize physiological disturbances. Here, cardiac optogenetics, i.e. forced expression of light-sensitive proteins and their subsequent activation by light to modulate cardiac function at unmatched spatiotemporal resolution, is one of the key means of investigation. Also, different models of cardiomyogenic differentiation are used to investigate how excitability and intercellular electrical communication is established and (dys)regulated in order to use these insights for synthetic biomedical purposes, i.e. generative medicine.

Since his appointment in early 2011, the lab has been reorganized and restyled, and the focus of research has shifted mainly onto cardiac arrhythmias and synthetic biomedicine. He has received personal funding from the ERC (2015 StG), ZonMw (2010 Veni, 2013 Vidi), the Dutch Heart Foundation, KNAW and Ammodo.

To address the aims as stated above, the lab houses an international team (>15 different nationalities since 2011) that combines various aspects of (synthetic) biology, mathematics, engineering and medicine. As a result, the research projects have both a strong multidisciplinary and translational focus. Also, different national and international collaborations have been established to maintain and further increase the multidisciplinary nature of these projects.

For more info about his work, please see the overview of scientific publications and summary of highlights.

Email: D.A.Pijnappels@lumc.nl 

For more info about how to contact Dr. Pijnappels, please visit the contact page.

Top-cited publications

119 times cited (±9/year) Source: Scopus

Stem cells (Dayton, Ohio), Volume 25, Issue 2, 21 September 2006, Pages 271-278 Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. van Tuyn J, Atsma DE, Winter EM, van der Velde-van Dijke I, Pijnappels DA, Bax NA, Knaän-Shanzer S, Gittenberger-de Groot AC, Poelmann RE, van der Laarse A, van der Wall EE, Schalij MJ, de Vries AA. Abstract


93 times cited (±7/year) Source: Scopus

Journal of the American College of Cardiology, Volume 46, Issue 10, 21 October 2005, Pages 1943-1952 Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ. Abstract


78 times cited (±8/year) Source: Scopus

American journal of physiology. Heart and circulatory physiology, Volume 297, Issue 5, 25 September 2009, Pages H1606-16 Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension. Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani el H, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A. Abstract


Most recent publications

21 Mrt 2019

Nature communications, Volume 10, Issue 1, 21 March 2019, Pages 1307 DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation. Zhang D, Hu X, Li J, Liu J, Baks-Te Bulte L, Wiersma M, Malik NU, van Marion DMS, Tolouee M, Hoogstra-Berends F, Lanters EAH, van Roon AM, de Vries AAF, Pijnappels DA, de Groot NMS, Henning RH, Brundel BJJM. Abstract


01 Feb 2019

Science translational medicine, Volume 11, Issue 481, 01 February 2019 An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation. Nyns ECA, Poelma RH, Volkers L, Plomp JJ, Bart CI, Kip AM, van Brakel TJ, Zeppenfeld K, Schalij MJ, Zhang GQ, de Vries AAF, Pijnappels DA. Abstract


01 Dec 2018

Cardiovascular research, Volume 114, Issue 14, 01 December 2018, Pages 1848-1859 Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity. Liu J, Volkers L, Jangsangthong W, Bart CI, Engels MC, Zhou G, Schalij MJ, Ypey DL, Pijnappels DA, de Vries AAF. Abstract