Laboratory for Respiratory Cell Biology and

The Laboratory for Respiratory Cell Biology and Immunology (head: prof. dr. Pieter S. Hiemstra) is located on the D3-floor of building 1 of the LUMC, very close to the other sections of the department. On the D3 floor, also the laboratory of the Department of Rheumatology and Nephrology are located that share the focus on chronic inflammation with the Department of Pulmonology. This clustering of research on chronic inflammation is also evident from the shared journal club of the three laboratories. Various relevant cell culture models are operational, including state-of-the-art air-liquid interface 3D culture models of primary human airway epithelial cells. In addition, a dedicated immunohistochemistry and imaging unit is present for analysis of lung tissue. Mouse models for allergic airways inflammation, COPD and atherosclerosis (collaboration with the Department of Endocrinology) are used to answer questions where interactions between various organs and systems take center stage.

 Video images from the Laboratory of Respiratory Cell Biology and Immunology.

In this video a demonstration is given of the whole cigarette smoke exposure model, which is used by our research group to explore the effect of cigarette smoke on airway epithelial cells.