Arti A. Ramkisoensing, MD, PhD

Arti Ramkisoensing is a cardiology resident and specialized in molecular & cellular cardiac biology.

Arti A. Ramkisoensing, MD, PhD

After finishing medical school and my masters in Biomedical Sciences, the decision to do a PhD at the laboratory of Experimental Cardiology was easily made. It gave me the opportunity to broaden my knowledge and skills in the field of cardiovascular stem cell biology without losing touch with the clinic. My PhD training mainly focused on unraveling environmental, molecular and genetic determinants of cardiac differentiation of human mesenchymal stem cells. Here you can find my full thesis.

Through these studies I came to realize that for cardiac regeneration by cell transplantation, not only the effects of the transplanted cells on host damage tissue are important, but that the effects of this host tissue on the guest cells (especially in terms of differentiation) is equally, or even more, important in steering the therapeutic potential. Currently, however, this aspect of cardiac regenerative medicine has been poorly investigated, due to a lack of dedicated research tools. One of my aims is to address this lack in knowledge, which might provide us with valuable insight into how to improve the therapeutic potential of cardiac regenerative medicine, despite all its remaining challenges. An overview of my scientific work can be found here.

After finishing my PhD training in late 2012, I entered the cardiology training program of the LUMC. In May 2014, I defended my thesis and obtained by PhD, while continuing my cardiology residency at the Rijnland Hospital in Leiderdorp. In returned to the LUMC in 2016. Here I will complete my training in early 2019 to become a cardiologist specialized in non-invasive imaging, while focusing on my pre-clinical research projects. With this combination I aim to serve the patient's best interest with today's clinical options, while contributing to the development and implementation of those of tomorrow.


Top-cited publications

87 times cited (±10/year) Source: Scopus

Circulation research, Volume 103, Issue 2, 12 June 2008, Pages 167-176 Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures. Pijnappels DA, Schalij MJ, Ramkisoensing AA, van Tuyn J, de Vries AA, van der Laarse A, Ypey DL, Atsma DE. Abstract

25 times cited (±4/year) Source: EurPubMed

PloS one, Volume 6, Issue 9, 09 September 2011, Pages e24164 Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AA, Scherjon S, Mummery CL, Schalij MJ, Atsma DE. Abstract

19 times cited (±3/year) Source: Scopus

Cardiovascular research, Volume 90, Issue 2, 13 January 2011, Pages 295-304 Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA. Abstract

Most recent publications

01 Nov 2014

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 11, 01 November 2014, Pages 491-492 Image-guided intramyocardial cell injection: putting a puzzle piece in the right place. Ramkisoensing AA, Atsma DE. Abstract

27 Feb 2014

Cardiovascular research, Volume 102, Issue 2, 27 February 2014, Pages 224-231 Interaction between myofibroblasts and stem cells in the fibrotic heart: balancing between deterioration and regeneration. Ramkisoensing AA, de Vries AA, Atsma DE, Schalij MJ, Pijnappels DA. Abstract

18 Feb 2013

Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 2, 18 February 2013, Pages 380-391 Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures. Askar SF, Ramkisoensing AA, Atsma DE, Schalij MJ, de Vries AA, Pijnappels DA. Abstract